Spyre Therapeutics SYRE
NASDAQ SYRE
$89.10 +1.85 (+2.12%)
As of: Sep 4, 2026 · 3:59 PM EDT

Spyre Therapeutics (SYRE) Retained Earnings (2015 - 2026)

Spyre Therapeutics' (SYRE) quarterly Retained Earnings came in at -$1.2 billion in Q1 2026, down 17.97% YoY from -$1.5 billion in Q1 2025, and down 6.42% on a QoQ basis from -$1.1 billion in Q4 2025.

Analysis

Spyre Therapeutics (SYRE) Retained Earnings (2015 - 2026) Analysis & Trends

Spyre Therapeutics (SYRE) has 12 years of Retained Earnings data on file, last reported at -$1.2 billion in Q1 2026.

  • Quarterly Retained Earnings fell 17.97% year-over-year to -$1.2 billion in Q1 2026, while the trailing twelve-month figure through Mar 2026 was -$1.2 billion (down 17.97% YoY) and the FY2025 annual result came in at -$1.1 billion, down 626563.89% from the prior year.
  • Retained Earnings declined to -$1.2 billion in Q1 2026, from -$1.1 billion in the prior quarter.
  • In the past five years, Retained Earnings ranged from a high of $302000.0 in Q4 2023 to a low of -$1.2 billion in Q1 2026.
  • A 5-year average of -$651.1 million and a median of -$701.2 million in 2023 frame the typical range for Retained Earnings.
  • Annual changes were most pronounced in 2022 — Retained Earnings tumbled 2128020.0% — and 2023, when it soared 100.07%.
  • Tracing SYRE's Retained Earnings over 5 years: stood at -$425.6 million in 2022, then soared by 100.07% to $302000.0 in 2023, then sank by 40.4% to $180000.0 in 2024, then sank by 626563.89% to -$1.1 billion in 2025, then slipped by 6.42% to -$1.2 billion in 2026.
  • The last three Retained Earnings figures came in at -$1.2 billion (Q1 2026), -$1.1 billion (Q4 2025), and -$1.1 billion (Q3 2025), per Business Quant data.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Retained Earnings (Qtr)
1 Vertex Pharmaceuticals 138.47 Bn 130.62 Bn 2.84 Bn 15.69 Bn
2 Regeneron Pharmaceuticals 85.18 Bn 77.19 Bn 3.93 Bn 37.62 Bn
3 Argenx Se 63.38 Bn 58.19 Bn 1.37 Bn 558.00 Mn
4 Moderna 58.09 Bn 52.95 Bn 52.00 Mn 5.10 Bn
5 Revolution Medicines 44.33 Bn 44.33 Bn - -4.00 Bn
6 BeOne Medicines 40.02 Bn 34.92 Bn 1.53 Bn 13.05 Bn
7 Alnylam Pharmaceuticals 35.57 Bn 32.27 Bn 992.69 Mn -6.33 Bn
8 Royalty Pharma 28.45 Bn 27.61 Bn - 4.38 Bn
9 Insmed 27.48 Bn 26.32 Bn 358.27 Mn 6.57 Bn
10 Spyre Therapeutics 7.53 Bn 7.53 Bn - -1.23 Bn
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 -1.23 Bn
Mar 31, 2026 -1.20 Bn
Dec 31, 2025 -1.13 Bn
Sep 30, 2025 -1.10 Bn
Jun 30, 2025 -1.10 Bn
Mar 31, 2025 -1.02 Bn
Dec 31, 2024 -972.43 Mn
Sep 30, 2024 -916.14 Mn
Jun 30, 2024 -847.11 Mn
Mar 31, 2024 -808.30 Mn
Dec 31, 2023 -764.41 Mn
Sep 30, 2023 -701.23 Mn
Jun 30, 2023 -661.13 Mn
Mar 31, 2023 -444.05 Mn
Dec 31, 2022 -425.62 Mn
Sep 30, 2022 -406.80 Mn
Jun 30, 2022 -388.60 Mn
Mar 31, 2022 -366.25 Mn
Dec 31, 2021 -341.81 Mn
Sep 30, 2021 -321.40 Mn