Growth Metrics

Spero Therapeutics (SPRO) Tax Rate (2023 - 2025)

Spero Therapeutics posted quarterly Tax Rate of 0.82% for Q4 2025, down 37.0% year-on-year from 1.3% in Q4 2024, and down 31.0% on a QoQ basis from 1.19% in Q4 2024.

Spero Therapeutics (SPRO) has 3 years of Tax Rate data on file, last reported at 0.82% in Q4 2025.

  • For the quarter ending Q4 2025, Tax Rate fell 37.0% year-over-year to 0.82%; the trailing twelve-month figure through Dec 2025 stood at 2.96% (up 655.0% YoY), and the FY2025 full-year result was 2.96%, changed N/A from the prior year.
  • Tax Rate for Q4 2025 stood at 0.82%, down from 1.19% in the prior quarter.
  • Across five years, Tax Rate topped out at 1.19% in Q4 2024 and bottomed at 224.7% in Q3 2023.
  • The 3-year median for Tax Rate is 0.7% (2023), against an average of 44.73%.
  • The widest annual swing landed in 2024, when Tax Rate jumped 22303 bps; it then sank 37 bps in 2025.
  • A 3-year view of Tax Rate shows it stood at 0.7% in 2023, then surged by 71 bps to 1.19% in 2024, then tumbled by 31 bps to 0.82% in 2025.
  • The last three Tax Rate figures came in at 0.82% (Q4 2025), 1.19% (Q4 2024), and 1.67% (Q3 2024), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Tax Rate (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - -
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn 57.14
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - 5.61
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 17.68
7 Evaxion A 62.56 Bn 62.54 Bn - -6.79
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 12.51
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 7.07
10 Spero Therapeutics 162.39 Mn 106.26 Mn - -

Historic Data

Download Data 🔒
DateValue
Dec 31, 2025 0.82
Dec 31, 2025 0.82
Dec 31, 2024 1.19
Dec 31, 2024 1.19
Sep 30, 2024 -1.67
Sep 30, 2024 -1.67
Dec 31, 2023 0.70
Dec 31, 2023 0.70
Sep 30, 2023 -224.70
Sep 30, 2023 -224.70