Spyre Therapeutics (SYRE) Operating Expenses (2015 - 2026)

Spyre Therapeutics (SYRE) has 12 years of Operating Expenses data on file, last reported at $45.6 million in Q1 2026.

• For the quarter ending Q1 2026, Operating Expenses fell 14.8% year-over-year to $45.6 million; the trailing twelve-month figure through Mar 2026 stood at $201.6 million (down 5.94% YoY), and the FY2025 full-year result was $209.6 million, changed 0.48% from the prior year.
• Operating Expenses for Q1 2026 stood at $45.6 million, down from $57.2 million in the prior quarter.
• Across five years, Operating Expenses topped out at $159.9 million in Q2 2023 and bottomed at $18.3 million in Q3 2023.
• The 5-year median for Operating Expenses is $45.6 million (2026), against an average of $46.7 million.
• The widest annual swing landed in 2023, when Operating Expenses jumped 593.92%; it then slumped 72.4% in 2024.
• A 5-year view of Operating Expenses shows it stood at $19.3 million in 2022, then soared by 137.53% to $45.9 million in 2023, then jumped by 33.41% to $61.3 million in 2024, then decreased by 6.66% to $57.2 million in 2025, then fell by 20.17% to $45.6 million in 2026.
• The last three Operating Expenses figures came in at $45.6 million (Q1 2026), $57.2 million (Q4 2025), and $56.9 million (Q3 2025), per Business Quant data.

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