Growth Metrics

Spero Therapeutics (SPRO) EBIT (2016 - 2026)

Spero Therapeutics posted quarterly EBIT of -$7.5 million for Q1 2026, up 48.83% year-on-year from -$5.1 million in Q1 2025, and down 124.0% on a QoQ basis from $31.4 million in Q4 2025.

Spero Therapeutics (SPRO) has 11 years of EBIT data on file, last reported at -$7.5 million in Q1 2026.

  • For the quarter ending Q1 2026, EBIT rose 48.83% year-over-year to -$7.5 million; the trailing twelve-month figure through Mar 2026 stood at $13.5 million (up 117.37% YoY), and the FY2025 full-year result was $6.3 million, up 108.61% from the prior year.
  • EBIT for Q1 2026 stood at -$7.5 million, down from $31.4 million in the prior quarter.
  • Across five years, EBIT topped out at $54.5 million in Q4 2023 and bottomed at -$30.2 million in Q1 2022.
  • The 5-year median for EBIT is -$12.9 million (2023), against an average of -$5.5 million.
  • The widest annual swing landed in 2024, when EBIT tumbled 861.38%; it then jumped 223.68% in 2025.
  • A 5-year view of EBIT shows it stood at $26.8 million in 2022, then surged by 103.41% to $54.5 million in 2023, then sank by 146.63% to -$25.4 million in 2024, then surged by 223.68% to $31.4 million in 2025, then sank by 124.0% to -$7.5 million in 2026.
  • The last three EBIT figures came in at -$7.5 million (Q1 2026), $31.4 million (Q4 2025), and -$7.9 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBIT (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - -2.97 Mn
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn -19.70 Mn
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - -15.76 Mn
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 1.14 Bn
7 Evaxion A 62.56 Bn 62.54 Bn - -3.82 Mn
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 642.90 Mn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 268.64 Mn
10 Spero Therapeutics 162.39 Mn 106.26 Mn - -7.54 Mn

Historic Data

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DateValue
Mar 31, 2026 -7.54 Mn
Dec 31, 2025 31.41 Mn
Sep 30, 2025 -7.92 Mn
Jun 30, 2025 -2.44 Mn
Mar 31, 2025 -14.73 Mn
Dec 31, 2024 -25.39 Mn
Sep 30, 2024 -18.59 Mn
Jun 30, 2024 -19.06 Mn
Mar 31, 2024 -13.98 Mn
Dec 31, 2023 54.46 Mn
Sep 30, 2023 -1.93 Mn
Jun 30, 2023 -12.89 Mn
Mar 31, 2023 -14.23 Mn
Dec 31, 2022 26.77 Mn
Sep 30, 2022 -11.68 Mn
Jun 30, 2022 -26.08 Mn
Mar 31, 2022 -30.21 Mn
Dec 31, 2021 -27.50 Mn
Sep 30, 2021 -22.52 Mn
Jun 30, 2021 -18.54 Mn
Mar 31, 2021 -19.40 Mn
Dec 31, 2020 -18.80 Mn
Sep 30, 2020 -19.02 Mn
Jun 30, 2020 -18.48 Mn
Mar 31, 2020 -22.82 Mn
Dec 31, 2019 -25.88 Mn
Sep 30, 2019 -17.99 Mn
Jun 30, 2019 -13.65 Mn
Mar 31, 2019 -5.70 Mn
Dec 31, 2018 -11.08 Mn
Sep 30, 2018 -10.94 Mn
Jun 30, 2018 -9.97 Mn
Mar 31, 2018 -10.82 Mn
Dec 31, 2017 -14.00 Mn
Sep 30, 2017 -9.97 Mn
Jun 30, 2017 -10.17 Mn
Mar 31, 2017 -7.60 Mn
Dec 31, 2016 -8.81 Mn
Sep 30, 2016 -7.91 Mn