Spyre Therapeutics, Inc. (SYRE) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

60,414,223Shares Outstanding
79,284,443Shares held by institutions
$7,927,651,286Value of institutional holdings
131.23%Institutional ownership %
27.82%Shares Changed QoQ
151No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Spyre Therapeutics, Inc. (NASDAQ:SYRE) has 151 institutional investors that have filed 13F reports for the period ending December 2025.

196 Institutional Holders

79,284,443 Total Shares Held
Download Data
Owner Name Date Shares Held Change (QoQ) Change (%) Value (USD)
FMR LLC 31 Mar, 2026 11,781,024 142,205 1.22% $594,234,851.00
BlackRock, Inc. 31 Mar, 2026 5,521,221 -880 -0.02% $278,490,385.00
RTW INVESTMENTS, LP 31 Mar, 2026 4,171,996 0 0.00% $210,435,478.00
Fairmount Funds Management LLC 31 Mar, 2026 4,018,101 0 0.00% $202,673,014.00
PERCEPTIVE ADVISORS LLC 31 Mar, 2026 3,783,225 714,000 23.26% $190,825,869.00
Venrock Adviser, LLC 31 Mar, 2026 3,685,448 0 0.00% $185,893,997.00
Janus Henderson Group Plc 31 Mar, 2026 3,312,328 1,483,319 81.10% $167,173,194.00
VANGUARD CAPITAL MANAGEMENT LLC 31 Mar, 2026 3,057,401 3,057,401 0.00% $154,215,306.00
DRIEHAUS CAPITAL MANAGEMENT LLC 31 Mar, 2026 2,790,785 -91,635 -3.18% $140,767,195.00
State Street Corp 31 Mar, 2026 2,607,031 344,192 15.21% $131,498,644.00
Paradigm Biocapital Advisors LP 31 Mar, 2026 1,957,266 490,000 33.40% $98,724,497.00
Commodore Capital LP 31 Mar, 2026 1,912,380 -475,865 -19.93% $96,460,447.00
Remedium Capital Partners, LLC 31 Mar, 2026 1,907,327 451,096 30.98% $96,205,574.00
TCG Crossover Management, LLC 31 Mar, 2026 1,900,582 0 0.00% $95,865,356.00
TANG CAPITAL MANAGEMENT LLC 31 Mar, 2026 1,892,200 0 0.00% $95,442,568.00
WELLINGTON MANAGEMENT GROUP LLP 31 Mar, 2026 1,824,811 275,527 17.78% $92,043,467.00
Capital International Investors 31 Mar, 2026 1,746,129 -1,746,412 -50.00% $88,074,747.00
GEODE CAPITAL MANAGEMENT, LLC 31 Mar, 2026 1,720,912 61,772 3.72% $86,819,367.00
RA CAPITAL MANAGEMENT, L.P. 31 Mar, 2026 1,621,620 0 0.00% $81,794,513.00
PRICE T ROWE ASSOCIATES INC /MD/ 31 Mar, 2026 1,598,730 1,598,730 0.00% $80,641.00