Spyre Therapeutics (SYRE) Cash & Equivalents (2015 - 2026)

Spyre Therapeutics posted quarterly Cash & Equivalents of $97.2 million for Q1 2026, up 107.66% year-on-year from $46.8 million in Q1 2025, and up 13.37% on a QoQ basis from $85.7 million in Q4 2025.

Spyre Therapeutics (SYRE) has 12 years of Cash & Equivalents data on file, last reported at $97.2 million in Q1 2026.

  • For the quarter ending Q1 2026, Cash & Equivalents rose 107.66% year-over-year to $97.2 million; the trailing twelve-month figure through Mar 2026 stood at $97.2 million (up 107.66% YoY), and the FY2025 full-year result was $85.7 million, down 2.29% from the prior year.
  • Cash & Equivalents for Q1 2026 stood at $97.2 million, up from $85.7 million in the prior quarter.
  • Across five years, Cash & Equivalents topped out at $235.4 million in Q2 2023 and bottomed at $14.6 million in Q1 2022.
  • The 5-year median for Cash & Equivalents is $69.9 million (2024), against an average of $87.2 million.
  • The widest annual swing landed in 2022, when Cash & Equivalents slumped 81.76%; it then surged 545.67% in 2024.
  • A 5-year view of Cash & Equivalents shows it stood at $34.9 million in 2022, then soared by 441.82% to $188.9 million in 2023, then tumbled by 53.55% to $87.7 million in 2024, then retreated by 2.29% to $85.7 million in 2025, then gained by 13.37% to $97.2 million in 2026.
  • The last three Cash & Equivalents figures came in at $97.2 million (Q1 2026), $85.7 million (Q4 2025), and $64.9 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Cash & Equiv. (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - 1.91 Mn
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - 32.30 Mn
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn 286.70 Mn
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - 61.46 Mn
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - 2.77 Mn
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 5.49 Bn
7 Evaxion A 62.56 Bn 62.54 Bn - 18.44 Mn
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 2.96 Bn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 1.71 Bn
10 Spyre Therapeutics 5.55 Bn 5.55 Bn - 97.19 Mn

Historic Data

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DateValue
Mar 31, 2026 97.19 Mn
Dec 31, 2025 85.72 Mn
Sep 30, 2025 64.90 Mn
Jun 30, 2025 81.66 Mn
Mar 31, 2025 46.80 Mn
Dec 31, 2024 87.73 Mn
Sep 30, 2024 69.90 Mn
Jun 30, 2024 45.14 Mn
Mar 31, 2024 227.55 Mn
Dec 31, 2023 188.89 Mn
Sep 30, 2023 90.59 Mn
Jun 30, 2023 235.36 Mn
Mar 31, 2023 35.24 Mn
Dec 31, 2022 34.86 Mn
Sep 30, 2022 38.99 Mn
Jun 30, 2022 37.47 Mn
Mar 31, 2022 14.64 Mn
Dec 31, 2021 15.14 Mn
Sep 30, 2021 24.67 Mn
Jun 30, 2021 34.77 Mn
Mar 31, 2021 80.23 Mn
Dec 31, 2020 90.10 Mn
Sep 30, 2020 54.22 Mn
Jun 30, 2020 65.71 Mn
Mar 31, 2020 12.59 Mn
Dec 31, 2019 19.25 Mn
Sep 30, 2019 24.55 Mn
Jun 30, 2019 25.43 Mn
Mar 31, 2019 26.84 Mn
Dec 31, 2018 22.46 Mn
Sep 30, 2018 12.80 Mn
Jun 30, 2018 20.58 Mn
Mar 31, 2018 7.62 Mn
Dec 31, 2017 12.82 Mn
Sep 30, 2017 11.21 Mn
Jun 30, 2017 26.93 Mn
Mar 31, 2017 16.80 Mn
Dec 31, 2016 47.75 Mn
Sep 30, 2016 49.54 Mn
Jun 30, 2016 70.63 Mn
Mar 31, 2016 24.02 Mn
Dec 31, 2015 29.29 Mn
Sep 30, 2015 30.84 Mn
Jun 30, 2015 39.08 Mn
Mar 31, 2015 43.79 Mn