Spyre Therapeutics, Inc. (SYRE) Insider Ownership

Historic Insider Ownership Trends

SYRE's three largest insider shareholders as of April 17, 2026 are Funds Management Llc Fairmount (Director, 4.02Mn shares), Funds Management Llc Fairmount (Director, 812.08K shares), Cameron Turtle (Chief Executive Officer, 627.54K shares).

Top Direct Holders

Insider ownership data is derived from the last 60 months of Form 4 SEC filings.
Holder Position Shares (Direct) Shares (Indirect) Report Date
Funds Management Llc Fairmount - 0 4,018,101 25 Apr, 2024
Funds Management Llc Fairmount - 0 812,076 29 Dec, 2023
Cameron Turtle Chief Executive Officer 627,540 0 03 Apr, 2026
Michael Thomas Henderson - 168,606 0 23 Jan, 2026
Jonathan Alspaugh Chief Financial Officer 165,372 0 15 Mar, 2022
Armen Shanafelt - 150,000 0 13 Dec, 2021
Scott L Burrows Chief Financial Officer 97,994 0 03 Apr, 2026
Marcio Souza - 90,000 0 25 Aug, 2022
Jr. Michael Conick Hanley Chief Commercial Officer 36,200 0 10 Jun, 2022
Jeffrey W. Albers - 0 27,360 08 Nov, 2024

* Please note that the shares above only reflect shares from the fund portfolio and the institutional portfolio. Shares from the personal portfolio are excluded from this Institutional Ownership Page. See these insiders' latest transactions here on Insider Page.

Recent Insider Transactions

Detailed insider trading activity based on Form 4 SEC filings.
Download Data
Transaction Date Insider Name Security Class Transaction Type Shares Traded Price Shares Remaining Ownership Code
01 Apr, 2026 Cameron Turtle Common Stock D 12,344 $49.20 630,196 D S
01 Apr, 2026 Scott L Burrows Common Stock A 7,500 $14.50 105,494 D M
01 Apr, 2026 Sheldon Sloan Common Stock A 7,958 $21.66 7,958 D M
01 Apr, 2026 Scott L Burrows Common Stock D 6,200 $49.21 99,294 D S
01 Apr, 2026 Sheldon Sloan Common Stock D 7,958 $50.00 0 D S
01 Apr, 2026 Cameron Turtle Common Stock D 2,656 $49.92 627,540 D S
01 Apr, 2026 Scott L Burrows Common Stock D 1,300 $49.98 97,994 D S
01 Apr, 2026 Sheldon Sloan Stock Option (Right to Buy) D 7,958 $0.00 87,542 D M
01 Apr, 2026 Scott L Burrows Stock Option (Right to Buy) D 7,500 $0.00 394,857 D M
03 Mar, 2026 Scott L Burrows Common Stock A 2,500 $14.50 100,494 D M
02 Mar, 2026 Cameron Turtle Common Stock D 5,900 $41.73 651,640 D S
03 Mar, 2026 Scott L Burrows Common Stock D 2,300 $40.56 98,194 D S
02 Mar, 2026 Cameron Turtle Common Stock D 9,100 $42.49 642,540 D S
03 Mar, 2026 Scott L Burrows Common Stock D 200 $41.66 97,994 D S
03 Mar, 2026 Scott L Burrows Stock Option (Right to Buy) D 2,500 $0.00 402,357 D M
02 Feb, 2026 Cameron Turtle Common Stock D 957 $31.82 671,583 D S
02 Feb, 2026 Cameron Turtle Common Stock D 14,043 $32.87 657,540 D S
21 Jan, 2026 Michael Thomas Henderson Common Stock A 63,227 $0.00 168,606 D J
09 Jan, 2026 Scott L Burrows Stock Option (Right to Buy) A 140,000 $0.00 140,000 D A
09 Jan, 2026 Cameron Turtle Stock Option (Right to Buy) A 528,000 $0.00 528,000 D A