Spyre Therapeutics (SYRE) Cash from Investing Activities (2015 - 2026)
Spyre Therapeutics posted quarterly Cash from Investing Activities of $56.6 million for Q1 2026, up 92855.74% year-on-year from N/an in Q1 2025, and up 122.87% on a QoQ basis from -$247.4 million in Q4 2025.
Spyre Therapeutics (SYRE) has 12 years of Cash from Investing Activities data on file, last reported at $56.6 million in Q1 2026.
- For the quarter ending Q1 2026, Cash from Investing Activities rose 92855.74% year-over-year to $56.6 million; the trailing twelve-month figure through Mar 2026 stood at -$86.8 million (up 65.04% YoY), and the FY2025 full-year result was -$143.5 million, up 59.39% from the prior year.
- Cash from Investing Activities for Q1 2026 stood at $56.6 million, up from -$247.4 million in the prior quarter.
- Across five years, Cash from Investing Activities topped out at $79.0 million in Q2 2025 and bottomed at -$247.4 million in Q4 2025.
- The 5-year median for Cash from Investing Activities is $6.8 million (2023), against an average of -$28.9 million.
- The widest annual swing landed in 2024, when Cash from Investing Activities tumbled 1882.81%; it then soared 92855.74% in 2026.
- A 5-year view of Cash from Investing Activities shows it stood at $14.0 million in 2022, then slumped by 351.94% to -$35.3 million in 2023, then slumped by 383.51% to -$170.5 million in 2024, then slumped by 45.07% to -$247.4 million in 2025, then jumped by 122.87% to $56.6 million in 2026.
- The last three Cash from Investing Activities figures came in at $56.6 million (Q1 2026), -$247.4 million (Q4 2025), and $25.0 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Cash from Investing Activities (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | -2.89 Mn |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | 638.50 Mn |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | -431.90 Mn |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | -428.90 Mn |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | -25.54 Mn |
| 10 | Spyre Therapeutics | 5.55 Bn | 5.55 Bn | - | 56.58 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 56.58 Mn |
| Mar 31, 2026 | 56.58 Mn |
| Dec 31, 2025 | -247.41 Mn |
| Dec 31, 2025 | -247.41 Mn |
| Sep 30, 2025 | 25.00 Mn |
| Sep 30, 2025 | 25.00 Mn |
| Jun 30, 2025 | 79.00 Mn |
| Jun 30, 2025 | 79.00 Mn |
| Mar 31, 2025 | -61,000.00 |
| Mar 31, 2025 | -61,000.00 |
| Dec 31, 2024 | -170.54 Mn |
| Dec 31, 2024 | -170.54 Mn |
| Sep 30, 2024 | 42.74 Mn |
| Sep 30, 2024 | 42.74 Mn |
| Jun 30, 2024 | -120.52 Mn |
| Jun 30, 2024 | -120.52 Mn |
| Mar 31, 2024 | -104.96 Mn |
| Mar 31, 2024 | -104.96 Mn |
| Dec 31, 2023 | -35.27 Mn |
| Dec 31, 2023 | -35.27 Mn |
| Sep 30, 2023 | -97.63 Mn |
| Sep 30, 2023 | -97.63 Mn |
| Jun 30, 2023 | 6.76 Mn |
| Jun 30, 2023 | 6.76 Mn |
| Mar 31, 2023 | 17.75 Mn |
| Mar 31, 2023 | 17.75 Mn |
| Dec 31, 2022 | 14.00 Mn |
| Dec 31, 2022 | 14.00 Mn |
| Sep 30, 2022 | 16.50 Mn |
| Sep 30, 2022 | 16.50 Mn |
| Jun 30, 2022 | 750,000.00 |
| Jun 30, 2022 | 750,000.00 |
| Mar 31, 2022 | 25.76 Mn |
| Mar 31, 2022 | 25.76 Mn |
| Dec 31, 2021 | 9.66 Mn |
| Dec 31, 2021 | 9.66 Mn |
| Sep 30, 2021 | 5.78 Mn |
| Sep 30, 2021 | 5.78 Mn |
| Jun 30, 2021 | -47.36 Mn |
| Jun 30, 2021 | -47.36 Mn |
| Mar 31, 2021 | 9.30 Mn |
| Mar 31, 2021 | 9.30 Mn |
| Dec 31, 2020 | 28.62 Mn |
| Dec 31, 2020 | 28.62 Mn |
| Sep 30, 2020 | 5.78 Mn |
| Sep 30, 2020 | 5.78 Mn |
| Jun 30, 2020 | -56.76 Mn |
| Jun 30, 2020 | -56.76 Mn |
| Mar 31, 2020 | 14.75 Mn |
| Mar 31, 2020 | 14.75 Mn |
| Dec 31, 2019 | 10.33 Mn |
| Dec 31, 2019 | 10.33 Mn |
| Sep 30, 2019 | 16.01 Mn |
| Sep 30, 2019 | 16.01 Mn |
| Jun 30, 2019 | -42.01 Mn |
| Jun 30, 2019 | -42.01 Mn |
| Mar 31, 2019 | 13.94 Mn |
| Mar 31, 2019 | 13.94 Mn |
| Dec 31, 2018 | -2.13 Mn |
| Dec 31, 2018 | -2.13 Mn |
| Sep 30, 2018 | 1.40 Mn |
| Sep 30, 2018 | 1.40 Mn |
| Jun 30, 2018 | -19.20 Mn |
| Jun 30, 2018 | -19.20 Mn |
| Mar 31, 2018 | 4.70 Mn |
| Mar 31, 2018 | 4.70 Mn |
| Dec 31, 2017 | 4.84 Mn |
| Dec 31, 2017 | 4.84 Mn |
| Sep 30, 2017 | -6.29 Mn |
| Sep 30, 2017 | -6.29 Mn |
| Jun 30, 2017 | 4.52 Mn |
| Jun 30, 2017 | 4.52 Mn |
| Mar 31, 2017 | -25.61 Mn |
| Mar 31, 2017 | -25.61 Mn |
| Dec 31, 2016 | 2.56 Mn |
| Dec 31, 2016 | 2.56 Mn |
| Sep 30, 2016 | -15.30 Mn |
| Sep 30, 2016 | -15.30 Mn |
| Jun 30, 2016 | 1.85 Mn |
| Jun 30, 2016 | 1.85 Mn |
| Mar 31, 2016 | -1.19 Mn |
| Mar 31, 2016 | -1.19 Mn |
| Dec 31, 2015 | -510,000.00 |
| Dec 31, 2015 | -510,000.00 |
| Sep 30, 2015 | -3.46 Mn |
| Sep 30, 2015 | -3.46 Mn |
| Jun 30, 2015 | -24,000.00 |
| Jun 30, 2015 | -24,000.00 |
| Mar 31, 2015 | -20,000.00 |
| Mar 31, 2015 | -20,000.00 |