Spyre Therapeutics (SYRE) Cash from Financing Activities (2015 - 2026)

Spyre Therapeutics posted quarterly Cash from Financing Activities of $12.3 million for Q1 2026, up 9704.0% year-on-year from $125000.0 in Q1 2025, and down 96.08% on a QoQ basis from $312.8 million in Q4 2025.

Spyre Therapeutics (SYRE) has 12 years of Cash from Financing Activities data on file, last reported at $12.3 million in Q1 2026.

  • For the quarter ending Q1 2026, Cash from Financing Activities rose 9704.0% year-over-year to $12.3 million; the trailing twelve-month figure through Mar 2026 stood at $321.2 million (up 34.45% YoY), and the FY2025 full-year result was $309.0 million, down 24.79% from the prior year.
  • Cash from Financing Activities for Q1 2026 stood at $12.3 million, down from $312.8 million in the prior quarter.
  • Across five years, Cash from Financing Activities topped out at $312.8 million in Q4 2025 and bottomed at -$12.5 million in Q3 2023.
  • The 5-year median for Cash from Financing Activities is $731000.0 (2025), against an average of $66.8 million.
  • Peak annual rise in Cash from Financing Activities reached 2045175.0% in 2023, while the deepest fall reached 9539.23% in 2023.
  • A 5-year view of Cash from Financing Activities shows it stood at -$8000.0 in 2022, then jumped by 2045175.0% to $163.6 million in 2023, then soared by 37.89% to $225.6 million in 2024, then surged by 38.66% to $312.8 million in 2025, then slumped by 96.08% to $12.3 million in 2026.
  • The last three Cash from Financing Activities figures came in at $12.3 million (Q1 2026), $312.8 million (Q4 2025), and -$4.6 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Cash from Financing Activities (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - 7.00 Mn
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn -600,000.00
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - 53,000.00
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn -538.80 Mn
7 Evaxion A 62.56 Bn 62.54 Bn - -
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn -802.20 Mn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 15.71 Mn
10 Spyre Therapeutics 5.55 Bn 5.55 Bn - 12.26 Mn

Historic Data

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DateValue
Mar 31, 2026 12.26 Mn
Mar 31, 2026 12.26 Mn
Dec 31, 2025 312.81 Mn
Dec 31, 2025 312.81 Mn
Sep 30, 2025 -4.64 Mn
Sep 30, 2025 -4.64 Mn
Jun 30, 2025 731,000.00
Jun 30, 2025 731,000.00
Mar 31, 2025 125,000.00
Mar 31, 2025 125,000.00
Dec 31, 2024 225.60 Mn
Dec 31, 2024 225.60 Mn
Sep 30, 2024 12.78 Mn
Sep 30, 2024 12.78 Mn
Jun 30, 2024 360,000.00
Jun 30, 2024 360,000.00
Mar 31, 2024 172.17 Mn
Mar 31, 2024 172.17 Mn
Dec 31, 2023 163.61 Mn
Dec 31, 2023 163.61 Mn
Sep 30, 2023 -12.53 Mn
Sep 30, 2023 -12.53 Mn
Jun 30, 2023 209.99 Mn
Jun 30, 2023 209.99 Mn
Mar 31, 2023 10,000.00
Mar 31, 2023 10,000.00
Dec 31, 2022 -8,000.00
Dec 31, 2022 -8,000.00
Sep 30, 2022 -130,000.00
Sep 30, 2022 -130,000.00
Jun 30, 2022 42.80 Mn
Jun 30, 2022 42.80 Mn
Mar 31, 2022 12,000.00
Mar 31, 2022 12,000.00
Dec 31, 2021 80,000.00
Dec 31, 2021 80,000.00
Sep 30, 2021 1.14 Mn
Sep 30, 2021 1.14 Mn
Jun 30, 2021 -192,000.00
Jun 30, 2021 -192,000.00
Mar 31, 2021 362,000.00
Mar 31, 2021 362,000.00
Dec 31, 2020 24.68 Mn
Dec 31, 2020 24.68 Mn
Sep 30, 2020 258,000.00
Sep 30, 2020 258,000.00
Jun 30, 2020 129.29 Mn
Jun 30, 2020 129.29 Mn
Mar 31, 2020 282,000.00
Mar 31, 2020 282,000.00
Dec 31, 2019 676,000.00
Dec 31, 2019 676,000.00
Sep 30, 2019 311,000.00
Sep 30, 2019 311,000.00
Jun 30, 2019 -319,000.00
Jun 30, 2019 -319,000.00
Mar 31, 2019 65.06 Mn
Mar 31, 2019 65.06 Mn
Dec 31, 2018 17.26 Mn
Dec 31, 2018 17.26 Mn
Sep 30, 2018 1.06 Mn
Sep 30, 2018 1.06 Mn
Jun 30, 2018 38.06 Mn
Jun 30, 2018 38.06 Mn
Mar 31, 2018 688,000.00
Mar 31, 2018 688,000.00
Dec 31, 2017 684,000.00
Dec 31, 2017 684,000.00
Sep 30, 2017 -118,000.00
Sep 30, 2017 -118,000.00
Jun 30, 2017 11.55 Mn
Jun 30, 2017 11.55 Mn
Mar 31, 2017 96,000.00
Mar 31, 2017 96,000.00
Sep 30, 2016 76,000.00
Sep 30, 2016 76,000.00
Jun 30, 2016 49.39 Mn
Jun 30, 2016 49.39 Mn
Mar 31, 2016 -98,000.00
Mar 31, 2016 -98,000.00
Dec 31, 2015 -203,000.00
Dec 31, 2015 -203,000.00
Sep 30, 2015 -970,000.00
Sep 30, 2015 -970,000.00
Jun 30, 2015 -831,000.00
Jun 30, 2015 -831,000.00
Mar 31, 2015 43.68 Mn
Mar 31, 2015 43.68 Mn