Spyre Therapeutics (SYRE) Retained Earnings (2015 - 2026)
Spyre Therapeutics' (SYRE) quarterly Retained Earnings came in at -$1.2 billion in Q1 2026, down 17.97% YoY from -$1.5 billion in Q1 2025, and down 6.42% on a QoQ basis from -$1.1 billion in Q4 2025.
Analysis
Spyre Therapeutics (SYRE) Retained Earnings (2015 - 2026) Analysis & Trends
Spyre Therapeutics (SYRE) has 12 years of Retained Earnings data on file, last reported at -$1.2 billion in Q1 2026.
- Quarterly Retained Earnings fell 17.97% year-over-year to -$1.2 billion in Q1 2026, while the trailing twelve-month figure through Mar 2026 was -$1.2 billion (down 17.97% YoY) and the FY2025 annual result came in at -$1.1 billion, down 626563.89% from the prior year.
- Retained Earnings declined to -$1.2 billion in Q1 2026, from -$1.1 billion in the prior quarter.
- In the past five years, Retained Earnings ranged from a high of $302000.0 in Q4 2023 to a low of -$1.2 billion in Q1 2026.
- A 5-year average of -$651.1 million and a median of -$701.2 million in 2023 frame the typical range for Retained Earnings.
- Annual changes were most pronounced in 2022 — Retained Earnings tumbled 2128020.0% — and 2023, when it soared 100.07%.
- Tracing SYRE's Retained Earnings over 5 years: stood at -$425.6 million in 2022, then soared by 100.07% to $302000.0 in 2023, then sank by 40.4% to $180000.0 in 2024, then sank by 626563.89% to -$1.1 billion in 2025, then slipped by 6.42% to -$1.2 billion in 2026.
- The last three Retained Earnings figures came in at -$1.2 billion (Q1 2026), -$1.1 billion (Q4 2025), and -$1.1 billion (Q3 2025), per Business Quant data.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Retained Earnings (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 138.47 Bn | 130.62 Bn | 2.84 Bn | 15.69 Bn |
| 2 | Regeneron Pharmaceuticals | 85.18 Bn | 77.19 Bn | 3.93 Bn | 37.62 Bn |
| 3 | Argenx Se | 63.38 Bn | 58.19 Bn | 1.37 Bn | 558.00 Mn |
| 4 | Moderna | 58.09 Bn | 52.95 Bn | 52.00 Mn | 5.10 Bn |
| 5 | Revolution Medicines | 44.33 Bn | 44.33 Bn | - | -4.00 Bn |
| 6 | BeOne Medicines | 40.02 Bn | 34.92 Bn | 1.53 Bn | 13.05 Bn |
| 7 | Alnylam Pharmaceuticals | 35.57 Bn | 32.27 Bn | 992.69 Mn | -6.33 Bn |
| 8 | Royalty Pharma | 28.45 Bn | 27.61 Bn | - | 4.38 Bn |
| 9 | Insmed | 27.48 Bn | 26.32 Bn | 358.27 Mn | 6.57 Bn |
| 10 | Spyre Therapeutics | 7.53 Bn | 7.53 Bn | - | -1.23 Bn |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -1.23 Bn |
| Mar 31, 2026 | -1.20 Bn |
| Dec 31, 2025 | -1.13 Bn |
| Sep 30, 2025 | -1.10 Bn |
| Jun 30, 2025 | -1.10 Bn |
| Mar 31, 2025 | -1.02 Bn |
| Dec 31, 2024 | -972.43 Mn |
| Sep 30, 2024 | -916.14 Mn |
| Jun 30, 2024 | -847.11 Mn |
| Mar 31, 2024 | -808.30 Mn |
| Dec 31, 2023 | -764.41 Mn |
| Sep 30, 2023 | -701.23 Mn |
| Jun 30, 2023 | -661.13 Mn |
| Mar 31, 2023 | -444.05 Mn |
| Dec 31, 2022 | -425.62 Mn |
| Sep 30, 2022 | -406.80 Mn |
| Jun 30, 2022 | -388.60 Mn |
| Mar 31, 2022 | -366.25 Mn |
| Dec 31, 2021 | -341.81 Mn |
| Sep 30, 2021 | -321.40 Mn |