Spyre Therapeutics (SYRE) Cash from Operations (2015 - 2026)

Spyre Therapeutics (SYRE) reported Cash from Operations of 57372000.0 for Q1 2026, down 39.95% on a YoY basis from 95543864.48 in Q1 2025, and down 28.7% quarter-over-quarter from 44578000.0 in Q4 2025.

Spyre Therapeutics (SYRE) Cash from Operations (2015 - 2026) Analysis & Trends

Spyre Therapeutics has reported Cash from Operations for 12 years, with the latest figure at 57372000.0 in Q1 2026.

  • For the quarter ending Q1 2026, Cash from Operations fell 39.95% year-over-year to 57372000.0; the trailing twelve-month figure through Mar 2026 stood at 185630000.0 (down 9.28% YoY), and the FY2025 full-year result was 169252000.0, down 7.52% from the prior year.
  • Cash from Operations for Q1 2026 stood at 57372000.0, down from 44578000.0 in the prior quarter.
  • The five-year high for Cash from Operations was 15068000.0 in Q3 2022, with the low at 62248000.0 in Q2 2024.
  • Historically, Cash from Operations has averaged 33181647.06 across 5 years, with a median of 31036000.0 in 2023.
  • Annual changes were most pronounced in 2022 — Cash from Operations sank 1092.94% — and 2023, when it soared 32.86%.
  • Spyre Therapeutics' Cash from Operations stood at 18140000.0 in 2022, then slumped by 71.09% to 31036000.0 in 2023, then decreased by 19.86% to 37199000.0 in 2024, then retreated by 19.84% to 44578000.0 in 2025, then declined by 28.7% to 57372000.0 in 2026.
  • The last three Cash from Operations figures came in at 57372000.0 (Q1 2026), 44578000.0 (Q4 2025), and 37117000.0 (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Cash from Ops. (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -1.67 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -12.20 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -2.49 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.43 Bn
9 Abivax 91.96 Bn 91.96 Bn - -
10 Spyre Therapeutics 6.95 Bn 6.95 Bn - -57.37 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -57.37 Mn
Mar 31, 2026 -57.37 Mn
Dec 31, 2025 -44.58 Mn
Dec 31, 2025 -44.58 Mn
Sep 30, 2025 -37.12 Mn
Sep 30, 2025 -37.12 Mn
Jun 30, 2025 -46.56 Mn
Jun 30, 2025 -46.56 Mn
Mar 31, 2025 -40.99 Mn
Mar 31, 2025 -40.99 Mn
Dec 31, 2024 -37.20 Mn
Dec 31, 2024 -37.20 Mn
Sep 30, 2024 -29.42 Mn
Sep 30, 2024 -29.42 Mn
Jun 30, 2024 -62.25 Mn
Jun 30, 2024 -62.25 Mn
Mar 31, 2024 -28.54 Mn
Mar 31, 2024 -28.54 Mn
Dec 31, 2023 -31.04 Mn
Dec 31, 2023 -31.04 Mn