Spyre Therapeutics (SYRE) Net Cash Flow (2015 - 2026)
Spyre Therapeutics (SYRE) posted Net Cash Flow of $64.82 million for Q2 2026, up 95.4% from $33.17 million a year earlier and up 465.4% from the prior quarter.
Powered by 
Analysis
Spyre Therapeutics (SYRE) Net Cash Flow (2015 - 2026) Analysis & Trends
For the trailing twelve months through Jun 30, 2026, Net Cash Flow at Spyre Therapeutics was $80.35 million, up 122.0% year-over-year; for FY2025, it was -$3.7 million.
- In prior years, Spyre Therapeutics' Net Cash Flow was -$99.79 million in FY2024, $152.77 million in FY2023 (+681.8%), $19.54 million in FY2022 and -$74.94 million in FY2021.
- The Q2 2026 figure stands as the highest quarterly Net Cash Flow since Q4 2023.
- According to Business Quant data, Net Cash Flow for the three prior quarters was $11.46 million (Q1 2026), $20.82 million (Q4 2025) and -$16.76 million (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | NCF (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 638.12 Bn | 556.64 Bn | 17.26 Bn | -1.27 Bn |
| 2 | AbbVie | 462.60 Bn | 435.75 Bn | 12.70 Bn | -2.82 Bn |
| 3 | Merck | 358.70 Bn | 313.13 Bn | 12.21 Bn | 1.53 Bn |
| 4 | Novartis Ag | 272.16 Bn | 228.03 Bn | 11.24 Bn | 757.00 Mn |
| 5 | Astrazeneca | 250.36 Bn | 223.92 Bn | 12.86 Bn | 1.62 Bn |
| 6 | Amgen | 227.87 Bn | 183.27 Bn | 7.24 Bn | 1.95 Bn |
| 7 | Gilead Sciences | 184.97 Bn | 159.08 Bn | 6.22 Bn | -4.43 Bn |
| 8 | Pfizer | 162.61 Bn | 109.56 Bn | 10.94 Bn | -722.00 Mn |
| 9 | Vertex Pharmaceuticals | 132.45 Bn | 104.46 Bn | 2.84 Bn | 652.90 Mn |
| 10 | Spyre Therapeutics | 7.84 Bn | 7.84 Bn | - | 64.82 Mn |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 64.82 Mn |
| Mar 31, 2026 | 11.46 Mn |
| Dec 31, 2025 | 20.82 Mn |
| Sep 30, 2025 | -16.76 Mn |
| Jun 30, 2025 | 33.17 Mn |
| Mar 31, 2025 | -40.93 Mn |
| Dec 31, 2024 | 17.86 Mn |
| Sep 30, 2024 | 26.10 Mn |
| Jun 30, 2024 | -182.41 Mn |
| Mar 31, 2024 | 38.66 Mn |
| Dec 31, 2023 | 97.30 Mn |
| Sep 30, 2023 | -144.76 Mn |
| Jun 30, 2023 | 200.11 Mn |
| Mar 31, 2023 | 126,000.00 |
| Dec 31, 2022 | -4.15 Mn |
| Sep 30, 2022 | 1.30 Mn |
| Jun 30, 2022 | 22.88 Mn |
| Mar 31, 2022 | -492,000.00 |
| Dec 31, 2021 | -9.53 Mn |
| Sep 30, 2021 | -10.08 Mn |
API Access
Spyre Therapeutics Net Cash Flow API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=net-cash-flow&ticker=SYRE&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "net-cash-flow", "ticker": "SYRE", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=net-cash-flow&ticker=SYRE&period=max&api_key=YOUR_API_KEY");
const data = await res.json();