Spyre Therapeutics (SYRE) Share-based Compensation (2015 - 2026)

Spyre Therapeutics (SYRE) posted Share-based Compensation of $12.8 million for Q1 2026, up 30.53% on a QoQ basis from $9.8 million in Q4 2025, and up 44.55% year-over-year from $8.9 million in Q1 2025.

Spyre Therapeutics (SYRE) Share-based Compensation (2015 - 2026) Analysis & Trends

Spyre Therapeutics' Share-based Compensation history runs 12 years deep, the most recent figure standing at $12.8 million for Q1 2026.

  • Quarterly Share-based Compensation rose 44.55% year-over-year to $12.8 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was $32.3 million (up 753.61% YoY) and the FY2025 annual result came in at $37.6 million, changed N/A from the prior year.
  • Share-based Compensation was $12.8 million for Q1 2026 at Spyre Therapeutics, up from $9.8 million in the prior quarter.
  • Across five years, Share-based Compensation topped out at $181.3 million in Q4 2023 and bottomed at -$35.6 million in Q4 2024.
  • A 5-year average of $15.1 million and a median of $7.9 million in 2022 frame the typical range for Share-based Compensation.
  • Annual changes were most pronounced in 2023 — Share-based Compensation surged 2450.15% — and 2024, when it tumbled 119.63%.
  • Spyre Therapeutics' Share-based Compensation stood at $7.1 million in 2022, then soared by 2450.15% to $181.3 million in 2023, then tumbled by 119.63% to -$35.6 million in 2024, then jumped by 127.56% to $9.8 million in 2025, then surged by 30.53% to $12.8 million in 2026.
  • Business Quant data shows SYRE's Share-based Compensation at $12.8 million in Q1 2026, $9.8 million in Q4 2025, and $300000.0 in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Share-based Compensation (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - 6.39 Mn
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 9.26 Mn
4 NuCana 279.75 Bn 279.75 Bn - 1.18 Mn
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 166.40 Mn
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn 257.40 Mn
7 Belite Bio 62.51 Bn 62.51 Bn - -
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn -
9 Revolution Medicines 37.78 Bn 37.78 Bn - 87.30 Mn
10 Spyre Therapeutics 257.83 Mn 257.83 Mn - 12.81 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 12.81 Mn
Mar 31, 2026 12.81 Mn
Dec 31, 2025 9.81 Mn
Dec 31, 2025 9.81 Mn
Sep 30, 2025 300,000.00
Sep 30, 2025 300,000.00
Jun 30, 2025 9.38 Mn
Jun 30, 2025 9.38 Mn
Mar 31, 2025 8.86 Mn
Mar 31, 2025 8.86 Mn
Dec 31, 2024 -35.60 Mn
Dec 31, 2024 -35.60 Mn
Sep 30, 2024 13.10 Mn
Sep 30, 2024 13.10 Mn
Jun 30, 2024 8.70 Mn
Jun 30, 2024 8.70 Mn
Mar 31, 2024 13.80 Mn
Mar 31, 2024 13.80 Mn
Dec 31, 2023 181.34 Mn
Dec 31, 2023 181.34 Mn