Spyre Therapeutics (SYRE) Short term Debt (2023 - 2026)

Spyre Therapeutics posted quarterly Short term Debt of $50.3 million for Q1 2026, up 17.4% year-on-year from $42.8 million in Q1 2025, and up 120.25% on a QoQ basis from $22.8 million in Q4 2025.

Spyre Therapeutics (SYRE) has 4 years of Short term Debt data on file, last reported at $50.3 million in Q1 2026.

  • For the quarter ending Q1 2026, Short term Debt rose 17.4% year-over-year to $50.3 million; the trailing twelve-month figure through Mar 2026 stood at $50.3 million (up 17.4% YoY), and the FY2025 full-year result was $22.8 million, down 9.01% from the prior year.
  • Short term Debt for Q1 2026 stood at $50.3 million, up from $22.8 million in the prior quarter.
  • Across five years, Short term Debt topped out at $164.4 million in Q2 2023 and bottomed at $1.4 million in Q4 2023.
  • The 4-year median for Short term Debt is $23.8 million (2024), against an average of $34.6 million.
  • The widest annual swing landed in 2024, when Short term Debt slumped 98.39%; it then jumped 2168.94% in 2025.
  • A 4-year view of Short term Debt shows it stood at $1.4 million in 2023, then jumped by 1704.32% to $25.1 million in 2024, then dropped by 9.01% to $22.8 million in 2025, then soared by 120.25% to $50.3 million in 2026.
  • The last three Short term Debt figures came in at $50.3 million (Q1 2026), $22.8 million (Q4 2025), and $11.0 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn -
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn -
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn
7 Evaxion A 62.56 Bn 62.54 Bn -
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn
10 Spyre Therapeutics 5.55 Bn 5.55 Bn -

Historic Data

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DateValue
Mar 31, 2026 50.26 Mn
Dec 31, 2025 22.82 Mn
Sep 30, 2025 11.02 Mn
Jun 30, 2025 59.90 Mn
Mar 31, 2025 42.81 Mn
Dec 31, 2024 25.08 Mn
Sep 30, 2024 24.74 Mn
Jun 30, 2024 2.64 Mn
Mar 31, 2024 2.59 Mn
Dec 31, 2023 1.39 Mn
Sep 30, 2023 7.51 Mn
Jun 30, 2023 164.38 Mn