Spyre Therapeutics (SYRE) Shares Issued (2017 - 2026)

Spyre Therapeutics posted quarterly Shares Issued of $2.7 million for Q1 2026, up 1127.52% year-on-year from $218000.0 in Q1 2025, and down 19.06% on a QoQ basis from $3.3 million in Q4 2025.

Spyre Therapeutics (SYRE) has 10 years of Shares Issued data on file, last reported at $2.7 million in Q1 2026.

  • For the quarter ending Q1 2026, Shares Issued rose 1127.52% year-over-year to $2.7 million; the trailing twelve-month figure through Mar 2026 stood at $5.8 million (up 103.57% YoY), and the FY2025 full-year result was $3.3 million, down 55.98% from the prior year.
  • Shares Issued for Q1 2026 stood at $2.7 million, down from $3.3 million in the prior quarter.
  • Across five years, Shares Issued topped out at $169.2 million in Q1 2024 and bottomed at -$164.3 million in Q2 2024.
  • The 5-year median for Shares Issued is $201000.0 (2022), against an average of $1.0 million.
  • Peak annual rise in Shares Issued reached 939927.78% in 2024, while the deepest fall reached 57312.41% in 2024.
  • A 5-year view of Shares Issued shows it stood at $38000.0 in 2022, then soared by 642.11% to $282000.0 in 2023, then plunged by 57312.41% to -$161.3 million in 2024, then soared by 102.05% to $3.3 million in 2025, then decreased by 19.06% to $2.7 million in 2026.
  • The last three Shares Issued figures came in at $2.7 million (Q1 2026), $3.3 million (Q4 2025), and -$1.1 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Shares Issued (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - 5.40 Mn
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn -
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - -
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 27.00 Mn
7 Evaxion A 62.56 Bn 62.54 Bn - -
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 163.10 Mn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 13.16 Mn
10 Spyre Therapeutics 5.55 Bn 5.55 Bn - 2.68 Mn

Historic Data

Download Data 🔒
DateValue
Mar 31, 2026 2.68 Mn
Mar 31, 2026 2.68 Mn
Dec 31, 2025 3.31 Mn
Dec 31, 2025 3.31 Mn
Sep 30, 2025 -1.07 Mn
Sep 30, 2025 -1.07 Mn
Jun 30, 2025 848,000.00
Jun 30, 2025 848,000.00
Mar 31, 2025 218,000.00
Mar 31, 2025 218,000.00
Dec 31, 2024 -161.34 Mn
Dec 31, 2024 -161.34 Mn
Sep 30, 2024 163.97 Mn
Sep 30, 2024 163.97 Mn
Jun 30, 2024 -164.32 Mn
Jun 30, 2024 -164.32 Mn
Mar 31, 2024 169.21 Mn
Mar 31, 2024 169.21 Mn
Dec 31, 2023 282,000.00
Dec 31, 2023 282,000.00
Sep 30, 2023 105,000.00
Sep 30, 2023 105,000.00
Mar 31, 2023 18,000.00
Mar 31, 2023 18,000.00
Sep 30, 2022 38,000.00
Sep 30, 2022 38,000.00
Mar 31, 2022 184,000.00
Mar 31, 2022 184,000.00
Dec 31, 2021 -1.65 Mn
Dec 31, 2021 -1.65 Mn
Sep 30, 2021 1.25 Mn
Sep 30, 2021 1.25 Mn
Jun 30, 2021 36,000.00
Jun 30, 2021 36,000.00
Mar 31, 2021 367,000.00
Mar 31, 2021 367,000.00
Dec 31, 2020 24.60 Mn
Dec 31, 2020 24.60 Mn
Sep 30, 2020 411,000.00
Sep 30, 2020 411,000.00
Jun 30, 2020 -128.67 Mn
Jun 30, 2020 -128.67 Mn
Mar 31, 2020 289,000.00
Mar 31, 2020 289,000.00
Dec 31, 2019 624,000.00
Dec 31, 2019 624,000.00
Sep 30, 2019 376,000.00
Sep 30, 2019 376,000.00
Jun 30, 2019 51,000.00
Jun 30, 2019 51,000.00
Mar 31, 2019 399,000.00
Mar 31, 2019 399,000.00
Dec 31, 2018 867,000.00
Dec 31, 2018 867,000.00
Sep 30, 2018 1.09 Mn
Sep 30, 2018 1.09 Mn
Jun 30, 2018 373,000.00
Jun 30, 2018 373,000.00
Mar 31, 2018 688,000.00
Mar 31, 2018 688,000.00
Dec 31, 2017 684,000.00
Dec 31, 2017 684,000.00
Sep 30, 2017 53,000.00
Sep 30, 2017 53,000.00
Mar 31, 2017 96,000.00
Mar 31, 2017 96,000.00