The institutional landscape for Spyre Therapeutics, Inc. (NASDAQ:SYRE) includes 137 filers as of the latest reporting cycle ending September 2025.
| Owner Name | Date | Shares Held | Change (QoQ) | Change (%) | Value (USD) |
|---|---|---|---|---|---|
| FMR LLC | 30 Sep, 2025 | 9,060,144 | 7,110 | 0.08% | $151,848,013.00 |
| Fairmount Funds Management LLC | 30 Sep, 2025 | 4,018,101 | 0 | 0.00% | $67,343,373.00 |
| BlackRock, Inc. | 30 Sep, 2025 | 3,982,744 | -24,552 | -0.61% | $66,750,788.00 |
| RTW INVESTMENTS, LP | 30 Sep, 2025 | 3,621,996 | 0 | 0.00% | $60,704,653.00 |
| TANG CAPITAL MANAGEMENT LLC | 30 Sep, 2025 | 3,200,000 | 0 | 0.00% | $53,632,000.00 |
| VANGUARD GROUP INC | 30 Sep, 2025 | 3,050,730 | -15,856 | -0.52% | $51,130,235.00 |
| VR Adviser, LLC | 30 Sep, 2025 | 2,685,448 | 0 | 0.00% | $45,008,108.00 |
| BRAIDWELL LP | 30 Sep, 2025 | 2,578,404 | 0 | 0.00% | $43,214,051.00 |
| Capital International Investors | 30 Sep, 2025 | 2,392,541 | 0 | 0.00% | $40,098,987.00 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 30 Sep, 2025 | 2,060,375 | -25,215 | -1.21% | $34,531,885.00 |
| Commodore Capital LP | 30 Sep, 2025 | 1,988,084 | 0 | 0.00% | $33,320,288.00 |
| STATE STREET CORP | 30 Sep, 2025 | 1,785,206 | 189,915 | 11.90% | $29,920,053.00 |
| WELLINGTON MANAGEMENT GROUP LLP | 30 Sep, 2025 | 1,640,312 | 126,834 | 8.38% | $27,491,629.00 |
| Paradigm Biocapital Advisors LP | 30 Sep, 2025 | 1,467,266 | -403,179 | -21.56% | $24,591,378.00 |
| Affinity Asset Advisors, LLC | 30 Sep, 2025 | 1,419,299 | 812,621 | 133.95% | $23,787,451.00 |
| Jefferies Financial Group Inc. | 30 Sep, 2025 | 1,388,854 | 0 | 0.00% | $23,277,193.00 |
| PERCEPTIVE ADVISORS LLC | 30 Sep, 2025 | 1,229,445 | -300,000 | -19.61% | $20,605,498.00 |
| GEODE CAPITAL MANAGEMENT, LLC | 30 Sep, 2025 | 1,225,153 | -2,079 | -0.17% | $20,536,009.00 |
| TCG Crossover Management, LLC | 30 Sep, 2025 | 1,100,582 | 1,100,582 | 0.00% | $18,445,754.00 |
| Pictet Asset Management Holding SA | 30 Sep, 2025 | 1,036,218 | -43,225 | -4.00% | $17,367,014.00 |