Spero Therapeutics (SPRO) Return on Invested Capital (2023 - 2025)

Spero Therapeutics (SPRO) has 3 years of Return on Invested Capital data on file, last reported at 0.0% in Q4 2025.

• For the quarter ending Q4 2025, Return on Invested Capital rose 2.0% year-over-year to 0.0%; the trailing twelve-month figure through Dec 2025 stood at 0.0% (up 2.0% YoY), and the FY2025 full-year result was 0.0%, changed N/A from the prior year.
• Return on Invested Capital for Q4 2025 stood at 0.0%, up from 0.02% in the prior quarter.
• Across five years, Return on Invested Capital topped out at 0.0% in Q4 2023 and bottomed at 0.02% in Q3 2025.
• The 3-year median for Return on Invested Capital is 0.0% (2024), against an average of 0.01%.
• The widest annual swing landed in 2024, when Return on Invested Capital fell 2 bps; it then gained 2 bps in 2025.
• A 3-year view of Return on Invested Capital shows it stood at 0.0% in 2023, then slumped by 596 bps to 0.01% in 2024, then jumped by 110 bps to 0.0% in 2025.
• The last three Return on Invested Capital figures came in at 0.0% (Q4 2025), 0.02% (Q3 2025), and 0.01% (Q4 2024), per Business Quant data.

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