Spyre Therapeutics (SYRE) Market Capitalization (2016 - 2026)
Spyre Therapeutics' Market Capitalization was $7.82 billion in Q2 2026, up 765.1% from $903.78 million a year earlier and up 96.6% from the prior quarter.
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Analysis
Spyre Therapeutics (SYRE) Market Capitalization (2016 - 2026) Analysis & Trends
For FY2025, Market Capitalization at Spyre Therapeutics came in at $2.11 billion, up 90.9% from FY2024.
- Market Capitalization has now increased for three consecutive years, with a five-year compound annual growth rate of 41.1% (FY2020 to FY2025).
- In earlier years, Market Capitalization was $1.11 billion in FY2024 (+599.8%), $157.96 million in FY2023 (+316.5%), $37.93 million in FY2022 (-87.9%) and $312.29 million in FY2021 (-17.3%).
- The Q2 2026 figure marks the highest quarterly Market Capitalization in data going back to Q2 2016.
- Compared with a year earlier, Market Capitalization has increased for three straight quarters, with growth averaging 239.6% over the last seven quarters.
- The best year-over-year quarter for Market Capitalization over five years was Q2 2026 (growth of 765.1%); the worst was Q2 2022 (a decline of 90.9%).
- Per Business Quant data, SYRE's Market Capitalization in the three quarters before Q2 2026 was $3.98 billion (Q1 2026), $2.11 billion (Q4 2025) and $1.01 billion (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) |
|---|---|---|---|---|
| 1 | Johnson & Johnson | 638.12 Bn | 556.64 Bn | 17.26 Bn |
| 2 | AbbVie | 462.60 Bn | 435.75 Bn | 12.70 Bn |
| 3 | Merck | 358.70 Bn | 313.13 Bn | 12.21 Bn |
| 4 | Novartis Ag | 272.16 Bn | 228.03 Bn | 11.24 Bn |
| 5 | Astrazeneca | 250.36 Bn | 223.92 Bn | 12.86 Bn |
| 6 | Amgen | 227.87 Bn | 183.27 Bn | 7.24 Bn |
| 7 | Gilead Sciences | 184.97 Bn | 159.08 Bn | 6.22 Bn |
| 8 | Pfizer | 162.61 Bn | 109.56 Bn | 10.94 Bn |
| 9 | Vertex Pharmaceuticals | 132.45 Bn | 104.46 Bn | 2.84 Bn |
| 10 | Spyre Therapeutics | 7.84 Bn | 7.84 Bn | - |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 7.82 Bn |
| Mar 31, 2026 | 3.98 Bn |
| Dec 31, 2025 | 2.11 Bn |
| Sep 30, 2025 | 1.01 Bn |
| Jun 30, 2025 | 903.78 Mn |
| Mar 31, 2025 | 972.85 Mn |
| Dec 31, 2024 | 1.11 Bn |
| Sep 30, 2024 | 1.51 Bn |
| Jun 30, 2024 | 1.19 Bn |
| Mar 31, 2024 | 1.39 Bn |
| Dec 31, 2023 | 157.96 Mn |
| Sep 30, 2023 | 49.60 Mn |
| Jun 30, 2023 | 36.52 Mn |
| Mar 31, 2023 | 27.34 Mn |
| Dec 31, 2022 | 37.93 Mn |
| Sep 30, 2022 | 49.55 Mn |
| Jun 30, 2022 | 41.50 Mn |
| Mar 31, 2022 | 151.79 Mn |
| Dec 31, 2021 | 312.29 Mn |
| Sep 30, 2021 | 523.03 Mn |
API Access
Spyre Therapeutics Market Capitalization API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=market-capitalization&ticker=SYRE&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "market-capitalization", "ticker": "SYRE", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=market-capitalization&ticker=SYRE&period=max&api_key=YOUR_API_KEY");
const data = await res.json();