Spyre Therapeutics SYRE
NASDAQ SYRE
$88.11 +0.86 (+0.99%)
As of: Sep 4, 2026 · 2:22 PM EDT

Spyre Therapeutics (SYRE) EBT (2015 - 2026)

Spyre Therapeutics' (SYRE) quarterly EBT came in at -$69.0 million in Q1 2026, down 54.07% YoY from -$150.2 million in Q1 2025, and down 10.36% on a QoQ basis from -$62.5 million in Q4 2025.

Analysis

Spyre Therapeutics (SYRE) EBT (2015 - 2026) Analysis & Trends

Spyre Therapeutics (SYRE) has 12 years of EBT data on file, last reported at -$69.0 million in Q1 2026.

  • Quarterly EBT fell 54.07% year-over-year to -$69.0 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was -$179.4 million (up 14.12% YoY) and the FY2025 annual result came in at -$155.2 million, up 25.36% from the prior year.
  • EBT eased to -$69.0 million in Q1 2026, from -$62.5 million in the prior quarter.
  • In the past five years, EBT ranged from a high of -$11.2 million in Q3 2025 to a low of -$217.1 million in Q2 2023.
  • A 5-year average of -$50.3 million and a median of -$40.1 million in 2023 frame the typical range for EBT.
  • Annual changes were most pronounced in 2023 — EBT plunged 872.82% — and 2025, when it soared 83.8%.
  • Tracing SYRE's EBT over 5 years: stood at -$18.8 million in 2022, then sank by 236.35% to -$63.2 million in 2023, then rose by 10.9% to -$56.3 million in 2024, then decreased by 11.08% to -$62.5 million in 2025, then dropped by 10.36% to -$69.0 million in 2026.
  • The last three EBT figures came in at -$69.0 million (Q1 2026), -$62.5 million (Q4 2025), and -$11.2 million (Q3 2025), per Business Quant data.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBT (Qtr)
1 Vertex Pharmaceuticals 138.87 Bn 131.01 Bn 2.84 Bn 1.39 Bn
2 Regeneron Pharmaceuticals 85.57 Bn 77.57 Bn 3.93 Bn 1.53 Bn
3 Argenx Se 63.51 Bn 58.32 Bn 1.37 Bn 542.00 Mn
4 Moderna 58.19 Bn 53.05 Bn 52.00 Mn -767.00 Mn
5 Revolution Medicines 44.07 Bn 44.07 Bn - -644.37 Mn
6 BeOne Medicines 39.99 Bn 34.89 Bn 1.53 Bn 312.46 Mn
7 Alnylam Pharmaceuticals 35.38 Bn 32.07 Bn 992.69 Mn 177.81 Mn
8 Royalty Pharma 28.42 Bn 27.58 Bn - 81.49 Mn
9 Insmed 27.41 Bn 26.25 Bn 358.27 Mn -11.37 Mn
10 Spyre Therapeutics 7.47 Bn 7.47 Bn - -36.20 Mn
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 -36.20 Mn
Mar 31, 2026 -69.01 Mn
Dec 31, 2025 -62.53 Mn
Sep 30, 2025 -11.18 Mn
Jun 30, 2025 -36.72 Mn
Mar 31, 2025 -44.79 Mn
Dec 31, 2024 -56.30 Mn
Sep 30, 2024 -69.01 Mn
Jun 30, 2024 -38.84 Mn
Mar 31, 2024 -43.83 Mn
Dec 31, 2023 -63.18 Mn
Sep 30, 2023 -40.10 Mn
Jun 30, 2023 -217.07 Mn
Mar 31, 2023 -18.46 Mn
Dec 31, 2022 -18.78 Mn
Sep 30, 2022 -18.44 Mn
Jun 30, 2022 -22.31 Mn
Mar 31, 2022 -24.44 Mn
Dec 31, 2021 -20.42 Mn
Sep 30, 2021 -20.28 Mn