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Spyre Therapeutics (SYRE) Change in Cash (2016 - 2025)

Spyre Therapeutics (SYRE) has disclosed Change in Cash for 11 consecutive years, with $20.8 million as the latest value for Q4 2025.

  • For the quarter ending Q4 2025, Change in Cash rose 16.71% year-over-year to $20.8 million, compared with a TTM value of -$3.7 million through Dec 2025, up 96.29%, and an annual FY2025 reading of -$3.7 million, up 96.29% over the prior year.
  • Change in Cash was $20.8 million for Q4 2025 at Spyre Therapeutics, up from -$16.8 million in the prior quarter.
  • Across five years, Change in Cash topped out at $200.1 million in Q2 2023 and bottomed at -$182.4 million in Q2 2024.
  • Average Change in Cash over 5 years is -$310800.0, with a median of -$189000.0 recorded in 2022.
  • The sharpest move saw Change in Cash tumbled 11737.94% in 2023, then surged 28116.06% in 2024.
  • Year by year, Change in Cash stood at -$9.5 million in 2021, then skyrocketed by 56.92% to -$4.1 million in 2022, then surged by 2472.4% to $97.3 million in 2023, then plummeted by 81.66% to $17.8 million in 2024, then grew by 16.71% to $20.8 million in 2025.
  • Business Quant data shows Change in Cash for SYRE at $20.8 million in Q4 2025, -$16.8 million in Q3 2025, and $33.2 million in Q2 2025.