Spyre Therapeutics (SYRE) Change in Acquisitions & Divestments (2016 - 2026)

Spyre Therapeutics (SYRE) reported Change in Acquisitions & Divestments of $107.7 million for Q1 2026, up 50.94% on a YoY basis from $71.4 million in Q1 2025, and up 14.26% quarter-over-quarter from $94.3 million in Q4 2025.

Spyre Therapeutics (SYRE) Change in Acquisitions & Divestments (2016 - 2026) Analysis & Trends

Spyre Therapeutics has reported Change in Acquisitions & Divestments for 11 years, with the latest figure at $107.7 million in Q1 2026.

  • For the quarter ending Q1 2026, Change in Acquisitions & Divestments rose 50.94% year-over-year to $107.7 million; the trailing twelve-month figure through Mar 2026 stood at $408.1 million (up 51.37% YoY), and the FY2025 full-year result was $371.7 million, up 51.13% from the prior year.
  • Change in Acquisitions & Divestments for Q1 2026 stood at $107.7 million, up from $94.3 million in the prior quarter.
  • The five-year high for Change in Acquisitions & Divestments was $107.7 million in Q1 2026, with the low at $3.2 million in Q2 2023.
  • Historically, Change in Acquisitions & Divestments has averaged $53.9 million across 5 years, with a median of $52.8 million in 2024.
  • Annual changes were most pronounced in 2023 — Change in Acquisitions & Divestments slumped 87.0% — and 2024, when it soared 1680.8%.
  • Spyre Therapeutics' Change in Acquisitions & Divestments stood at $18.5 million in 2022, then climbed by 2.16% to $18.9 million in 2023, then jumped by 230.94% to $62.5 million in 2024, then jumped by 50.76% to $94.3 million in 2025, then gained by 14.26% to $107.7 million in 2026.
  • The last three Change in Acquisitions & Divestments figures came in at $107.7 million (Q1 2026), $94.3 million (Q4 2025), and $99.2 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn -
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn -
7 Psyence Biomedical 212.16 Bn 212.16 Bn -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn
9 Abivax 91.96 Bn 91.96 Bn -
10 Spyre Therapeutics 6.95 Bn 6.95 Bn -

Historic Data

Download Data
DateValue
Mar 31, 2026 107.75 Mn
Mar 31, 2026 107.75 Mn
Dec 31, 2025 94.30 Mn
Dec 31, 2025 94.30 Mn
Sep 30, 2025 99.19 Mn
Sep 30, 2025 99.19 Mn
Jun 30, 2025 106.87 Mn
Jun 30, 2025 106.87 Mn
Mar 31, 2025 71.38 Mn
Mar 31, 2025 71.38 Mn
Dec 31, 2024 62.55 Mn
Dec 31, 2024 62.55 Mn
Sep 30, 2024 77.79 Mn
Sep 30, 2024 77.79 Mn
Jun 30, 2024 57.88 Mn
Jun 30, 2024 57.88 Mn
Mar 31, 2024 47.75 Mn
Mar 31, 2024 47.75 Mn
Dec 31, 2023 18.90 Mn
Dec 31, 2023 18.90 Mn