Spyre Therapeutics (SYRE) Return on Invested Capital (2022 - 2025)
Spyre Therapeutics posted quarterly Return on Invested Capital of 0.0% for Q4 2025, little changed year-on-year from 0.0% in Q4 2024, and up 20.03% on a QoQ basis from 0.0% in Q3 2025.
Spyre Therapeutics (SYRE) has 4 years of Return on Invested Capital data on file, last reported at 0.0% in Q4 2025.
- For the quarter ending Q4 2025, Return on Invested Capital changed 0.0% year-over-year to 0.0%; the trailing twelve-month figure through Dec 2025 stood at 0.0% (changed 0.0% YoY), and the FY2025 full-year result was 0.0%, changed 0.0% from the prior year.
- Return on Invested Capital for Q4 2025 stood at 0.0%, up from 0.0% in the prior quarter.
- Across five years, Return on Invested Capital topped out at 0.46% in Q2 2023 and bottomed at 0.02% in Q1 2023.
- The 4-year median for Return on Invested Capital is 0.0% (2024), against an average of 0.03%.
- The widest annual swing landed in 2023, when Return on Invested Capital surged 47 bps; it then sank 47 bps in 2024.
- A 4-year view of Return on Invested Capital shows it stood at 0.01% in 2022, then soared by 743 bps to 0.09% in 2023, then slumped by 105 bps to 0.0% in 2024, then gained by 25 bps to 0.0% in 2025.
- The last three Return on Invested Capital figures came in at 0.0% (Q4 2025), 0.0% (Q3 2025), and 0.0% (Q2 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROIC (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | - |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | - |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | -0.01% |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 0.00% |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | -0.01% |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 0.00% |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 0.01% |
| 10 | Spyre Therapeutics | 5.55 Bn | 5.55 Bn | - | - |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 0.00% |
| Sep 30, 2025 | 0.00% |
| Jun 30, 2025 | 0.00% |
| Mar 31, 2025 | 0.00% |
| Dec 31, 2024 | 0.00% |
| Sep 30, 2024 | -0.01% |
| Jun 30, 2024 | -0.01% |
| Mar 31, 2024 | -0.02% |
| Dec 31, 2023 | 0.09% |
| Sep 30, 2023 | 0.02% |
| Jun 30, 2023 | 0.46% |
| Mar 31, 2023 | -0.02% |
| Dec 31, 2022 | -0.01% |
| Sep 30, 2022 | -0.01% |
| Jun 30, 2022 | -0.01% |
| Mar 31, 2022 | -0.01% |