Spyre Therapeutics (SYRE) EPS (Basic) (2015 - 2026)
Spyre Therapeutics posted quarterly EPS (Basic) of -$0.74 for Q1 2026, up 96.91% year-on-year from -$0.38 in Q1 2025, and up 99.05% on a QoQ basis from -$77.78 in Q4 2025.
Spyre Therapeutics (SYRE) has 12 years of EPS (Basic) data on file, last reported at -$0.74 in Q1 2026.
- For the quarter ending Q1 2026, EPS (Basic) rose 96.91% year-over-year to -$0.74; the trailing twelve-month figure through Mar 2026 stood at -$104.11 (down 14.92% YoY), and the FY2025 full-year result was -$79.02, down 2384.91% from the prior year.
- EPS (Basic) for Q1 2026 stood at -$0.74, up from -$77.78 in the prior quarter.
- Across five years, EPS (Basic) topped out at $40.14 in Q2 2023 and bottomed at -$77.78 in Q4 2025.
- The 5-year median for EPS (Basic) is -$4.89 (2023), against an average of -$13.3.
- The widest annual swing landed in 2023, when EPS (Basic) soared 14966.67%; it then slumped 9745.57% in 2025.
- A 5-year view of EPS (Basic) shows it stood at -$4.69 in 2022, then slumped by 505.76% to -$28.41 in 2023, then jumped by 97.22% to -$0.79 in 2024, then plunged by 9745.57% to -$77.78 in 2025, then surged by 99.05% to -$0.74 in 2026.
- The last three EPS (Basic) figures came in at -$0.74 (Q1 2026), -$77.78 (Q4 2025), and -$5.97 (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EPS (Basic) (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | 3.06 |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | 0.00 |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | 0.00 |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 4.06 |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | 0.00 |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 6.99 |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 1.55 |
| 10 | Spyre Therapeutics | 5.55 Bn | 5.55 Bn | - | -0.74 |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -0.74 |
| Dec 31, 2025 | -77.78 |
| Sep 30, 2025 | -5.97 |
| Jun 30, 2025 | -19.62 |
| Mar 31, 2025 | -23.95 |
| Dec 31, 2024 | -0.79 |
| Sep 30, 2024 | -42.24 |
| Jun 30, 2024 | -23.61 |
| Mar 31, 2024 | -28.93 |
| Dec 31, 2023 | -28.41 |
| Sep 30, 2023 | 0.86 |
| Jun 30, 2023 | 40.14 |
| Mar 31, 2023 | -4.89 |
| Dec 31, 2022 | -4.69 |
| Sep 30, 2022 | -4.84 |
| Jun 30, 2022 | -0.27 |
| Mar 31, 2022 | -0.37 |
| Dec 31, 2021 | 0.69 |
| Sep 30, 2021 | -0.31 |
| Jun 30, 2021 | -0.10 |
| Mar 31, 2021 | -0.28 |
| Dec 31, 2020 | -0.35 |
| Sep 30, 2020 | -0.29 |
| Jun 30, 2020 | -0.40 |
| Mar 31, 2020 | -0.57 |
| Dec 31, 2019 | -0.65 |
| Sep 30, 2019 | -0.66 |
| Jun 30, 2019 | -0.55 |
| Mar 31, 2019 | -0.59 |
| Dec 31, 2018 | -0.62 |
| Sep 30, 2018 | -0.54 |
| Jun 30, 2018 | -0.46 |
| Mar 31, 2018 | -0.49 |
| Dec 31, 2017 | -0.39 |
| Sep 30, 2017 | -0.48 |
| Jun 30, 2017 | -0.47 |
| Mar 31, 2017 | -0.47 |
| Dec 31, 2016 | -0.41 |
| Sep 30, 2016 | -0.47 |
| Jun 30, 2016 | -0.46 |
| Mar 31, 2016 | -7.10 |
| Dec 31, 2015 | -6.36 |
| Sep 30, 2015 | -5.57 |
| Jun 30, 2015 | -2.44 |
| Mar 31, 2015 | -4.71 |