Spero Therapeutics (SPRO) Return on Sales (2016 - 2026)
Spero Therapeutics posted quarterly Return on Sales of 0.28% for Q1 2026, down 26.0% year-on-year from 0.38% in Q1 2025, and down 550.84% on a QoQ basis from 0.04% in Q4 2025.
Spero Therapeutics (SPRO) has 11 years of Return on Sales data on file, last reported at 0.28% in Q1 2026.
- For the quarter ending Q1 2026, Return on Sales fell 26.0% year-over-year to 0.28%; the trailing twelve-month figure through Mar 2026 stood at 0.01% (up 3.0% YoY), and the FY2025 full-year result was 0.01%, up 2.0% from the prior year.
- Return on Sales for Q1 2026 stood at 0.28%, down from 0.04% in the prior quarter.
- Across five years, Return on Sales topped out at 0.02% in Q4 2022 and bottomed at 2.72% in Q3 2024.
- The 5-year median for Return on Sales is 0.04% (2025), against an average of 0.25%.
- The widest annual swing landed in 2024, when Return on Sales tumbled 258 bps; it then soared 271 bps in 2025.
- A 5-year view of Return on Sales shows it stood at 0.02% in 2022, then tumbled by 49 bps to 0.01% in 2023, then sank by 195 bps to 0.01% in 2024, then sank by 439 bps to 0.04% in 2025, then plunged by 551 bps to 0.28% in 2026.
- The last three Return on Sales figures came in at 0.28% (Q1 2026), 0.04% (Q4 2025), and 0.01% (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROS (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | - |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | 0.00% |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 0.00% |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | 0.00% |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 0.00% |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 0.00% |
| 10 | Spero Therapeutics | 162.39 Mn | 106.26 Mn | - | -0.28% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -0.28% |
| Dec 31, 2025 | -0.04% |
| Sep 30, 2025 | -0.01% |
| Jun 30, 2025 | 0.00% |
| Mar 31, 2025 | -0.02% |
| Dec 31, 2024 | -0.01% |
| Sep 30, 2024 | -2.72% |
| Jun 30, 2024 | -0.03% |
| Mar 31, 2024 | -0.01% |
| Dec 31, 2023 | 0.01% |
| Sep 30, 2023 | -0.15% |
| Jun 30, 2023 | -0.04% |
| Mar 31, 2023 | -0.59% |
| Dec 31, 2022 | 0.02% |
| Sep 30, 2022 | -0.06% |
| Jun 30, 2022 | -0.13% |
| Mar 31, 2022 | -0.15% |
| Dec 31, 2021 | -0.02% |
| Sep 30, 2021 | -0.32% |
| Jun 30, 2021 | -0.09% |
| Mar 31, 2021 | -0.03% |
| Dec 31, 2020 | -0.23% |
| Sep 30, 2020 | -5.00% |
| Jun 30, 2020 | -0.11% |
| Mar 31, 2020 | -0.13% |
| Dec 31, 2019 | -0.37% |
| Sep 30, 2019 | -0.04% |
| Jun 30, 2019 | -1.98% |
| Mar 31, 2019 | -0.01% |
| Dec 31, 2018 | -0.06% |
| Sep 30, 2018 | -0.16% |
| Jun 30, 2018 | -0.22% |
| Mar 31, 2018 | -0.24% |
| Dec 31, 2017 | -0.14% |
| Sep 30, 2017 | -0.16% |
| Jun 30, 2017 | -0.41% |
| Mar 31, 2017 | -0.54% |
| Dec 31, 2016 | 1.36% |
| Sep 30, 2016 | -0.79% |