Spero Therapeutics (SPRO) Gains from Investment Securities (2016 - 2025)

Spero Therapeutics (SPRO) reported Gains from Investment Securities of $2.4 million for Q4 2025, down 14.72% on a YoY basis from $2.8 million in Q4 2024, and up 479.23% quarter-over-quarter from $414417.0 in Q3 2025.

Spero Therapeutics (SPRO) Gains from Investment Securities (2016 - 2025) Analysis & Trends

Spero Therapeutics has reported Gains from Investment Securities for 10 years, with the latest figure at $2.4 million in Q4 2025.

  • For the quarter ending Q4 2025, Gains from Investment Securities fell 14.72% year-over-year to $2.4 million; the trailing twelve-month figure through Mar 2026 stood at $2.3 million (changed 0.0% YoY), and the FY2025 full-year result was $2.4 million, down 14.72% from the prior year.
  • Gains from Investment Securities for Q4 2025 stood at $2.4 million, up from $414417.0 in the prior quarter.
  • The five-year high for Gains from Investment Securities was $5.8 million in Q1 2022, with the low at $35604.0 in Q1 2024.
  • Historically, Gains from Investment Securities has averaged $2.1 million across 5 years, with a median of $1.5 million in 2021.
  • Annual changes were most pronounced in 2021 — Gains from Investment Securities jumped 5442.9% — and 2024, when it tumbled 99.11%.
  • Spero Therapeutics' Gains from Investment Securities stood at $4.9 million in 2021, then tumbled by 97.96% to $100000.0 in 2022, then soared by 2111.0% to $2.2 million in 2023, then grew by 27.31% to $2.8 million in 2024, then declined by 14.72% to $2.4 million in 2025.
  • The last three Gains from Investment Securities figures came in at $2.4 million (Q4 2025), $414417.0 (Q3 2025), and $230932.0 (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr)
1 Alterity Therapeutics 814,307.08 Bn 814,307.05 Bn -
2 Belite Bio 55,320.00 Bn 55,320.00 Bn -
3 Quantum Biopharma 17,149.72 Bn 17,149.72 Bn -
4 Legend Biotech 3,590.00 Bn 3,589.71 Bn 242.10 Mn
5 Akari Therapeutics 1,650.72 Bn 1,650.72 Bn -
6 Evaxion A 1,522.09 Bn 1,522.07 Bn -
7 Psyence Biomedical 229.39 Bn 229.38 Bn -
8 Vertex Pharmaceuticals 113.09 Bn 105.85 Bn 2.59 Bn
9 Abivax 90.15 Bn 90.15 Bn -
10 Spero Therapeutics 162.39 Mn 106.26 Mn -

Historic Data

Download Data
DateValue
Dec 31, 2025 2.40 Mn
Dec 31, 2025 2.40 Mn
Sep 30, 2025 414,417.00
Sep 30, 2025 414,417.00
Jun 30, 2025 230,932.00
Jun 30, 2025 230,932.00
Dec 31, 2024 2.81 Mn
Dec 31, 2024 2.81 Mn
Sep 30, 2024 35,604.00
Sep 30, 2024 35,604.00
Jun 30, 2024 35,604.00
Jun 30, 2024 35,604.00
Mar 31, 2024 35,604.00
Mar 31, 2024 35,604.00
Dec 31, 2023 2.21 Mn
Dec 31, 2023 2.21 Mn
Sep 30, 2023 1.11 Mn
Sep 30, 2023 1.11 Mn
Jun 30, 2023 3.73 Mn
Jun 30, 2023 3.73 Mn