Growth Metrics

Spero Therapeutics (SPRO) Invested Capital (2016 - 2026)

Spero Therapeutics posted quarterly Invested Capital of $52.9 million for Q1 2026, up 56.54% year-on-year from $33.8 million in Q1 2025, and down 10.31% on a QoQ basis from $59.0 million in Q4 2025.

Spero Therapeutics (SPRO) has 11 years of Invested Capital data on file, last reported at $52.9 million in Q1 2026.

  • For the quarter ending Q1 2026, Invested Capital rose 56.54% year-over-year to $52.9 million; the trailing twelve-month figure through Mar 2026 stood at $52.9 million (up 56.54% YoY), and the FY2025 full-year result was $59.0 million, up 27.96% from the prior year.
  • Invested Capital for Q1 2026 stood at $52.9 million, down from $59.0 million in the prior quarter.
  • Across five years, Invested Capital topped out at $106.9 million in Q4 2023 and bottomed at $26.5 million in Q3 2025.
  • The 5-year median for Invested Capital is $54.8 million (2023), against an average of $57.8 million.
  • The widest annual swing landed in 2022, when Invested Capital sank 70.84%; it then soared 64.61% in 2023.
  • A 5-year view of Invested Capital shows it stood at $75.9 million in 2022, then jumped by 40.77% to $106.9 million in 2023, then slumped by 56.85% to $46.1 million in 2024, then gained by 27.96% to $59.0 million in 2025, then declined by 10.31% to $52.9 million in 2026.
  • The last three Invested Capital figures came in at $52.9 million (Q1 2026), $59.0 million (Q4 2025), and $26.5 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Invested Cap. (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - 595,226.00
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn -
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - 110.96 Mn
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - 14.38 Mn
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 19.36 Bn
7 Evaxion A 62.56 Bn 62.54 Bn - -
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 31.42 Bn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 1.08 Bn
10 Spero Therapeutics 162.39 Mn 106.26 Mn - 52.93 Mn

Historic Data

Download Data 🔒
DateValue
Mar 31, 2026 52.93 Mn
Dec 31, 2025 59.02 Mn
Sep 30, 2025 26.49 Mn
Jun 30, 2025 32.83 Mn
Mar 31, 2025 33.81 Mn
Dec 31, 2024 46.12 Mn
Sep 30, 2024 65.51 Mn
Jun 30, 2024 80.50 Mn
Mar 31, 2024 96.25 Mn
Dec 31, 2023 106.89 Mn
Sep 30, 2023 53.71 Mn
Jun 30, 2023 54.78 Mn
Mar 31, 2023 64.84 Mn
Dec 31, 2022 75.93 Mn
Sep 30, 2022 32.63 Mn
Jun 30, 2022 36.04 Mn
Mar 31, 2022 63.47 Mn
Dec 31, 2021 88.29 Mn
Sep 30, 2021 111.90 Mn
Jun 30, 2021 90.25 Mn
Mar 31, 2021 118.85 Mn
Dec 31, 2020 132.04 Mn
Sep 30, 2020 132.79 Mn
Jun 30, 2020 73.71 Mn
Mar 31, 2020 82.43 Mn
Dec 31, 2019 74.57 Mn
Sep 30, 2019 93.26 Mn
Jun 30, 2019 109.89 Mn
Mar 31, 2019 113.55 Mn
Dec 31, 2018 116.08 Mn
Sep 30, 2018 125.78 Mn
Jun 30, 2018 65.89 Mn
Mar 31, 2018 75.12 Mn
Dec 31, 2017 85.18 Mn
Sep 30, 2017 -81.62 Mn
Dec 31, 2016 -46.54 Mn