Spyre Therapeutics SYRE Institutional Ownership

NASDAQ SYRE

$89.10 +1.85 (+2.12%)

As of: Sep 4, 2026 · 3:59 PM EDT

Institutions by Trading Activity

265 Institutions

Increased 193 72.8%

Unchanged 15 5.7%

Reduced 57 21.5%

Ownership Statistics

13F · as of 30 Jun, 2026

Institutional Ownership

113.85%

▲+5.92 pp QoQ

Shares Held by Institutions

96.46Mn

of 84.73Mn outstanding

▲+30.85% QoQ

Shares Outstanding

84.73Mn

-11.73Mn held outside 13F filers

Institutional Investors

265

filed 13F for Jun 2026

▲+67 vs prior quarter

Net Shares Added (QoQ)

+22.74Mn

accumulated since last quarter

Value of Holdings

$8.42Bn

reported market value

Shares Owned by Institutions

Shares held % of outstanding

Latest —

Average ownership —

Peak ownership —

Shares Purchased/Sold by Institutions

Accumulated Distributed

Latest quarter —

Net over range —

Accumulating quarters —

Ownership Summary

Quarter ending 30 Jun, 2026

Spyre Therapeutics, Inc. (NASDAQ:SYRE) is held by 265 institutional investors per 13F filings through June 2026.

These investors held 113.8% of outstanding shares in June 2026, up from 107.9% in March 2026.
They increased total shares held in Spyre Therapeutics by 30.85% from the prior quarter, while the number of investors in SYRE increased 107.03% year over year.
During the quarter, 193 of these 265 funds increased positions in SYRE, 57 reduced exposure, and 15 held steady.
Institutional investors collectively held 96.46Mn shares in Spyre Therapeutics as of June 2026, up by 22.74Mn shares quarter on quarter, and up 33.2Mn shares year over year.
FMR LLC is the top holder of Spyre Therapeutics as of June 30, 2026, with 13.03Mn shares representing 15.37% of outstanding stock.
Leading buyers of Spyre Therapeutics shares for the quarter ending June 2026 were Jupiter Topco LLC (2.21Mn), Paradigm Biocapital Advisors LP (1.88Mn), VANGUARD PORTFOLIO MANAGEMENT LLC (1.74Mn), ADAGE CAPITAL PARTNERS GP, L.L.C. (1.72Mn), Capital World Investors (1.65Mn).
The largest sales of SYRE for the quarter ending June 2026 came from Commodore Capital LP (1.07Mn), Capital International Investors (790.93K), Venrock Adviser, LLC (700.0K), Remedium Capital Partners, LLC (443.16K), WELLINGTON MANAGEMENT GROUP LLP (243.31K).
Per Business Quant data, the top 10 holders of Spyre Therapeutics for the quarter ending June 2026 are FMR LLC (13.03Mn), BlackRock, Inc. (6.51Mn), PERCEPTIVE ADVISORS LLC (4.32Mn), RTW INVESTMENTS, LP (4.25Mn), Paradigm Biocapital Advisors LP (3.84Mn), VANGUARD CAPITAL MANAGEMENT LLC (3.45Mn), State Street Corp (3.06Mn), Venrock Adviser, LLC (2.99Mn), PRICE T ROWE ASSOCIATES INC /MD/ (2.96Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (2.8Mn).

Form 13F Holdings

265 Institutional Holders

Report period 30 Jun, 2026

Total shares held 96.46Mn

Of outstanding 113.85%

#	Institution	CIK	Shares Held	% of Outstanding	Change (QoQ)	Change (%)	Value (USD)
1	FMR LLC	0000315066	13,026,187	15.37%	▲1,245,163	+10.57%	$1.16Bn
2	BlackRock, Inc.	0002012383	6,506,605	7.68%	▲985,384	+17.85%	$577.66Mn
3	PERCEPTIVE ADVISORS LLC	0001224962	4,319,496	5.10%	▲536,271	+14.17%	$383.48Mn
4	RTW INVESTMENTS, LP	0001493215	4,251,996	5.02%	▲80,000	+1.92%	$377.49Mn
5	Paradigm Biocapital Advisors LP	0001855655	3,840,778	4.53%	▲1,883,512	+96.23%	$340.98Mn
6	VANGUARD CAPITAL MANAGEMENT LLC	0002100119	3,448,681	4.07%	▲391,280	+12.80%	$306.17Mn
7	State Street Corp	0000093751	3,057,416	3.61%	▲450,385	+17.28%	$271.44Mn
8	Venrock Adviser, LLC	0001615982	2,985,448	3.52%	▼700,000	-18.99%	$265.05Mn
9	PRICE T ROWE ASSOCIATES INC /MD/	0000080255	2,960,855	3.49%	▲1,362,125	+85.20%	$262.87K
10	DRIEHAUS CAPITAL MANAGEMENT LLC	0000938206	2,799,166	3.30%	▲8,381	+0.30%	$248.51Mn
11	GEODE CAPITAL MANAGEMENT, LLC	0001214717	2,562,265	3.02%	▲841,353	+48.89%	$239.26Mn
12	VANGUARD PORTFOLIO MANAGEMENT LLC	0002100121	2,330,098	2.75%	▲1,744,968	+298.22%	$206.87Mn
13	Capital World Investors	0001422849	2,315,553	2.73%	▲1,648,989	+247.39%	$205.57Mn
14	Jupiter Topco LLC	0002146052	2,206,936	2.60%	▲2,206,936	0.00%	$195.88Mn
15	TCG Crossover Management, LLC	0001839948	1,900,582	2.24%	0	0.00%	$168.73Mn
16	TANG CAPITAL MANAGEMENT LLC	0001232621	1,892,200	2.23%	0	0.00%	$167.99Mn
17	Bank Of America Corp /De/	0000070858	1,777,854	2.10%	▲549,761	+44.77%	$157.84Mn
18	ADAGE CAPITAL PARTNERS GP, L.L.C.	0001165408	1,722,300	2.03%	▲1,722,300	0.00%	$152.91Mn
19	WELLINGTON MANAGEMENT GROUP LLP	0000902219	1,581,505	1.87%	▼243,306	-13.33%	$140.41Mn
20	Goldman Sachs Group Inc	0000886982	1,478,059	1.74%	▲1,208,121	+447.56%	$131.22Mn

Showing 1 to 20 of 265 holders