Spyre Therapeutics (SYRE) Cash from Operations (2015 - 2026)
Spyre Therapeutics (SYRE) reported Cash from Operations of 57372000.0 for Q1 2026, down 39.95% on a YoY basis from 95543864.48 in Q1 2025, and down 28.7% quarter-over-quarter from 44578000.0 in Q4 2025.
Spyre Therapeutics (SYRE) Cash from Operations (2015 - 2026) Analysis & Trends
Spyre Therapeutics has reported Cash from Operations for 12 years, with the latest figure at 57372000.0 in Q1 2026.
- For the quarter ending Q1 2026, Cash from Operations fell 39.95% year-over-year to 57372000.0; the trailing twelve-month figure through Mar 2026 stood at 185630000.0 (down 9.28% YoY), and the FY2025 full-year result was 169252000.0, down 7.52% from the prior year.
- Cash from Operations for Q1 2026 stood at 57372000.0, down from 44578000.0 in the prior quarter.
- The five-year high for Cash from Operations was 15068000.0 in Q3 2022, with the low at 62248000.0 in Q2 2024.
- Historically, Cash from Operations has averaged 33181647.06 across 5 years, with a median of 31036000.0 in 2023.
- Annual changes were most pronounced in 2022 — Cash from Operations sank 1092.94% — and 2023, when it soared 32.86%.
- Spyre Therapeutics' Cash from Operations stood at 18140000.0 in 2022, then slumped by 71.09% to 31036000.0 in 2023, then decreased by 19.86% to 37199000.0 in 2024, then retreated by 19.84% to 44578000.0 in 2025, then declined by 28.7% to 57372000.0 in 2026.
- The last three Cash from Operations figures came in at 57372000.0 (Q1 2026), 44578000.0 (Q4 2025), and 37117000.0 (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Cash from Ops. (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | -1.67 Mn |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -12.20 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | -2.49 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 1.43 Bn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | - |
| 10 | Spyre Therapeutics | 6.95 Bn | 6.95 Bn | - | -57.37 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -57.37 Mn |
| Mar 31, 2026 | -57.37 Mn |
| Dec 31, 2025 | -44.58 Mn |
| Dec 31, 2025 | -44.58 Mn |
| Sep 30, 2025 | -37.12 Mn |
| Sep 30, 2025 | -37.12 Mn |
| Jun 30, 2025 | -46.56 Mn |
| Jun 30, 2025 | -46.56 Mn |
| Mar 31, 2025 | -40.99 Mn |
| Mar 31, 2025 | -40.99 Mn |
| Dec 31, 2024 | -37.20 Mn |
| Dec 31, 2024 | -37.20 Mn |
| Sep 30, 2024 | -29.42 Mn |
| Sep 30, 2024 | -29.42 Mn |
| Jun 30, 2024 | -62.25 Mn |
| Jun 30, 2024 | -62.25 Mn |
| Mar 31, 2024 | -28.54 Mn |
| Mar 31, 2024 | -28.54 Mn |
| Dec 31, 2023 | -31.04 Mn |
| Dec 31, 2023 | -31.04 Mn |