Spyre Therapeutics (SYRE) Change in Cash (2015 - 2026)
Spyre Therapeutics' Change in Cash came in at $64.82 million for Q2 2026, up 95.4% from $33.17 million a year earlier and up 465.4% from the prior quarter.
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Analysis
Spyre Therapeutics (SYRE) Change in Cash (2015 - 2026) Analysis & Trends
Over the trailing twelve months to Jun 30, 2026, Spyre Therapeutics reported Change in Cash of $80.35 million, up 122.0% year-over-year; for FY2025, it came in at -$3.7 million.
- Going back by year, Change in Cash was -$99.79 million in FY2024, $152.8 million in FY2023 (+686.2%), $19.44 million in FY2022 and -$74.96 million in FY2021.
- The Q2 2026 figure represents the highest quarterly Change in Cash since Q4 2023.
- Business Quant data shows SYRE's Change in Cash at $11.46 million (Q1 2026), $20.82 million (Q4 2025) and -$16.76 million (Q3 2025) in the three quarters before Q2 2026.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Change in Cash (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,076.25 Bn | 1,044.84 Bn | 19.71 Bn | 3.67 Bn |
| 2 | Johnson & Johnson | 617.18 Bn | 535.70 Bn | 17.26 Bn | -1.27 Bn |
| 3 | AbbVie | 464.58 Bn | 437.73 Bn | 12.70 Bn | -2.82 Bn |
| 4 | Merck | 356.04 Bn | 310.47 Bn | 12.21 Bn | 1.49 Bn |
| 5 | Novartis Ag | 269.07 Bn | 224.94 Bn | 11.24 Bn | 739.00 Mn |
| 6 | Astrazeneca | 243.21 Bn | 216.77 Bn | 12.86 Bn | -2.64 Bn |
| 7 | Amgen | 217.88 Bn | 173.28 Bn | 7.24 Bn | 1.95 Bn |
| 8 | Gilead Sciences | 179.62 Bn | 153.74 Bn | 6.22 Bn | -4.45 Bn |
| 9 | Pfizer | 158.45 Bn | 105.40 Bn | 10.94 Bn | -727.00 Mn |
| 10 | Spyre Therapeutics | 8.21 Bn | 8.21 Bn | - | 64.82 Mn |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 64.82 Mn |
| Mar 31, 2026 | 11.46 Mn |
| Dec 31, 2025 | 20.82 Mn |
| Sep 30, 2025 | -16.76 Mn |
| Jun 30, 2025 | 33.17 Mn |
| Mar 31, 2025 | -40.93 Mn |
| Dec 31, 2024 | 17.84 Mn |
| Sep 30, 2024 | 26.12 Mn |
| Jun 30, 2024 | -182.41 Mn |
| Mar 31, 2024 | 38.66 Mn |
| Dec 31, 2023 | 97.32 Mn |
| Sep 30, 2023 | -144.78 Mn |
| Jun 30, 2023 | 200.12 Mn |
| Mar 31, 2023 | 137,000.00 |
| Dec 31, 2022 | -4.10 Mn |
| Sep 30, 2022 | 1.24 Mn |
| Jun 30, 2022 | 22.81 Mn |
| Mar 31, 2022 | -515,000.00 |
| Dec 31, 2021 | -9.52 Mn |
| Sep 30, 2021 | -10.11 Mn |
API Access
Spyre Therapeutics Change in Cash API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=change-in-cash&ticker=SYRE&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "change-in-cash", "ticker": "SYRE", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=change-in-cash&ticker=SYRE&period=max&api_key=YOUR_API_KEY");
const data = await res.json();