Spyre Therapeutics (SYRE) Enterprise Value (2016 - 2026)
Spyre Therapeutics' Enterprise Value was $6.67 billion in Q2 2026, compared with $377.2 million a year earlier and up 106.3% from the prior quarter.
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Analysis
Spyre Therapeutics (SYRE) Enterprise Value (2016 - 2026) Analysis & Trends
On a trailing twelve-month basis, Spyre Therapeutics' Enterprise Value was $4.69 billion through Jun 30, 2026; for FY2025, it was $1.35 billion, up 169.5% from FY2024.
- Enterprise Value shows a five-year compound annual growth rate of 42.4% (FY2020 to FY2025).
- In earlier years, Enterprise Value was $502.41 million in FY2024, -$181.31 million in FY2023, -$17.78 million in FY2022 and $219.16 million in FY2021 (-5.2%).
- The Q2 2026 figure marks the highest quarterly Enterprise Value in data going back to Q2 2016.
- Compared with a year earlier, Enterprise Value was higher in two of the last five quarters, with growth averaging 140.9%.
- The best year-over-year quarter for Enterprise Value over five years was Q1 2026 (growth of 692.9%); the worst was Q1 2022 (a decline of 78.4%).
- Per Business Quant data, SYRE's Enterprise Value in the three quarters before Q2 2026 was $3.24 billion (Q1 2026), $1.35 billion (Q4 2025) and $527.31 million (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) |
|---|---|---|---|---|
| 1 | Johnson & Johnson | 638.12 Bn | 556.64 Bn | 17.26 Bn |
| 2 | AbbVie | 462.60 Bn | 435.75 Bn | 12.70 Bn |
| 3 | Merck | 358.70 Bn | 313.13 Bn | 12.21 Bn |
| 4 | Novartis Ag | 272.16 Bn | 228.03 Bn | 11.24 Bn |
| 5 | Astrazeneca | 250.36 Bn | 223.92 Bn | 12.86 Bn |
| 6 | Amgen | 227.87 Bn | 183.27 Bn | 7.24 Bn |
| 7 | Gilead Sciences | 184.97 Bn | 159.08 Bn | 6.22 Bn |
| 8 | Pfizer | 162.61 Bn | 109.56 Bn | 10.94 Bn |
| 9 | Vertex Pharmaceuticals | 132.45 Bn | 104.46 Bn | 2.84 Bn |
| 10 | Spyre Therapeutics | 7.84 Bn | 7.84 Bn | - |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 6.67 Bn |
| Mar 31, 2026 | 3.24 Bn |
| Dec 31, 2025 | 1.35 Bn |
| Sep 30, 2025 | 527.31 Mn |
| Jun 30, 2025 | 377.20 Mn |
| Mar 31, 2025 | 408.03 Mn |
| Dec 31, 2024 | 502.41 Mn |
| Sep 30, 2024 | 1.10 Bn |
| Jun 30, 2024 | 767.92 Mn |
| Mar 31, 2024 | 904.72 Mn |
| Dec 31, 2023 | -181.31 Mn |
| Sep 30, 2023 | -154.00 Mn |
| Jun 30, 2023 | -198.84 Mn |
| Mar 31, 2023 | -11.14 Mn |
| Dec 31, 2022 | -17.78 Mn |
| Sep 30, 2022 | -24.13 Mn |
| Jun 30, 2022 | -47.05 Mn |
| Mar 31, 2022 | 85.07 Mn |
| Dec 31, 2021 | 219.16 Mn |
| Sep 30, 2021 | 410.60 Mn |
API Access
Spyre Therapeutics Enterprise Value API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=enterprise-value&ticker=SYRE&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "enterprise-value", "ticker": "SYRE", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=enterprise-value&ticker=SYRE&period=max&api_key=YOUR_API_KEY");
const data = await res.json();