Spyre Therapeutics (SYRE) Cash from Operations (2015 - 2026)
Spyre Therapeutics posted quarterly Cash from Operations of 57372000.0 for Q1 2026, down 39.95% year-on-year from 95543864.48 in Q1 2025, and down 28.7% on a QoQ basis from 44578000.0 in Q4 2025.
Spyre Therapeutics (SYRE) has 12 years of Cash from Operations data on file, last reported at 57372000.0 in Q1 2026.
- For the quarter ending Q1 2026, Cash from Operations fell 39.95% year-over-year to 57372000.0; the trailing twelve-month figure through Mar 2026 stood at 185630000.0 (down 9.28% YoY), and the FY2025 full-year result was 169252000.0, down 7.52% from the prior year.
- Cash from Operations for Q1 2026 stood at 57372000.0, down from 44578000.0 in the prior quarter.
- Across five years, Cash from Operations topped out at 15068000.0 in Q3 2022 and bottomed at 62248000.0 in Q2 2024.
- The 5-year median for Cash from Operations is 31036000.0 (2023), against an average of 33181647.06.
- The widest annual swing landed in 2022, when Cash from Operations tumbled 1092.94%; it then soared 32.86% in 2023.
- A 5-year view of Cash from Operations shows it stood at 18140000.0 in 2022, then sank by 71.09% to 31036000.0 in 2023, then slipped by 19.86% to 37199000.0 in 2024, then decreased by 19.84% to 44578000.0 in 2025, then fell by 28.7% to 57372000.0 in 2026.
- The last three Cash from Operations figures came in at 57372000.0 (Q1 2026), 44578000.0 (Q4 2025), and 37117000.0 (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Cash from Operations (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | -1.67 Mn |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | -12.20 Mn |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | -2.49 Mn |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 1.43 Bn |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 1.08 Bn |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 70.50 Mn |
| 10 | Spyre Therapeutics | 5.55 Bn | 5.55 Bn | - | -57.37 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -57.37 Mn |
| Mar 31, 2026 | -57.37 Mn |
| Dec 31, 2025 | -44.58 Mn |
| Dec 31, 2025 | -44.58 Mn |
| Sep 30, 2025 | -37.12 Mn |
| Sep 30, 2025 | -37.12 Mn |
| Jun 30, 2025 | -46.56 Mn |
| Jun 30, 2025 | -46.56 Mn |
| Mar 31, 2025 | -40.99 Mn |
| Mar 31, 2025 | -40.99 Mn |
| Dec 31, 2024 | -37.20 Mn |
| Dec 31, 2024 | -37.20 Mn |
| Sep 30, 2024 | -29.42 Mn |
| Sep 30, 2024 | -29.42 Mn |
| Jun 30, 2024 | -62.25 Mn |
| Jun 30, 2024 | -62.25 Mn |
| Mar 31, 2024 | -28.54 Mn |
| Mar 31, 2024 | -28.54 Mn |
| Dec 31, 2023 | -31.04 Mn |
| Dec 31, 2023 | -31.04 Mn |
| Sep 30, 2023 | -34.60 Mn |
| Sep 30, 2023 | -34.60 Mn |
| Jun 30, 2023 | -16.64 Mn |
| Jun 30, 2023 | -16.64 Mn |
| Mar 31, 2023 | -17.63 Mn |
| Mar 31, 2023 | -17.63 Mn |
| Dec 31, 2022 | -18.14 Mn |
| Dec 31, 2022 | -18.14 Mn |
| Sep 30, 2022 | -15.07 Mn |
| Sep 30, 2022 | -15.07 Mn |
| Jun 30, 2022 | -20.67 Mn |
| Jun 30, 2022 | -20.67 Mn |
| Mar 31, 2022 | -26.26 Mn |
| Mar 31, 2022 | -26.26 Mn |
| Dec 31, 2021 | -19.27 Mn |
| Dec 31, 2021 | -19.27 Mn |
| Sep 30, 2021 | -17.00 Mn |
| Sep 30, 2021 | -17.00 Mn |
| Jun 30, 2021 | 2.08 Mn |
| Jun 30, 2021 | 2.08 Mn |
| Mar 31, 2021 | -19.53 Mn |
| Mar 31, 2021 | -19.53 Mn |
| Dec 31, 2020 | -17.13 Mn |
| Dec 31, 2020 | -17.13 Mn |
| Sep 30, 2020 | -17.54 Mn |
| Sep 30, 2020 | -17.54 Mn |
| Jun 30, 2020 | -19.41 Mn |
| Jun 30, 2020 | -19.41 Mn |
| Mar 31, 2020 | -21.69 Mn |
| Mar 31, 2020 | -21.69 Mn |
| Dec 31, 2019 | -16.29 Mn |
| Dec 31, 2019 | -16.29 Mn |
| Sep 30, 2019 | -17.21 Mn |
| Sep 30, 2019 | -17.21 Mn |
| Jun 30, 2019 | -16.38 Mn |
| Jun 30, 2019 | -16.38 Mn |
| Mar 31, 2019 | -15.81 Mn |
| Mar 31, 2019 | -15.81 Mn |
| Dec 31, 2018 | -7.20 Mn |
| Dec 31, 2018 | -7.20 Mn |
| Sep 30, 2018 | -8.50 Mn |
| Sep 30, 2018 | -8.50 Mn |
| Jun 30, 2018 | -9.04 Mn |
| Jun 30, 2018 | -9.04 Mn |
| Mar 31, 2018 | -7.45 Mn |
| Mar 31, 2018 | -7.45 Mn |
| Dec 31, 2017 | -5.87 Mn |
| Dec 31, 2017 | -5.87 Mn |
| Sep 30, 2017 | -7.37 Mn |
| Sep 30, 2017 | -7.37 Mn |
| Jun 30, 2017 | -5.94 Mn |
| Jun 30, 2017 | -5.94 Mn |
| Mar 31, 2017 | -5.43 Mn |
| Mar 31, 2017 | -5.43 Mn |
| Dec 31, 2016 | -4.36 Mn |
| Dec 31, 2016 | -4.36 Mn |
| Sep 30, 2016 | -5.87 Mn |
| Sep 30, 2016 | -5.87 Mn |
| Jun 30, 2016 | -4.63 Mn |
| Jun 30, 2016 | -4.63 Mn |
| Mar 31, 2016 | -3.99 Mn |
| Mar 31, 2016 | -3.99 Mn |
| Dec 31, 2015 | -833,000.00 |
| Dec 31, 2015 | -833,000.00 |
| Sep 30, 2015 | -3.81 Mn |
| Sep 30, 2015 | -3.81 Mn |
| Jun 30, 2015 | -3.86 Mn |
| Jun 30, 2015 | -3.86 Mn |
| Mar 31, 2015 | -2.48 Mn |
| Mar 31, 2015 | -2.48 Mn |