Spyre Therapeutics, Inc. (SYRE) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

0Shares Outstanding

18,771,830Shares held by institutions

$852,710,378Value of institutional holdings

104.85%Institutional ownership %

-2.25%Shares Changed QoQ

128No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Spyre Therapeutics, Inc. (NASDAQ:SYRE) has 151 institutional investors with active 13F positions as of December 2025.

These investors collectively held 131.2% of Spyre Therapeutics's outstanding shares in December 2025, up from 107.5% in September 2025.
They increased total shares held in Spyre Therapeutics by 27.82% from the prior quarter, while the number of investors in SYRE increased 16.15% year over year.
Of these 151 funds, 104 grew their exposure to Spyre Therapeutics, 27 cut back, and 20 maintained positions.
Combined, these investors held 79.28Mn shares in SYRE for December 2025, up by 17.26Mn shares quarter on quarter, and up 17.86Mn shares year over year.
As of December 31, 2025, the biggest holder of Spyre Therapeutics is FMR LLC at 11.64Mn shares, representing 19.27% of shares outstanding.
The most significant purchases of SYRE for the quarter ending December 2025 came from FMR LLC (2.58Mn), PERCEPTIVE ADVISORS LLC (1.84Mn), Janus Henderson Group Plc (1.82Mn), RA CAPITAL MANAGEMENT, L.P. (1.62Mn), BlackRock, Inc. (1.54Mn).
Top sellers of SYRE stock for the quarter ending December 2025 included TANG CAPITAL MANAGEMENT LLC (1.31Mn), BRAIDWELL LP (943.79K), Jpmorgan Chase & Co (489.02K), MILLENNIUM MANAGEMENT LLC (332.0K), BNP PARIBAS FINANCIAL MARKETS (304.06K).
Spyre Therapeutics's 10 largest shareholders as of December 2025 include FMR LLC (11.64Mn), BlackRock, Inc. (5.52Mn), RTW INVESTMENTS, LP (4.17Mn), VANGUARD GROUP INC (4.04Mn), Fairmount Funds Management LLC (4.02Mn), VR Adviser, LLC (3.69Mn), Capital International Investors (3.49Mn), PERCEPTIVE ADVISORS LLC (3.07Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (2.88Mn), Commodore Capital LP (2.39Mn) per Business Quant data.

151 Institutional Holders

18,771,830 Total Shares Held

Rows:

Download Data

Owner Name	Date	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	1,539,357	38.65%	$0.00
FMR LLC	31 Dec, 2025	2,578,675	28.46%	$0.00
Fairmount Funds Management LLC	31 Dec, 2025	0	0.00%	$0.00
Barclays Plc	31 Dec, 2025	-91,273	-33.34%	$0.00
RTW INVESTMENTS, LP	31 Dec, 2025	550,000	15.18%	$0.00
VR Adviser, LLC	31 Dec, 2025	1,000,000	37.24%	$0.00
Rockefeller Capital Management L.P.	31 Dec, 2025	697	173.82%	$0.00
VANGUARD GROUP INC	31 Dec, 2025	984,344	32.27%	$0.00
Commodore Capital LP	31 Dec, 2025	400,161	20.13%	$0.00
Capital International Investors	31 Dec, 2025	1,100,000	45.98%	$0.00
TCG Crossover Management, LLC	31 Dec, 2025	800,000	72.69%	$0.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	1,839,780	149.64%	$0.00
BRAIDWELL LP	31 Dec, 2025	-943,789	-36.60%	$0.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	822,045	39.90%	$0.00
Paradigm Biocapital Advisors LP	31 Dec, 2025	0	0.00%	$0.00
State Street Corp	31 Dec, 2025	477,633	26.76%	$0.00
Remedium Capital Partners, LLC	31 Dec, 2025	1,456,231	0.00%	$0.00
TANG CAPITAL MANAGEMENT LLC	31 Dec, 2025	-1,307,800	-40.87%	$0.00
Affinity Asset Advisors, LLC	31 Dec, 2025	13,292	0.94%	$0.00
Janus Henderson Group Plc	31 Dec, 2025	1,816,009	13,969.30%	$0.00

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