Spyre Therapeutics (SYRE) Change in Acquisitions & Divestments (2016 - 2026)
Spyre Therapeutics (SYRE) reported Change in Acquisitions & Divestments of $107.7 million for Q1 2026, up 50.94% on a YoY basis from $71.4 million in Q1 2025, and up 14.26% quarter-over-quarter from $94.3 million in Q4 2025.
Spyre Therapeutics (SYRE) Change in Acquisitions & Divestments (2016 - 2026) Analysis & Trends
Spyre Therapeutics has reported Change in Acquisitions & Divestments for 11 years, with the latest figure at $107.7 million in Q1 2026.
- For the quarter ending Q1 2026, Change in Acquisitions & Divestments rose 50.94% year-over-year to $107.7 million; the trailing twelve-month figure through Mar 2026 stood at $408.1 million (up 51.37% YoY), and the FY2025 full-year result was $371.7 million, up 51.13% from the prior year.
- Change in Acquisitions & Divestments for Q1 2026 stood at $107.7 million, up from $94.3 million in the prior quarter.
- The five-year high for Change in Acquisitions & Divestments was $107.7 million in Q1 2026, with the low at $3.2 million in Q2 2023.
- Historically, Change in Acquisitions & Divestments has averaged $53.9 million across 5 years, with a median of $52.8 million in 2024.
- Annual changes were most pronounced in 2023 — Change in Acquisitions & Divestments slumped 87.0% — and 2024, when it soared 1680.8%.
- Spyre Therapeutics' Change in Acquisitions & Divestments stood at $18.5 million in 2022, then climbed by 2.16% to $18.9 million in 2023, then jumped by 230.94% to $62.5 million in 2024, then jumped by 50.76% to $94.3 million in 2025, then gained by 14.26% to $107.7 million in 2026.
- The last three Change in Acquisitions & Divestments figures came in at $107.7 million (Q1 2026), $94.3 million (Q4 2025), and $99.2 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) |
|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - |
| 10 | Spyre Therapeutics | 6.95 Bn | 6.95 Bn | - |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 107.75 Mn |
| Mar 31, 2026 | 107.75 Mn |
| Dec 31, 2025 | 94.30 Mn |
| Dec 31, 2025 | 94.30 Mn |
| Sep 30, 2025 | 99.19 Mn |
| Sep 30, 2025 | 99.19 Mn |
| Jun 30, 2025 | 106.87 Mn |
| Jun 30, 2025 | 106.87 Mn |
| Mar 31, 2025 | 71.38 Mn |
| Mar 31, 2025 | 71.38 Mn |
| Dec 31, 2024 | 62.55 Mn |
| Dec 31, 2024 | 62.55 Mn |
| Sep 30, 2024 | 77.79 Mn |
| Sep 30, 2024 | 77.79 Mn |
| Jun 30, 2024 | 57.88 Mn |
| Jun 30, 2024 | 57.88 Mn |
| Mar 31, 2024 | 47.75 Mn |
| Mar 31, 2024 | 47.75 Mn |
| Dec 31, 2023 | 18.90 Mn |
| Dec 31, 2023 | 18.90 Mn |