Spyre Therapeutics (SYRE) Net Cash Flow (2015 - 2026)
Spyre Therapeutics posted quarterly Net Cash Flow of $11.5 million for Q1 2026, up 128.01% year-on-year from $5.0 million in Q1 2025, and down 44.95% on a QoQ basis from $20.8 million in Q4 2025.
Spyre Therapeutics (SYRE) has 12 years of Net Cash Flow data on file, last reported at $11.5 million in Q1 2026.
- For the quarter ending Q1 2026, Net Cash Flow rose 128.01% year-over-year to $11.5 million; the trailing twelve-month figure through Mar 2026 stood at $48.7 million (up 127.14% YoY), and the FY2025 full-year result was -$3.7 million, up 96.29% from the prior year.
- Net Cash Flow for Q1 2026 stood at $11.5 million, down from $20.8 million in the prior quarter.
- Across five years, Net Cash Flow topped out at $200.1 million in Q2 2023 and bottomed at -$182.4 million in Q2 2024.
- The 5-year median for Net Cash Flow is $11.5 million (2026), against an average of $4.7 million.
- The widest annual swing landed in 2023, when Net Cash Flow slumped 11226.75%; it then jumped 30582.54% in 2024.
- A 5-year view of Net Cash Flow shows it stood at -$4.1 million in 2022, then soared by 2445.66% to $97.3 million in 2023, then slumped by 81.65% to $17.9 million in 2024, then gained by 16.61% to $20.8 million in 2025, then slumped by 44.95% to $11.5 million in 2026.
- The last three Net Cash Flow figures came in at $11.5 million (Q1 2026), $20.8 million (Q4 2025), and -$16.8 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Cash Flow (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | 2.44 Mn |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | 625.70 Mn |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | -2.44 Mn |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 457.40 Mn |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | -152.20 Mn |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 60.68 Mn |
| 10 | Spyre Therapeutics | 5.55 Bn | 5.55 Bn | - | 11.46 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 11.46 Mn |
| Mar 31, 2026 | 11.46 Mn |
| Dec 31, 2025 | 20.82 Mn |
| Dec 31, 2025 | 20.82 Mn |
| Sep 30, 2025 | -16.76 Mn |
| Sep 30, 2025 | -16.76 Mn |
| Jun 30, 2025 | 33.17 Mn |
| Jun 30, 2025 | 33.17 Mn |
| Mar 31, 2025 | -40.93 Mn |
| Mar 31, 2025 | -40.93 Mn |
| Dec 31, 2024 | 17.86 Mn |
| Dec 31, 2024 | 17.86 Mn |
| Sep 30, 2024 | 26.10 Mn |
| Sep 30, 2024 | 26.10 Mn |
| Jun 30, 2024 | -182.41 Mn |
| Jun 30, 2024 | -182.41 Mn |
| Mar 31, 2024 | 38.66 Mn |
| Mar 31, 2024 | 38.66 Mn |
| Dec 31, 2023 | 97.30 Mn |
| Dec 31, 2023 | 97.30 Mn |
| Sep 30, 2023 | -144.76 Mn |
| Sep 30, 2023 | -144.76 Mn |
| Jun 30, 2023 | 200.11 Mn |
| Jun 30, 2023 | 200.11 Mn |
| Mar 31, 2023 | 126,000.00 |
| Mar 31, 2023 | 126,000.00 |
| Dec 31, 2022 | -4.15 Mn |
| Dec 31, 2022 | -4.15 Mn |
| Sep 30, 2022 | 1.30 Mn |
| Sep 30, 2022 | 1.30 Mn |
| Jun 30, 2022 | 22.88 Mn |
| Jun 30, 2022 | 22.88 Mn |
| Mar 31, 2022 | -492,000.00 |
| Mar 31, 2022 | -492,000.00 |
| Dec 31, 2021 | -9.53 Mn |
| Dec 31, 2021 | -9.53 Mn |
| Sep 30, 2021 | -10.08 Mn |
| Sep 30, 2021 | -10.08 Mn |
| Jun 30, 2021 | -45.47 Mn |
| Jun 30, 2021 | -45.47 Mn |
| Mar 31, 2021 | -9.87 Mn |
| Mar 31, 2021 | -9.87 Mn |
| Dec 31, 2020 | 36.17 Mn |
| Dec 31, 2020 | 36.17 Mn |
| Sep 30, 2020 | -11.49 Mn |
| Sep 30, 2020 | -11.49 Mn |
| Jun 30, 2020 | 53.12 Mn |
| Jun 30, 2020 | 53.12 Mn |
| Mar 31, 2020 | -6.66 Mn |
| Mar 31, 2020 | -6.66 Mn |
| Dec 31, 2019 | -5.29 Mn |
| Dec 31, 2019 | -5.29 Mn |
| Sep 30, 2019 | -885,000.00 |
| Sep 30, 2019 | -885,000.00 |
| Jun 30, 2019 | -58.72 Mn |
| Jun 30, 2019 | -58.72 Mn |
| Mar 31, 2019 | 63.18 Mn |
| Mar 31, 2019 | 63.18 Mn |
| Dec 31, 2018 | 7.93 Mn |
| Dec 31, 2018 | 7.93 Mn |
| Sep 30, 2018 | -6.05 Mn |
| Sep 30, 2018 | -6.05 Mn |
| Jun 30, 2018 | 9.82 Mn |
| Jun 30, 2018 | 9.82 Mn |
| Mar 31, 2018 | -2.06 Mn |
| Mar 31, 2018 | -2.06 Mn |
| Dec 31, 2017 | -345,000.00 |
| Dec 31, 2017 | -345,000.00 |
| Sep 30, 2017 | -13.77 Mn |
| Sep 30, 2017 | -13.77 Mn |
| Jun 30, 2017 | 10.13 Mn |
| Jun 30, 2017 | 10.13 Mn |
| Mar 31, 2017 | -30.95 Mn |
| Mar 31, 2017 | -30.95 Mn |
| Dec 31, 2016 | -1.80 Mn |
| Dec 31, 2016 | -1.80 Mn |
| Sep 30, 2016 | -21.08 Mn |
| Sep 30, 2016 | -21.08 Mn |
| Jun 30, 2016 | 46.61 Mn |
| Jun 30, 2016 | 46.61 Mn |
| Mar 31, 2016 | -5.28 Mn |
| Mar 31, 2016 | -5.28 Mn |
| Dec 31, 2015 | -1.55 Mn |
| Dec 31, 2015 | -1.55 Mn |
| Sep 30, 2015 | -8.24 Mn |
| Sep 30, 2015 | -8.24 Mn |
| Jun 30, 2015 | -4.71 Mn |
| Jun 30, 2015 | -4.71 Mn |
| Mar 31, 2015 | 41.18 Mn |
| Mar 31, 2015 | 41.18 Mn |