Spyre Therapeutics SYRE
NASDAQ SYRE
$104.48 -4.52 (-4.15%)
At close: Nov 10, 2026 · 4:00 PM EST

Spyre Therapeutics (SYRE) EBITDA Margin (2017 - 2023)

Updated

Spyre Therapeutics (SYRE) reported EBITDA Margin of -27264.00% for FY2023, down 23691.05 percentage points from -3572.95% in FY2022.

Analysis

Spyre Therapeutics (SYRE) EBITDA Margin (2017 - 2023) Analysis & Trends

Dating back to FY2016, Spyre Therapeutics' EBITDA Margin record includes 6 years.

  • EBITDA Margin has a five-year change of -26105.97 percentage points (FY2018 to FY2023).
  • The FY2023 figure ranks as the lowest annual EBITDA Margin in data going back to FY2016.
  • According to Business Quant data, EBITDA Margin came in at -3572.95% in FY2022 (-3231.03 pp) and -341.92% in FY2021.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBITDA Margin (Qtr)
1 Eli Lilly 1,348.13 Bn 1,321.74 Bn 20.46 Bn 36.69%
2 Johnson & Johnson 675.90 Bn 595.76 Bn 17.30 Bn 32.68%
3 AbbVie 519.45 Bn 487.50 Bn 13.12 Bn 46.88%
4 Merck 364.95 Bn 327.95 Bn 13.19 Bn 40.60%
5 Novartis Ag 311.58 Bn 285.16 Bn - -
6 Astrazeneca 289.34 Bn 262.94 Bn 13.26 Bn 39.77%
7 Amgen 251.64 Bn 203.30 Bn 7.58 Bn 46.62%
8 Gilead Sciences 212.05 Bn 187.07 Bn 6.73 Bn 50.63%
9 Pfizer 167.35 Bn 115.00 Bn 12.56 Bn 42.49%
10 Spyre Therapeutics 9.40 Bn 5.68 Bn - -
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2023 -23,093.90%
Mar 31, 2023 -9,304.04%
Dec 31, 2022 -11,176.79%
Sep 30, 2022 -10,548.28%
Jun 30, 2022 -3,527.20%
Mar 31, 2022 -1,764.90%
Dec 31, 2021 -549.70%
Sep 30, 2021 -1,421.09%
Jun 30, 2021 -46.05%
Jun 30, 2018 -403.49%
Mar 31, 2018 -541.39%
Dec 31, 2017 -442.41%
Sep 30, 2017 -628.79%
Jun 30, 2017 -450.17%
Mar 31, 2017 -639.41%
API Access

Spyre Therapeutics EBITDA Margin API

Pull this series into your own models, spreadsheets and apps with the Business Quant Historical Metrics API. The request below matches the chart above — change the frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.

https://data.businessquant.com/historic?slug=ebitda-margin&ticker=SYRE&period=max&api_key=YOUR_API_KEY