Spyre Therapeutics (SYRE) Change in Accured Expenses (2015 - 2026)
Spyre Therapeutics posted quarterly Change in Accured Expenses of $3.7 million for Q1 2026, up 160.9% year-on-year from $1.4 million in Q1 2025, and up 16.93% on a QoQ basis from $3.1 million in Q4 2025.
Spyre Therapeutics (SYRE) has 12 years of Change in Accured Expenses data on file, last reported at $3.7 million in Q1 2026.
- For the quarter ending Q1 2026, Change in Accured Expenses rose 160.9% year-over-year to $3.7 million; the trailing twelve-month figure through Mar 2026 stood at $8.9 million (up 1831.96% YoY), and the FY2025 full-year result was -$764000.0, down 105.23% from the prior year.
- Change in Accured Expenses for Q1 2026 stood at $3.7 million, up from $3.1 million in the prior quarter.
- Across five years, Change in Accured Expenses topped out at $14.9 million in Q4 2024 and bottomed at -$15.8 million in Q2 2024.
- The 5-year median for Change in Accured Expenses is $450000.0 (2022), against an average of $692000.0.
- Peak annual rise in Change in Accured Expenses reached 1768.46% in 2024, while the deepest fall reached 849.0% in 2024.
- A 5-year view of Change in Accured Expenses shows it stood at $450000.0 in 2022, then slumped by 298.0% to -$891000.0 in 2023, then soared by 1768.46% to $14.9 million in 2024, then slumped by 78.99% to $3.1 million in 2025, then gained by 16.93% to $3.7 million in 2026.
- The last three Change in Accured Expenses figures came in at $3.7 million (Q1 2026), $3.1 million (Q4 2025), and $4.4 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Change in Accured Expenses (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | - |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | - |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | 931,000.00 |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 70.50 Mn |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 107.70 Mn |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | -176.03 Mn |
| 10 | Spyre Therapeutics | 5.55 Bn | 5.55 Bn | - | 3.65 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 3.65 Mn |
| Mar 31, 2026 | 3.65 Mn |
| Dec 31, 2025 | 3.12 Mn |
| Dec 31, 2025 | 3.12 Mn |
| Sep 30, 2025 | 4.41 Mn |
| Sep 30, 2025 | 4.41 Mn |
| Jun 30, 2025 | -2.30 Mn |
| Jun 30, 2025 | -2.30 Mn |
| Mar 31, 2025 | -6.00 Mn |
| Mar 31, 2025 | -6.00 Mn |
| Dec 31, 2024 | 14.87 Mn |
| Dec 31, 2024 | 14.87 Mn |
| Sep 30, 2024 | 7.37 Mn |
| Sep 30, 2024 | 7.37 Mn |
| Jun 30, 2024 | -15.77 Mn |
| Jun 30, 2024 | -15.77 Mn |
| Mar 31, 2024 | 8.15 Mn |
| Mar 31, 2024 | 8.15 Mn |
| Dec 31, 2023 | -891,000.00 |
| Dec 31, 2023 | -891,000.00 |
| Sep 30, 2023 | -2.94 Mn |
| Sep 30, 2023 | -2.94 Mn |
| Jun 30, 2023 | 2.11 Mn |
| Jun 30, 2023 | 2.11 Mn |
| Mar 31, 2023 | -3.16 Mn |
| Mar 31, 2023 | -3.16 Mn |
| Dec 31, 2022 | 450,000.00 |
| Dec 31, 2022 | 450,000.00 |
| Sep 30, 2022 | -416,000.00 |
| Sep 30, 2022 | -416,000.00 |
| Jun 30, 2022 | 2.26 Mn |
| Jun 30, 2022 | 2.26 Mn |
| Mar 31, 2022 | -3.14 Mn |
| Mar 31, 2022 | -3.14 Mn |
| Dec 31, 2021 | 455,000.00 |
| Dec 31, 2021 | 455,000.00 |
| Sep 30, 2021 | 1.04 Mn |
| Sep 30, 2021 | 1.04 Mn |
| Jun 30, 2021 | 833,000.00 |
| Jun 30, 2021 | 833,000.00 |
| Mar 31, 2021 | -2.70 Mn |
| Mar 31, 2021 | -2.70 Mn |
| Dec 31, 2020 | 2.48 Mn |
| Dec 31, 2020 | 2.48 Mn |
| Sep 30, 2020 | 320,000.00 |
| Sep 30, 2020 | 320,000.00 |
| Jun 30, 2020 | -1.88 Mn |
| Jun 30, 2020 | -1.88 Mn |
| Mar 31, 2020 | -2.07 Mn |
| Mar 31, 2020 | -2.07 Mn |
| Dec 31, 2019 | 1.82 Mn |
| Dec 31, 2019 | 1.82 Mn |
| Sep 30, 2019 | 2.71 Mn |
| Sep 30, 2019 | 2.71 Mn |
| Jun 30, 2019 | 1.70 Mn |
| Jun 30, 2019 | 1.70 Mn |
| Mar 31, 2019 | -1.11 Mn |
| Mar 31, 2019 | -1.11 Mn |
| Dec 31, 2018 | 2.98 Mn |
| Dec 31, 2018 | 2.98 Mn |
| Sep 30, 2018 | 1.22 Mn |
| Sep 30, 2018 | 1.22 Mn |
| Jun 30, 2018 | 185,000.00 |
| Jun 30, 2018 | 185,000.00 |
| Mar 31, 2018 | -217,000.00 |
| Mar 31, 2018 | -217,000.00 |
| Dec 31, 2017 | 1.18 Mn |
| Dec 31, 2017 | 1.18 Mn |
| Sep 30, 2017 | 559,000.00 |
| Sep 30, 2017 | 559,000.00 |
| Jun 30, 2017 | 14,000.00 |
| Jun 30, 2017 | 14,000.00 |
| Mar 31, 2017 | -87,000.00 |
| Mar 31, 2017 | -87,000.00 |
| Dec 31, 2016 | 520,000.00 |
| Dec 31, 2016 | 520,000.00 |
| Sep 30, 2016 | 135,000.00 |
| Sep 30, 2016 | 135,000.00 |
| Jun 30, 2016 | 699,000.00 |
| Jun 30, 2016 | 699,000.00 |
| Mar 31, 2016 | 475,000.00 |
| Mar 31, 2016 | 475,000.00 |
| Dec 31, 2015 | 501,000.00 |
| Dec 31, 2015 | 501,000.00 |
| Sep 30, 2015 | 599,000.00 |
| Sep 30, 2015 | 599,000.00 |
| Jun 30, 2015 | 93,000.00 |
| Jun 30, 2015 | 93,000.00 |
| Mar 31, 2015 | -74,000.00 |
| Mar 31, 2015 | -74,000.00 |