Spyre Therapeutics (SYRE) Research & Development (2015 - 2026)
Spyre Therapeutics (SYRE) reported Research & Development of $60.4 million for Q1 2026, up 45.14% on a YoY basis from $41.6 million in Q1 2025, and up 35.34% quarter-over-quarter from $44.6 million in Q4 2025.
Spyre Therapeutics (SYRE) Research & Development (2015 - 2026) Analysis & Trends
Spyre Therapeutics has reported Research & Development for 12 years, with the latest figure at $60.4 million in Q1 2026.
- For the quarter ending Q1 2026, Research & Development rose 45.14% year-over-year to $60.4 million; the trailing twelve-month figure through Mar 2026 stood at $190.4 million (up 12.36% YoY), and the FY2025 full-year result was $171.7 million, up 5.44% from the prior year.
- Research & Development for Q1 2026 stood at $60.4 million, up from $44.6 million in the prior quarter.
- The five-year high for Research & Development was $60.4 million in Q1 2026, with the low at $12.0 million in Q3 2022.
- Historically, Research & Development has averaged $31.9 million across 5 years, with a median of $33.7 million in 2023.
- Annual changes were most pronounced in 2022 — Research & Development fell 19.36% — and 2024, when it surged 153.54%.
- Spyre Therapeutics' Research & Development stood at $14.3 million in 2022, then soared by 136.35% to $33.7 million in 2023, then soared by 49.88% to $50.5 million in 2024, then decreased by 11.58% to $44.6 million in 2025, then jumped by 35.34% to $60.4 million in 2026.
- The last three Research & Development figures came in at $60.4 million (Q1 2026), $44.6 million (Q4 2025), and $45.2 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | R&D (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | 4.32 Mn |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | 15.66 Mn |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | 626,092.00 |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -101.30 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | -2.30 Mn |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | 1.46 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | 357,444.00 |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 961.60 Mn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | -58.00 Mn |
| 10 | Spyre Therapeutics | 6.95 Bn | 6.95 Bn | - | 60.41 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 60.41 Mn |
| Dec 31, 2025 | 44.64 Mn |
| Sep 30, 2025 | 45.25 Mn |
| Jun 30, 2025 | 40.15 Mn |
| Mar 31, 2025 | 41.62 Mn |
| Dec 31, 2024 | 50.48 Mn |
| Sep 30, 2024 | 44.74 Mn |
| Jun 30, 2024 | 32.64 Mn |
| Mar 31, 2024 | 34.93 Mn |
| Dec 31, 2023 | 33.68 Mn |
| Sep 30, 2023 | 24.66 Mn |
| Jun 30, 2023 | 17.39 Mn |
| Mar 31, 2023 | 13.78 Mn |
| Dec 31, 2022 | 14.25 Mn |
| Sep 30, 2022 | 11.98 Mn |
| Jun 30, 2022 | 15.37 Mn |
| Mar 31, 2022 | 16.98 Mn |
| Dec 31, 2021 | 16.78 Mn |
| Sep 30, 2021 | 14.85 Mn |
| Jun 30, 2021 | 13.58 Mn |