Spyre Therapeutics (SYRE) Research & Development (2015 - 2026)

Spyre Therapeutics (SYRE) reported Research & Development of $60.4 million for Q1 2026, up 45.14% on a YoY basis from $41.6 million in Q1 2025, and up 35.34% quarter-over-quarter from $44.6 million in Q4 2025.

Spyre Therapeutics (SYRE) Research & Development (2015 - 2026) Analysis & Trends

Spyre Therapeutics has reported Research & Development for 12 years, with the latest figure at $60.4 million in Q1 2026.

  • For the quarter ending Q1 2026, Research & Development rose 45.14% year-over-year to $60.4 million; the trailing twelve-month figure through Mar 2026 stood at $190.4 million (up 12.36% YoY), and the FY2025 full-year result was $171.7 million, up 5.44% from the prior year.
  • Research & Development for Q1 2026 stood at $60.4 million, up from $44.6 million in the prior quarter.
  • The five-year high for Research & Development was $60.4 million in Q1 2026, with the low at $12.0 million in Q3 2022.
  • Historically, Research & Development has averaged $31.9 million across 5 years, with a median of $33.7 million in 2023.
  • Annual changes were most pronounced in 2022 — Research & Development fell 19.36% — and 2024, when it surged 153.54%.
  • Spyre Therapeutics' Research & Development stood at $14.3 million in 2022, then soared by 136.35% to $33.7 million in 2023, then soared by 49.88% to $50.5 million in 2024, then decreased by 11.58% to $44.6 million in 2025, then jumped by 35.34% to $60.4 million in 2026.
  • The last three Research & Development figures came in at $60.4 million (Q1 2026), $44.6 million (Q4 2025), and $45.2 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) R&D (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - 4.32 Mn
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - 15.66 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 626,092.00
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -101.30 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -2.30 Mn
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - 1.46 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - 357,444.00
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 961.60 Mn
9 Abivax 91.96 Bn 91.96 Bn - -58.00 Mn
10 Spyre Therapeutics 6.95 Bn 6.95 Bn - 60.41 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 60.41 Mn
Dec 31, 2025 44.64 Mn
Sep 30, 2025 45.25 Mn
Jun 30, 2025 40.15 Mn
Mar 31, 2025 41.62 Mn
Dec 31, 2024 50.48 Mn
Sep 30, 2024 44.74 Mn
Jun 30, 2024 32.64 Mn
Mar 31, 2024 34.93 Mn
Dec 31, 2023 33.68 Mn
Sep 30, 2023 24.66 Mn
Jun 30, 2023 17.39 Mn
Mar 31, 2023 13.78 Mn
Dec 31, 2022 14.25 Mn
Sep 30, 2022 11.98 Mn
Jun 30, 2022 15.37 Mn
Mar 31, 2022 16.98 Mn
Dec 31, 2021 16.78 Mn
Sep 30, 2021 14.85 Mn
Jun 30, 2021 13.58 Mn