Spyre Therapeutics, Inc. (SYRE) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

2,629,936Shares Outstanding

12,568,850Shares held by institutions

$451,850,158Value of institutional holdings

1,515.72%Institutional ownership %

-1.04%Shares Changed QoQ

85No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

A total of 150 institutions have reported a stake in Spyre Therapeutics, Inc. (NASDAQ:SYRE) as of December 2025, according to recent 13F filings with the SEC.

These investors collectively held 106.5% of the company's total shares outstanding in December 2025, up from 86.4% in September 2025.
Quarterly data indicates a 29.33% shift in institutional share volume, and the annual owner count reflects an increase of 15.38%.
During the quarter, 104 institutions bought more Spyre Therapeutics shares, 25 sold shares, and 21 of the 150 total investors held their position steady.
Collectively, institutional investors increased their stake in Spyre Therapeutics to 79.39Mn shares as of December 2025, a change that is up by 18.01Mn shares quarter on quarter and up 19.58Mn shares year over year.
The top institutional stake in Spyre Therapeutics as of December 31, 2025 belongs to FMR LLC, which owns 11.64Mn shares, or 15.61% of the company.
Among the most significant buyers of Spyre Therapeutics during December 2025 were FMR LLC (2.58Mn), PERCEPTIVE ADVISORS LLC (1.84Mn), JANUS HENDERSON GROUP PLC (1.82Mn), RA CAPITAL MANAGEMENT, L.P. (1.62Mn), BlackRock, Inc. (1.54Mn).
Leading sellers of Spyre Therapeutics stock in December 2025 included TANG CAPITAL MANAGEMENT LLC (1.31Mn), BRAIDWELL LP (943.79K), MILLENNIUM MANAGEMENT LLC (332.00K), BNP PARIBAS FINANCIAL MARKETS (304.06K), JPMORGAN CHASE & CO (213.03K).
The top 10 institutional holders of Spyre Therapeutics for the quarter ending December 2025 included FMR LLC (11.64Mn), BlackRock, Inc. (5.52Mn), RTW INVESTMENTS, LP (4.17Mn), VANGUARD GROUP INC (4.04Mn), Fairmount Funds Management LLC (4.02Mn), VR Adviser, LLC (3.69Mn), Capital International Investors (3.49Mn), PERCEPTIVE ADVISORS LLC (3.07Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (2.88Mn), Commodore Capital LP (2.39Mn).

150 Institutional Holders

12,568,850 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
FMR LLC	31 Dec, 2025	11,638,819	2,578,675	28.46%	$381,287,711.00
BlackRock, Inc.	31 Dec, 2025	5,522,101	1,539,357	38.65%	$180,904,030.00
RTW INVESTMENTS, LP	31 Dec, 2025	4,171,996	550,000	15.18%	$136,674,589.00
VANGUARD GROUP INC	31 Dec, 2025	4,035,074	984,344	32.27%	$132,189,024.00
Fairmount Funds Management LLC	31 Dec, 2025	4,018,101	0	0.00%	$131,632,989.00
VR Adviser, LLC	31 Dec, 2025	3,685,448	1,000,000	37.24%	$120,735,276.00
Capital International Investors	31 Dec, 2025	3,492,541	1,100,000	45.98%	$114,415,643.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	3,069,225	1,839,780	149.64%	$100,547,811.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	2,882,420	822,045	39.90%	$94,428,079.00
Commodore Capital LP	31 Dec, 2025	2,388,245	400,161	20.13%	$78,238,906.00
STATE STREET CORP	31 Dec, 2025	2,262,839	477,633	26.76%	$74,130,606.00
TCG Crossover Management, LLC	31 Dec, 2025	1,900,582	800,000	72.69%	$62,263,066.00
TANG CAPITAL MANAGEMENT LLC	31 Dec, 2025	1,892,200	-1,307,800	-40.87%	$61,988,472.00
JANUS HENDERSON GROUP PLC	31 Dec, 2025	1,829,009	1,816,009	13,969.30%	$59,918,335.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,659,140	433,987	35.42%	$54,362,088.00
BRAIDWELL LP	31 Dec, 2025	1,634,615	-943,789	-36.60%	$53,549,987.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	1,621,620	1,621,620	0.00%	$53,124,271.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	1,549,284	-91,028	-5.55%	$50,754,544.00
Paradigm Biocapital Advisors LP	31 Dec, 2025	1,467,266	0	0.00%	$48,067,634.00
Remedium Capital Partners, LLC	31 Dec, 2025	1,456,231	1,456,231	0.00%	$47,706.00

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