Spyre Therapeutics SYRE
NASDAQ SYRE
$86.55 -0.70 (-0.80%)
As of: Sep 4, 2026 · 12:50 PM EDT

Spyre Therapeutics (SYRE) Non Operating Income (2015 - 2026)

Spyre Therapeutics' (SYRE) quarterly Non Operating Income came in at -$23.4 million in Q1 2026, down 366.14% YoY from $8.8 million in Q1 2025, and down 336.06% on a QoQ basis from -$5.4 million in Q4 2025.

Analysis

Spyre Therapeutics (SYRE) Non Operating Income (2015 - 2026) Analysis & Trends

Spyre Therapeutics (SYRE) has 12 years of Non Operating Income data on file, last reported at -$23.4 million in Q1 2026.

  • Quarterly Non Operating Income fell 366.14% year-over-year to -$23.4 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was $22.2 million (up 308.93% YoY) and the FY2025 annual result came in at $54.3 million, up 8972.45% from the prior year.
  • Non Operating Income slipped to -$23.4 million in Q1 2026, from -$5.4 million in the prior quarter.
  • In the past five years, Non Operating Income ranged from a high of $45.7 million in Q3 2025 to a low of -$57.8 million in Q2 2023.
  • A 5-year average of -$3.8 million and a median of $312000.0 in 2022 frame the typical range for Non Operating Income.
  • The widest YoY moves for Non Operating Income: up 6860.0% in 2023, down 53153.21% in 2023.
  • Tracing SYRE's Non Operating Income over 5 years: stood at $378000.0 in 2022, then slumped by 4667.72% to -$17.3 million in 2023, then jumped by 128.72% to $5.0 million in 2024, then tumbled by 208.07% to -$5.4 million in 2025, then plunged by 336.06% to -$23.4 million in 2026.
  • The last three Non Operating Income figures came in at -$23.4 million (Q1 2026), -$5.4 million (Q4 2025), and $45.7 million (Q3 2025), per Business Quant data.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Non Op. Inc. (Qtr)
1 Vertex Pharmaceuticals 139.62 Bn 131.77 Bn 2.84 Bn -
2 Regeneron Pharmaceuticals 85.73 Bn 77.73 Bn 3.93 Bn 234.30 Mn
3 Argenx Se 63.53 Bn 58.35 Bn 1.37 Bn -
4 Moderna 58.23 Bn 53.09 Bn 52.00 Mn -
5 Revolution Medicines 44.05 Bn 44.05 Bn - -139.24 Mn
6 BeOne Medicines 40.03 Bn 34.93 Bn 1.53 Bn -
7 Alnylam Pharmaceuticals 35.50 Bn 32.19 Bn 992.69 Mn -53.64 Mn
8 Royalty Pharma 28.52 Bn 27.68 Bn - -51.63 Mn
9 Insmed 27.46 Bn 26.30 Bn 358.27 Mn -
10 Spyre Therapeutics 7.35 Bn 7.35 Bn - 5.44 Mn
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 5.44 Mn
Mar 31, 2026 -23.36 Mn
Dec 31, 2025 -5.36 Mn
Sep 30, 2025 45.71 Mn
Jun 30, 2025 5.22 Mn
Mar 31, 2025 8.78 Mn
Dec 31, 2024 4.96 Mn
Sep 30, 2024 -13.62 Mn
Jun 30, 2024 5.31 Mn
Mar 31, 2024 3.95 Mn
Dec 31, 2023 -17.27 Mn
Sep 30, 2023 -21.77 Mn
Jun 30, 2023 -57.83 Mn
Mar 31, 2023 348,000.00
Dec 31, 2022 378,000.00
Sep 30, 2022 312,000.00
Jun 30, 2022 109,000.00
Mar 31, 2022 5,000.00
Dec 31, 2021 19,000.00
Sep 30, 2021 12,000.00