Spyre Therapeutics (SYRE) Debt Ratio (2023 - 2026)
Spyre Therapeutics posted quarterly Debt Ratio of 0.07 for Q1 2026, down 12.44% year-on-year from 0.08 in Q1 2025, and up 124.23% on a QoQ basis from 0.03 in Q4 2025.
Spyre Therapeutics (SYRE) has 4 years of Debt Ratio data on file, last reported at 0.07 in Q1 2026.
- For the quarter ending Q1 2026, Debt Ratio fell 12.44% year-over-year to 0.07; the trailing twelve-month figure through Mar 2026 stood at 0.07 (down 12.44% YoY), and the FY2025 full-year result was 0.03, down 28.82% from the prior year.
- Debt Ratio for Q1 2026 stood at 0.07, up from 0.03 in the prior quarter.
- Across five years, Debt Ratio topped out at 0.67 in Q2 2023 and bottomed at 0.0 in Q4 2023.
- The 4-year median for Debt Ratio is 0.04 (2024), against an average of 0.09.
- The widest annual swing landed in 2024, when Debt Ratio sank 99.1%; it then jumped 1736.21% in 2025.
- A 4-year view of Debt Ratio shows it stood at 0.0 in 2023, then jumped by 913.7% to 0.04 in 2024, then decreased by 28.82% to 0.03 in 2025, then soared by 124.23% to 0.07 in 2026.
- The last three Debt Ratio figures came in at 0.07 (Q1 2026), 0.03 (Q4 2025), and 0.02 (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Debt Ratio (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | - |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | 0.18 |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | 1.41 |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | - |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 0.05 |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | - |
| 10 | Spyre Therapeutics | 5.55 Bn | 5.55 Bn | - | 0.07 |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 0.07 |
| Dec 31, 2025 | 0.03 |
| Sep 30, 2025 | 0.02 |
| Jun 30, 2025 | 0.11 |
| Mar 31, 2025 | 0.08 |
| Dec 31, 2024 | 0.04 |
| Sep 30, 2024 | 0.06 |
| Jun 30, 2024 | 0.01 |
| Mar 31, 2024 | 0.01 |
| Dec 31, 2023 | 0.00 |
| Sep 30, 2023 | 0.04 |
| Jun 30, 2023 | 0.67 |