Spyre Therapeutics (SYRE) Change in Acquisitions & Divestments (2016 - 2026)
Spyre Therapeutics posted quarterly Change in Acquisitions & Divestments of $107.7 million for Q1 2026, up 50.94% year-on-year from $71.4 million in Q1 2025, and up 14.26% on a QoQ basis from $94.3 million in Q4 2025.
Spyre Therapeutics (SYRE) has 11 years of Change in Acquisitions & Divestments data on file, last reported at $107.7 million in Q1 2026.
- For the quarter ending Q1 2026, Change in Acquisitions & Divestments rose 50.94% year-over-year to $107.7 million; the trailing twelve-month figure through Mar 2026 stood at $408.1 million (up 51.37% YoY), and the FY2025 full-year result was $371.7 million, up 51.13% from the prior year.
- Change in Acquisitions & Divestments for Q1 2026 stood at $107.7 million, up from $94.3 million in the prior quarter.
- Across five years, Change in Acquisitions & Divestments topped out at $107.7 million in Q1 2026 and bottomed at $3.2 million in Q2 2023.
- The 5-year median for Change in Acquisitions & Divestments is $52.8 million (2024), against an average of $53.9 million.
- The widest annual swing landed in 2023, when Change in Acquisitions & Divestments plunged 87.0%; it then soared 1680.8% in 2024.
- A 5-year view of Change in Acquisitions & Divestments shows it stood at $18.5 million in 2022, then grew by 2.16% to $18.9 million in 2023, then surged by 230.94% to $62.5 million in 2024, then surged by 50.76% to $94.3 million in 2025, then advanced by 14.26% to $107.7 million in 2026.
- The last three Change in Acquisitions & Divestments figures came in at $107.7 million (Q1 2026), $94.3 million (Q4 2025), and $99.2 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) |
|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn |
| 10 | Spyre Therapeutics | 5.55 Bn | 5.55 Bn | - |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 107.75 Mn |
| Mar 31, 2026 | 107.75 Mn |
| Dec 31, 2025 | 94.30 Mn |
| Dec 31, 2025 | 94.30 Mn |
| Sep 30, 2025 | 99.19 Mn |
| Sep 30, 2025 | 99.19 Mn |
| Jun 30, 2025 | 106.87 Mn |
| Jun 30, 2025 | 106.87 Mn |
| Mar 31, 2025 | 71.38 Mn |
| Mar 31, 2025 | 71.38 Mn |
| Dec 31, 2024 | 62.55 Mn |
| Dec 31, 2024 | 62.55 Mn |
| Sep 30, 2024 | 77.79 Mn |
| Sep 30, 2024 | 77.79 Mn |
| Jun 30, 2024 | 57.88 Mn |
| Jun 30, 2024 | 57.88 Mn |
| Mar 31, 2024 | 47.75 Mn |
| Mar 31, 2024 | 47.75 Mn |
| Dec 31, 2023 | 18.90 Mn |
| Dec 31, 2023 | 18.90 Mn |
| Jun 30, 2023 | 3.25 Mn |
| Jun 30, 2023 | 3.25 Mn |
| Mar 31, 2023 | 17.75 Mn |
| Mar 31, 2023 | 17.75 Mn |
| Dec 31, 2022 | 18.50 Mn |
| Dec 31, 2022 | 18.50 Mn |
| Sep 30, 2022 | 23.75 Mn |
| Sep 30, 2022 | 23.75 Mn |
| Jun 30, 2022 | 25.00 Mn |
| Jun 30, 2022 | 25.00 Mn |
| Mar 31, 2022 | 29.30 Mn |
| Mar 31, 2022 | 29.30 Mn |
| Dec 31, 2021 | 22.91 Mn |
| Dec 31, 2021 | 22.91 Mn |
| Sep 30, 2021 | 32.12 Mn |
| Sep 30, 2021 | 32.12 Mn |
| Jun 30, 2021 | 22.00 Mn |
| Jun 30, 2021 | 22.00 Mn |
| Mar 31, 2021 | 34.00 Mn |
| Mar 31, 2021 | 34.00 Mn |
| Dec 31, 2020 | 60.62 Mn |
| Dec 31, 2020 | 60.62 Mn |
| Sep 30, 2020 | 28.85 Mn |
| Sep 30, 2020 | 28.85 Mn |
| Jun 30, 2020 | 16.06 Mn |
| Jun 30, 2020 | 16.06 Mn |
| Mar 31, 2020 | 20.14 Mn |
| Mar 31, 2020 | 20.14 Mn |
| Dec 31, 2019 | 15.75 Mn |
| Dec 31, 2019 | 15.75 Mn |
| Sep 30, 2019 | 25.88 Mn |
| Sep 30, 2019 | 25.88 Mn |
| Jun 30, 2019 | 16.25 Mn |
| Jun 30, 2019 | 16.25 Mn |
| Mar 31, 2019 | 33.80 Mn |
| Mar 31, 2019 | 33.80 Mn |
| Dec 31, 2018 | 24.75 Mn |
| Dec 31, 2018 | 24.75 Mn |
| Sep 30, 2018 | 10.75 Mn |
| Sep 30, 2018 | 10.75 Mn |
| Jun 30, 2018 | 7.09 Mn |
| Jun 30, 2018 | 7.09 Mn |
| Mar 31, 2018 | 4.79 Mn |
| Mar 31, 2018 | 4.79 Mn |
| Dec 31, 2017 | 7.04 Mn |
| Dec 31, 2017 | 7.04 Mn |
| Sep 30, 2017 | 18.16 Mn |
| Sep 30, 2017 | 18.16 Mn |
| Jun 30, 2017 | 9.57 Mn |
| Jun 30, 2017 | 9.57 Mn |
| Mar 31, 2017 | 7.44 Mn |
| Mar 31, 2017 | 7.44 Mn |
| Dec 31, 2016 | 2.68 Mn |
| Dec 31, 2016 | 2.68 Mn |
| Sep 30, 2016 | 2.00 Mn |
| Sep 30, 2016 | 2.00 Mn |
| Jun 30, 2016 | 2.02 Mn |
| Jun 30, 2016 | 2.02 Mn |
| Mar 31, 2016 | 1.75 Mn |
| Mar 31, 2016 | 1.75 Mn |