Spyre Therapeutics SYRE
NASDAQ SYRE
$88.78 +1.53 (+1.75%)
As of: Sep 4, 2026 · 3:25 PM EDT

Spyre Therapeutics (SYRE) Consolidated Net Income (2015 - 2026)

Spyre Therapeutics' (SYRE) quarterly Consolidated Net Income came in at -$69.0 million in Q1 2026, down 54.12% YoY from -$150.4 million in Q1 2025, and down 10.36% on a QoQ basis from -$62.5 million in Q4 2025.

Analysis

Spyre Therapeutics (SYRE) Consolidated Net Income (2015 - 2026) Analysis & Trends

Spyre Therapeutics (SYRE) has 12 years of Consolidated Net Income data on file, last reported at -$69.0 million in Q1 2026.

  • Quarterly Consolidated Net Income fell 54.12% year-over-year to -$69.0 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was -$179.4 million (up 14.12% YoY) and the FY2025 annual result came in at -$155.2 million, up 25.39% from the prior year.
  • Consolidated Net Income eased to -$69.0 million in Q1 2026, from -$62.5 million in the prior quarter.
  • In the past five years, Consolidated Net Income ranged from a high of -$11.2 million in Q3 2025 to a low of -$217.1 million in Q2 2023.
  • A 5-year average of -$50.3 million and a median of -$40.1 million in 2023 frame the typical range for Consolidated Net Income.
  • Annual changes were most pronounced in 2023 — Consolidated Net Income sank 872.45% — and 2025, when it surged 83.8%.
  • Tracing SYRE's Consolidated Net Income over 5 years: stood at -$18.8 million in 2022, then slumped by 235.67% to -$63.2 million in 2023, then advanced by 10.9% to -$56.3 million in 2024, then decreased by 11.07% to -$62.5 million in 2025, then dropped by 10.36% to -$69.0 million in 2026.
  • The last three Consolidated Net Income figures came in at -$69.0 million (Q1 2026), -$62.5 million (Q4 2025), and -$11.2 million (Q3 2025), per Business Quant data.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Consol Net Inc. (Qtr)
1 Vertex Pharmaceuticals 138.37 Bn 130.52 Bn 2.84 Bn 1.10 Bn
2 Regeneron Pharmaceuticals 85.18 Bn 77.18 Bn 3.93 Bn 1.30 Bn
3 Argenx Se 63.33 Bn 58.15 Bn 1.37 Bn 601.00 Mn
4 Moderna 57.92 Bn 52.78 Bn 52.00 Mn -782.00 Mn
5 Revolution Medicines 43.98 Bn 43.98 Bn - -644.37 Mn
6 BeOne Medicines 40.04 Bn 34.94 Bn 1.53 Bn 237.01 Mn
7 Alnylam Pharmaceuticals 35.48 Bn 32.17 Bn 992.69 Mn 164.49 Mn
8 Royalty Pharma 28.42 Bn 27.58 Bn - 81.49 Mn
9 Insmed 27.38 Bn 26.22 Bn 358.27 Mn -13.27 Mn
10 Spyre Therapeutics 7.52 Bn 7.52 Bn - -36.20 Mn
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 -36.20 Mn
Mar 31, 2026 -69.01 Mn
Dec 31, 2025 -62.53 Mn
Sep 30, 2025 -11.18 Mn
Jun 30, 2025 -36.72 Mn
Mar 31, 2025 -44.77 Mn
Dec 31, 2024 -56.30 Mn
Sep 30, 2024 -69.03 Mn
Jun 30, 2024 -38.84 Mn
Mar 31, 2024 -43.86 Mn
Dec 31, 2023 -63.18 Mn
Sep 30, 2023 -40.11 Mn
Jun 30, 2023 -217.08 Mn
Mar 31, 2023 -18.42 Mn
Dec 31, 2022 -18.82 Mn
Sep 30, 2022 -18.23 Mn
Jun 30, 2022 -22.32 Mn
Mar 31, 2022 -24.44 Mn
Dec 31, 2021 -20.45 Mn
Sep 30, 2021 -20.31 Mn