Spyre Therapeutics (SYRE) Common Equity (2015 - 2026)

Spyre Therapeutics posted quarterly Common Equity of $670.8 million for Q1 2026, up 39.0% year-on-year from $482.6 million in Q1 2025, and down 6.21% on a QoQ basis from $715.2 million in Q4 2025.

Spyre Therapeutics (SYRE) has 12 years of Common Equity data on file, last reported at $670.8 million in Q1 2026.

  • For the quarter ending Q1 2026, Common Equity rose 39.0% year-over-year to $670.8 million; the trailing twelve-month figure through Mar 2026 stood at $670.8 million (up 39.0% YoY), and the FY2025 full-year result was $715.2 million, up 38.13% from the prior year.
  • Common Equity for Q1 2026 stood at $670.8 million, down from $715.2 million in the prior quarter.
  • Across five years, Common Equity topped out at $715.2 million in Q4 2025 and bottomed at -$245.4 million in Q3 2023.
  • The 5-year median for Common Equity is $184.0 million (2023), against an average of $245.9 million.
  • The widest annual swing landed in 2023, when Common Equity slumped 463.26%; it then surged 352.48% in 2024.
  • A 5-year view of Common Equity shows it stood at $50.3 million in 2022, then jumped by 265.8% to $184.0 million in 2023, then jumped by 181.39% to $517.8 million in 2024, then surged by 38.13% to $715.2 million in 2025, then retreated by 6.21% to $670.8 million in 2026.
  • The last three Common Equity figures came in at $670.8 million (Q1 2026), $715.2 million (Q4 2025), and $455.1 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Common Equity (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - -1.42 Mn
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - 35.63 Mn
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn 1.00 Bn
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - 14.38 Mn
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 19.36 Bn
7 Evaxion A 62.56 Bn 62.54 Bn - 13.21 Mn
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 31.42 Bn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 1.08 Bn
10 Spyre Therapeutics 5.55 Bn 5.55 Bn - 670.81 Mn

Historic Data

Download Data 🔒
DateValue
Mar 31, 2026 670.81 Mn
Dec 31, 2025 715.24 Mn
Sep 30, 2025 455.10 Mn
Jun 30, 2025 455.77 Mn
Mar 31, 2025 482.61 Mn
Dec 31, 2024 517.80 Mn
Sep 30, 2024 327.39 Mn
Jun 30, 2024 374.39 Mn
Mar 31, 2024 152.27 Mn
Dec 31, 2023 184.02 Mn
Sep 30, 2023 -245.40 Mn
Jun 30, 2023 -207.37 Mn
Mar 31, 2023 33.65 Mn
Dec 31, 2022 50.31 Mn
Sep 30, 2022 67.56 Mn
Jun 30, 2022 84.16 Mn
Mar 31, 2022 61.66 Mn
Dec 31, 2021 83.94 Mn
Sep 30, 2021 102.08 Mn
Jun 30, 2021 119.02 Mn
Mar 31, 2021 123.76 Mn
Dec 31, 2020 139.83 Mn
Sep 30, 2020 136.27 Mn
Jun 30, 2020 152.26 Mn
Mar 31, 2020 42.81 Mn
Dec 31, 2019 60.08 Mn
Sep 30, 2019 79.80 Mn
Jun 30, 2019 99.62 Mn
Mar 31, 2019 116.29 Mn
Dec 31, 2018 67.43 Mn
Sep 30, 2018 63.68 Mn
Jun 30, 2018 73.45 Mn
Mar 31, 2018 43.92 Mn
Dec 31, 2017 50.34 Mn
Sep 30, 2017 55.51 Mn
Jun 30, 2017 62.60 Mn
Mar 31, 2017 57.18 Mn
Dec 31, 2016 62.97 Mn
Sep 30, 2016 68.20 Mn
Jun 30, 2016 73.92 Mn
Mar 31, 2016 -26.61 Mn
Dec 31, 2015 -22.21 Mn