Spero Therapeutics SPRO
NASDAQ SPRO
$1.17 -0.02 (-1.68%)
At close: Sep 9, 2026 · 4:00 PM EDT

Spero Therapeutics (SPRO) EV to FCF (2017 - 2026)

Spero Therapeutics' (SPRO) quarterly EV to FCF came in at 14.52 in Q2 2026, down 94.93% on a YoY basis from 286.5 in Q2 2025, and down 390.25% quarter-over-quarter from 5.0 in Q1 2026.

Analysis

Spero Therapeutics (SPRO) EV to FCF (2017 - 2026) Analysis & Trends

Spero Therapeutics (SPRO) has reported EV to FCF for 10 consecutive years, with 14.52 the latest figure, recorded in Q2 2026.

  • For the quarter ending Q2 2026, EV to FCF fell 94.93% year-over-year to 14.52; the trailing twelve-month figure through Jun 2026 stood at 3.97 (up 197.43% YoY), and the FY2025 full-year result was 7.22, down 4966.29% from the prior year.
  • EV to FCF eased to 14.52 in Q2 2026 per SPRO's latest filing, from 5.0 in the prior quarter.
  • Across five years, EV to FCF topped out at 5.0 in Q1 2026 and bottomed at 36.85 in Q3 2022.
  • Historically, EV to FCF has averaged 3.59 across 5 years, with a median of 0.21 in 2024.
  • The widest YoY moves for EV to FCF: up 1295.33% in 2025, down 7544.54% in 2025.
  • Over 5 years, EV to FCF stood at 0.99 in 2022, then jumped by 90.91% to 0.09 in 2023, then slumped by 58.48% to 0.14 in 2024, then slumped by 7544.54% to 10.92 in 2025, then sank by 32.94% to 14.52 in 2026.
  • According to Business Quant data, EV to FCF over the past three periods registered 14.52, 5.0, and 10.92 for Q2 2026, Q1 2026, and Q4 2025 respectively.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr)
1 Amgen 236.37 Bn 222.38 Bn 7.24 Bn
2 Gilead Sciences 187.38 Bn 184.12 Bn 6.22 Bn
3 Vertex Pharmaceuticals 138.36 Bn 130.51 Bn 2.84 Bn
4 Regeneron Pharmaceuticals 85.09 Bn 77.10 Bn 3.93 Bn
5 Argenx Se 63.93 Bn 58.75 Bn 1.37 Bn
6 Moderna 58.07 Bn 52.94 Bn 52.00 Mn
7 Alnylam Pharmaceuticals 35.59 Bn 32.28 Bn 992.69 Mn
8 Biogen 32.63 Bn 31.34 Bn 1.96 Bn
9 Insmed 27.57 Bn 26.41 Bn 358.27 Mn
10 Spero Therapeutics 70.36 Mn 19.58 Mn -
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 -14.52
Mar 31, 2026 5.00
Dec 31, 2025 -10.92
Sep 30, 2025 3.29
Jun 30, 2025 -7.45
Mar 31, 2025 2.16
Dec 31, 2024 -0.14
Sep 30, 2024 -0.27
Jun 30, 2024 -0.36
Mar 31, 2024 1.75
Dec 31, 2023 -0.09
Sep 30, 2023 -1.87
Jun 30, 2023 0.08
Mar 31, 2023 1.56
Dec 31, 2022 -0.99
Sep 30, 2022 -36.85
Jun 30, 2022 0.84
Mar 31, 2022 -5.78
Dec 31, 2021 -13.61
Sep 30, 2021 -94.86