Spero Therapeutics (SPRO) Tax Rate (2023 - 2025)

Spero Therapeutics (SPRO) reported Tax Rate of 0.82% for Q4 2025, down 37.0% on a YoY basis from 1.3% in Q4 2024, and down 31.0% quarter-over-quarter from 1.19% in Q4 2024.

Spero Therapeutics (SPRO) Tax Rate (2023 - 2025) Analysis & Trends

Spero Therapeutics has reported Tax Rate for 3 years, with the latest figure at 0.82% in Q4 2025.

  • For the quarter ending Q4 2025, Tax Rate fell 37.0% year-over-year to 0.82%; the trailing twelve-month figure through Dec 2025 stood at 2.96% (up 655.0% YoY), and the FY2025 full-year result was 2.96%, changed N/A from the prior year.
  • Tax Rate for Q4 2025 stood at 0.82%, down from 1.19% in the prior quarter.
  • The five-year high for Tax Rate was 1.19% in Q4 2024, with the low at 224.7% in Q3 2023.
  • Historically, Tax Rate has averaged 44.73% across 3 years, with a median of 0.7% in 2023.
  • Annual changes were most pronounced in 2024 — Tax Rate jumped 22303 bps — and 2025, when it tumbled 37 bps.
  • Spero Therapeutics' Tax Rate stood at 0.7% in 2023, then jumped by 71 bps to 1.19% in 2024, then plunged by 31 bps to 0.82% in 2025.
  • The last three Tax Rate figures came in at 0.82% (Q4 2025), 1.19% (Q4 2024), and 1.67% (Q3 2024), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Tax Rate (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -57.14
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -6.79
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - 5.61
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 17.68
9 Abivax 91.96 Bn 91.96 Bn - -
10 Spero Therapeutics 129.74 Mn 73.61 Mn - -

Historic Data

Download Data
DateValue
Dec 31, 2025 0.82%
Dec 31, 2025 0.82%
Dec 31, 2024 1.19%
Dec 31, 2024 1.19%
Sep 30, 2024 -1.67%
Sep 30, 2024 -1.67%
Dec 31, 2023 0.70%
Dec 31, 2023 0.70%
Sep 30, 2023 -224.70%
Sep 30, 2023 -224.70%