Spero Therapeutics (SPRO) Tax Rate (2023 - 2025)
Spero Therapeutics posted quarterly Tax Rate of 0.82% for Q4 2025, down 37.0% year-on-year from 1.3% in Q4 2024, and down 31.0% on a QoQ basis from 1.19% in Q4 2024.
Spero Therapeutics (SPRO) has 3 years of Tax Rate data on file, last reported at 0.82% in Q4 2025.
- For the quarter ending Q4 2025, Tax Rate fell 37.0% year-over-year to 0.82%; the trailing twelve-month figure through Dec 2025 stood at 2.96% (up 655.0% YoY), and the FY2025 full-year result was 2.96%, changed N/A from the prior year.
- Tax Rate for Q4 2025 stood at 0.82%, down from 1.19% in the prior quarter.
- Across five years, Tax Rate topped out at 1.19% in Q4 2024 and bottomed at 224.7% in Q3 2023.
- The 3-year median for Tax Rate is 0.7% (2023), against an average of 44.73%.
- The widest annual swing landed in 2024, when Tax Rate jumped 22303 bps; it then sank 37 bps in 2025.
- A 3-year view of Tax Rate shows it stood at 0.7% in 2023, then surged by 71 bps to 1.19% in 2024, then tumbled by 31 bps to 0.82% in 2025.
- The last three Tax Rate figures came in at 0.82% (Q4 2025), 1.19% (Q4 2024), and 1.67% (Q3 2024), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Tax Rate (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | - |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | 57.14 |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | 5.61 |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 17.68 |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | -6.79 |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 12.51 |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 7.07 |
| 10 | Spero Therapeutics | 162.39 Mn | 106.26 Mn | - | - |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 0.82 |
| Dec 31, 2025 | 0.82 |
| Dec 31, 2024 | 1.19 |
| Dec 31, 2024 | 1.19 |
| Sep 30, 2024 | -1.67 |
| Sep 30, 2024 | -1.67 |
| Dec 31, 2023 | 0.70 |
| Dec 31, 2023 | 0.70 |
| Sep 30, 2023 | -224.70 |
| Sep 30, 2023 | -224.70 |