Spero Therapeutics (SPRO) EV to CFO (2017 - 2026)
Spero Therapeutics' (SPRO) quarterly EV to CFO came in at 14.52 in Q2 2026, down 94.93% on a YoY basis from 286.5 in Q2 2025, and down 390.25% quarter-over-quarter from 5.0 in Q1 2026.
Analysis
Spero Therapeutics (SPRO) EV to CFO (2017 - 2026) Analysis & Trends
Spero Therapeutics (SPRO) has reported EV to CFO for 10 consecutive years, with 14.52 the latest figure, recorded in Q2 2026.
- For the quarter ending Q2 2026, EV to CFO fell 94.93% year-over-year to 14.52; the trailing twelve-month figure through Jun 2026 stood at 3.97 (up 197.43% YoY), and the FY2025 full-year result was 7.22, down 4966.29% from the prior year.
- EV to CFO eased to 14.52 in Q2 2026 per SPRO's latest filing, from 5.0 in the prior quarter.
- Across five years, EV to CFO topped out at 5.0 in Q1 2026 and bottomed at 36.85 in Q3 2022.
- Historically, EV to CFO has averaged 3.59 across 5 years, with a median of 0.21 in 2024.
- The widest YoY moves for EV to CFO: up 1295.33% in 2025, down 7544.54% in 2025.
- Over 5 years, EV to CFO stood at 0.99 in 2022, then jumped by 90.91% to 0.09 in 2023, then slumped by 58.48% to 0.14 in 2024, then slumped by 7544.54% to 10.92 in 2025, then sank by 32.94% to 14.52 in 2026.
- According to Business Quant data, EV to CFO over the past three periods registered 14.52, 5.0, and 10.92 for Q2 2026, Q1 2026, and Q4 2025 respectively.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) |
|---|---|---|---|---|
| 1 | Amgen | 211.73 Bn | 197.74 Bn | 7.24 Bn |
| 2 | Gilead Sciences | 180.92 Bn | 177.74 Bn | 6.22 Bn |
| 3 | Vertex Pharmaceuticals | 132.16 Bn | 124.30 Bn | 2.84 Bn |
| 4 | Regeneron Pharmaceuticals | 82.89 Bn | 74.90 Bn | 3.93 Bn |
| 5 | Argenx Se | 61.41 Bn | 56.23 Bn | 1.37 Bn |
| 6 | Moderna | 53.99 Bn | 48.85 Bn | 52.00 Mn |
| 7 | Alnylam Pharmaceuticals | 34.48 Bn | 31.18 Bn | 992.69 Mn |
| 8 | Biogen | 31.15 Bn | 29.86 Bn | 1.96 Bn |
| 9 | Roivant Sciences | 30.05 Bn | 30.05 Bn | 1.16 Mn |
| 10 | Spero Therapeutics | 67.82 Mn | 17.05 Mn | - |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -14.52 |
| Mar 31, 2026 | 5.00 |
| Dec 31, 2025 | -10.92 |
| Sep 30, 2025 | 3.29 |
| Jun 30, 2025 | -7.45 |
| Mar 31, 2025 | 2.16 |
| Dec 31, 2024 | -0.14 |
| Sep 30, 2024 | -0.27 |
| Jun 30, 2024 | -0.36 |
| Mar 31, 2024 | 1.75 |
| Dec 31, 2023 | -0.09 |
| Sep 30, 2023 | -1.87 |
| Jun 30, 2023 | 0.08 |
| Mar 31, 2023 | 1.56 |
| Dec 31, 2022 | -0.99 |
| Sep 30, 2022 | -36.85 |
| Jun 30, 2022 | 0.84 |
| Mar 31, 2022 | -5.78 |
| Dec 31, 2021 | -13.61 |
| Sep 30, 2021 | -94.86 |