Spyre Therapeutics (SYRE) EBT (2015 - 2026)
Spyre Therapeutics' EBT was -$36.2 million in Q2 2026, compared with -$36.72 million a year earlier.
Powered by 
Analysis
Spyre Therapeutics (SYRE) EBT (2015 - 2026) Analysis & Trends
On a trailing twelve-month basis, Spyre Therapeutics' EBT was -$178.92 million through Jun 30, 2026; for FY2025, it was -$155.22 million.
- In earlier years, EBT was -$207.97 million in FY2024, -$338.82 million in FY2023, -$83.95 million in FY2022 and -$65.66 million in FY2021.
- Quarterly EBT has moved between -$217.07 million (Q2 2023) and -$11.18 million (Q3 2025) over five years.
- Per Business Quant data, SYRE's EBT in the three quarters before Q2 2026 was -$69.01 million (Q1 2026), -$62.53 million (Q4 2025) and -$11.18 million (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBT (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 645.01 Bn | 563.54 Bn | 17.26 Bn | 6.75 Bn |
| 2 | AbbVie | 465.23 Bn | 438.39 Bn | 12.70 Bn | 4.28 Bn |
| 3 | Merck | 368.40 Bn | 322.83 Bn | 12.21 Bn | -683.00 Mn |
| 4 | Novartis Ag | 278.02 Bn | 233.89 Bn | 11.24 Bn | 4.27 Bn |
| 5 | Astrazeneca | 254.57 Bn | 228.13 Bn | 12.86 Bn | 2.80 Bn |
| 6 | Amgen | 229.02 Bn | 184.42 Bn | 7.24 Bn | 2.77 Bn |
| 7 | Gilead Sciences | 187.74 Bn | 161.85 Bn | 6.22 Bn | -10.25 Bn |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | -653.00 Mn |
| 9 | Vertex Pharmaceuticals | 133.45 Bn | 105.45 Bn | 2.84 Bn | 1.39 Bn |
| 10 | Spyre Therapeutics | 7.46 Bn | 7.46 Bn | - | -36.20 Mn |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -36.20 Mn |
| Mar 31, 2026 | -69.01 Mn |
| Dec 31, 2025 | -62.53 Mn |
| Sep 30, 2025 | -11.18 Mn |
| Jun 30, 2025 | -36.72 Mn |
| Mar 31, 2025 | -44.79 Mn |
| Dec 31, 2024 | -56.30 Mn |
| Sep 30, 2024 | -69.01 Mn |
| Jun 30, 2024 | -38.84 Mn |
| Mar 31, 2024 | -43.83 Mn |
| Dec 31, 2023 | -63.18 Mn |
| Sep 30, 2023 | -40.10 Mn |
| Jun 30, 2023 | -217.07 Mn |
| Mar 31, 2023 | -18.46 Mn |
| Dec 31, 2022 | -18.78 Mn |
| Sep 30, 2022 | -18.44 Mn |
| Jun 30, 2022 | -22.31 Mn |
| Mar 31, 2022 | -24.44 Mn |
| Dec 31, 2021 | -20.42 Mn |
| Sep 30, 2021 | -20.28 Mn |
API Access
Spyre Therapeutics EBT API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=ebt&ticker=SYRE&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "ebt", "ticker": "SYRE", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=ebt&ticker=SYRE&period=max&api_key=YOUR_API_KEY");
const data = await res.json();