Spyre Therapeutics SYRE
NASDAQ SYRE
$86.55 -0.70 (-0.80%)
As of: Sep 4, 2026 · 12:50 PM EDT

Spyre Therapeutics (SYRE) Shares Outstanding (2015 - 2026)

Spyre Therapeutics' (SYRE) quarterly Shares Outstanding (Entity) came in at $78.8 million in Q1 2026, up 30.8% YoY from $60.3 million in Q1 2025, and up 23.08% on a QoQ basis from $64.1 million in Q4 2025.

Analysis

Spyre Therapeutics (SYRE) Shares Outstanding (2015 - 2026) Analysis & Trends

Spyre Therapeutics (SYRE) has 12 years of Shares Outstanding (Entity) data on file, last reported at $78.8 million in Q1 2026.

  • Quarterly Shares Outstanding (Entity) rose 30.8% year-over-year to $78.8 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was $78.8 million (up 30.8% YoY) and the FY2025 annual result came in at $64.1 million, up 36.21% from the prior year.
  • Shares Outstanding (Entity) climbed to $78.8 million in Q1 2026, from $64.1 million in the prior quarter.
  • In the past five years, Shares Outstanding (Entity) ranged from a high of $78.8 million in Q1 2026 to a low of $2.6 million in Q1 2022.
  • A 5-year average of $31.8 million and a median of $36.6 million in 2024 frame the typical range for Shares Outstanding (Entity).
  • Annual changes were most pronounced in 2023 — Shares Outstanding (Entity) retreated 1.47% — and 2024, when it soared 1467.34%.
  • Tracing SYRE's Shares Outstanding (Entity) over 5 years: stood at $3.4 million in 2022, then surged by 104.59% to $6.9 million in 2023, then jumped by 581.85% to $47.0 million in 2024, then soared by 36.21% to $64.1 million in 2025, then advanced by 23.08% to $78.8 million in 2026.
  • The last three Shares Outstanding (Entity) figures came in at $78.8 million (Q1 2026), $64.1 million (Q4 2025), and $60.5 million (Q3 2025), per Business Quant data.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Shares Outstanding (Qtr)
1 Vertex Pharmaceuticals 139.62 Bn 131.77 Bn 2.84 Bn 253.70 Mn
2 Regeneron Pharmaceuticals 85.73 Bn 77.73 Bn 3.93 Bn 102.80 Mn
3 Argenx Se 63.53 Bn 58.35 Bn 1.37 Bn 61.30 Mn
4 Moderna 58.23 Bn 53.09 Bn 52.00 Mn 398.00 Mn
5 Revolution Medicines 44.05 Bn 44.05 Bn - 210.89 Mn
6 BeOne Medicines 40.03 Bn 34.93 Bn 1.53 Bn 111.58 Mn
7 Alnylam Pharmaceuticals 35.50 Bn 32.19 Bn 992.69 Mn 133.61 Mn
8 Royalty Pharma 28.52 Bn 27.68 Bn - 445.06 Mn
9 Insmed 27.46 Bn 26.30 Bn 358.27 Mn 217.35 Mn
10 Spyre Therapeutics 7.35 Bn 7.35 Bn - 84.73 Mn
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 84.73 Mn
Mar 31, 2026 78.55 Mn
Dec 31, 2025 64.42 Mn
Sep 30, 2025 60.78 Mn
Jun 30, 2025 60.70 Mn
Mar 31, 2025 60.63 Mn
Dec 31, 2024 47.49 Mn
Sep 30, 2024 51.25 Mn
Jun 30, 2024 45.83 Mn
Mar 31, 2024 37.12 Mn
Dec 31, 2023 7.34 Mn
Sep 30, 2023 4.29 Mn
Jun 30, 2023 3.82 Mn
Mar 31, 2023 3.77 Mn
Dec 31, 2022 3.37 Mn
Sep 30, 2022 3.77 Mn
Jun 30, 2022 3.29 Mn
Mar 31, 2022 2.64 Mn
Dec 31, 2021 2.63 Mn
Sep 30, 2021 2.63 Mn