Spyre Therapeutics (SYRE) Consolidated Net Income (2015 - 2026)

Spyre Therapeutics (SYRE) reported Consolidated Net Income of -$69.0 million for Q1 2026, down 54.12% on a YoY basis from -$150.4 million in Q1 2025, and down 10.36% quarter-over-quarter from -$62.5 million in Q4 2025.

Spyre Therapeutics (SYRE) Consolidated Net Income (2015 - 2026) Analysis & Trends

Spyre Therapeutics has reported Consolidated Net Income for 12 years, with the latest figure at -$69.0 million in Q1 2026.

  • For the quarter ending Q1 2026, Consolidated Net Income fell 54.12% year-over-year to -$69.0 million; the trailing twelve-month figure through Mar 2026 stood at -$179.4 million (up 14.12% YoY), and the FY2025 full-year result was -$155.2 million, up 25.39% from the prior year.
  • Consolidated Net Income for Q1 2026 stood at -$69.0 million, down from -$62.5 million in the prior quarter.
  • The five-year high for Consolidated Net Income was -$11.2 million in Q3 2025, with the low at -$217.1 million in Q2 2023.
  • Historically, Consolidated Net Income has averaged -$50.3 million across 5 years, with a median of -$40.1 million in 2023.
  • Annual changes were most pronounced in 2023 — Consolidated Net Income sank 872.45% — and 2025, when it surged 83.8%.
  • Spyre Therapeutics' Consolidated Net Income stood at -$18.8 million in 2022, then slumped by 235.67% to -$63.2 million in 2023, then advanced by 10.9% to -$56.3 million in 2024, then decreased by 11.07% to -$62.5 million in 2025, then dropped by 10.36% to -$69.0 million in 2026.
  • The last three Consolidated Net Income figures came in at -$69.0 million (Q1 2026), -$62.5 million (Q4 2025), and -$11.2 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Consol Net Inc. (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -26.94 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -2.97 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 30.80 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -3.40 Mn
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -14.46 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -1.50 Mn
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.03 Bn
9 Abivax 91.96 Bn 91.96 Bn - -56.48 Mn
10 Spyre Therapeutics 6.95 Bn 6.95 Bn - -69.01 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -69.01 Mn
Dec 31, 2025 -62.53 Mn
Sep 30, 2025 -11.18 Mn
Jun 30, 2025 -36.72 Mn
Mar 31, 2025 -44.77 Mn
Dec 31, 2024 -56.30 Mn
Sep 30, 2024 -69.03 Mn
Jun 30, 2024 -38.84 Mn
Mar 31, 2024 -43.86 Mn
Dec 31, 2023 -63.18 Mn
Sep 30, 2023 -40.11 Mn
Jun 30, 2023 -217.08 Mn
Mar 31, 2023 -18.42 Mn
Dec 31, 2022 -18.82 Mn
Sep 30, 2022 -18.23 Mn
Jun 30, 2022 -22.32 Mn
Mar 31, 2022 -24.44 Mn
Dec 31, 2021 -20.45 Mn
Sep 30, 2021 -20.31 Mn
Jun 30, 2021 -6.83 Mn