Spyre Therapeutics (SYRE) Shares Outstanding (Diluted Average) (2020 - 2026)

Spyre Therapeutics posted quarterly Shares Outstanding (Diluted Average) of $346045.0 for Q1 2026, down 99.43% year-on-year from $60.3 million in Q1 2025, and down 99.46% on a QoQ basis from $64.1 million in Q4 2025.

Spyre Therapeutics (SYRE) has 7 years of Shares Outstanding (Diluted Average) data on file, last reported at $346045.0 in Q1 2026.

  • For the quarter ending Q1 2026, Shares Outstanding (Diluted Average) fell 99.43% year-over-year to $346045.0; the trailing twelve-month figure through Mar 2026 stood at $346045.0 (down 99.43% YoY), and the FY2025 full-year result was $64.1 million, up 36.21% from the prior year.
  • Shares Outstanding (Diluted Average) for Q1 2026 stood at $346045.0, down from $64.1 million in the prior quarter.
  • Across five years, Shares Outstanding (Diluted Average) topped out at $82.2 million in Q2 2022 and bottomed at $346045.0 in Q2 2025.
  • The 5-year median for Shares Outstanding (Diluted Average) is $5.6 million (2023), against an average of $26.8 million.
  • The widest annual swing landed in 2025, when Shares Outstanding (Diluted Average) surged 13689.66%; it then sank 99.43% in 2026.
  • A 5-year view of Shares Outstanding (Diluted Average) shows it stood at $3.2 million in 2022, then surged by 114.0% to $6.9 million in 2023, then surged by 581.85% to $47.0 million in 2024, then jumped by 36.21% to $64.1 million in 2025, then plunged by 99.46% to $346045.0 in 2026.
  • The last three Shares Outstanding (Diluted Average) figures came in at $346045.0 (Q1 2026), $64.1 million (Q4 2025), and $346045.0 (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Shares (Diluted Avg.) (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - 3.06 Mn
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn 810.00
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - 118.76 Bn
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 256.30 Mn
7 Evaxion A 62.56 Bn 62.54 Bn - -
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 107.70 Mn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 138.23 Mn
10 Spyre Therapeutics 5.55 Bn 5.55 Bn - 346,045.00

Historic Data

Download Data 🔒
DateValue
Mar 31, 2026 346,045.00
Dec 31, 2025 64.06 Mn
Sep 30, 2025 346,045.00
Jun 30, 2025 346,045.00
Mar 31, 2025 60.27 Mn
Dec 31, 2024 47.03 Mn
Sep 30, 2024 44.26 Mn
Jun 30, 2024 40.91 Mn
Mar 31, 2024 437,037.00
Dec 31, 2023 6.90 Mn
Sep 30, 2023 4.29 Mn
Jun 30, 2023 3.80 Mn
Mar 31, 2023 3.77 Mn
Sep 30, 2022 3.22 Mn
Jun 30, 2022 82.21 Mn
Mar 31, 2022 66.00 Mn
Dec 31, 2021 2.63 Mn
Sep 30, 2021 65.68 Mn
Jun 30, 2021 65.63 Mn
Dec 31, 2020 53.37 Mn