Spero Therapeutics (SPRO) Free Cash Flow (2016 - 2026)
Spero Therapeutics posted quarterly Free Cash Flow of $15.9 million for Q1 2026, up 496.4% year-on-year from $2.7 million in Q1 2025, and up 289.97% on a QoQ basis from -$8.4 million in Q4 2025.
Spero Therapeutics (SPRO) has 11 years of Free Cash Flow data on file, last reported at $15.9 million in Q1 2026.
- For the quarter ending Q1 2026, Free Cash Flow rose 496.4% year-over-year to $15.9 million; the trailing twelve-month figure through Mar 2026 stood at $7.2 million (up 121.69% YoY), and the FY2025 full-year result was -$12.6 million, up 46.15% from the prior year.
- Free Cash Flow for Q1 2026 stood at $15.9 million, up from -$8.4 million in the prior quarter.
- Across five years, Free Cash Flow topped out at $44.5 million in Q4 2022 and bottomed at -$28.2 million in Q1 2022.
- The 5-year median for Free Cash Flow is -$8.4 million (2025), against an average of -$3.6 million.
- The widest annual swing landed in 2023, when Free Cash Flow jumped 1763.01%; it then sank 167.4% in 2025.
- A 5-year view of Free Cash Flow shows it stood at $44.5 million in 2022, then plunged by 139.33% to -$17.5 million in 2023, then tumbled by 33.77% to -$23.4 million in 2024, then soared by 64.31% to -$8.4 million in 2025, then jumped by 289.97% to $15.9 million in 2026.
- The last three Free Cash Flow figures came in at $15.9 million (Q1 2026), -$8.4 million (Q4 2025), and $17.4 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Free Cash Flow (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | -1.67 Mn |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | -12.20 Mn |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | -2.49 Mn |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 1.29 Bn |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 848.30 Mn |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 48.67 Mn |
| 10 | Spero Therapeutics | 162.39 Mn | 106.26 Mn | - | 15.86 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 15.86 Mn |
| Mar 31, 2026 | 15.86 Mn |
| Dec 31, 2025 | -8.35 Mn |
| Dec 31, 2025 | -8.35 Mn |
| Sep 30, 2025 | 17.42 Mn |
| Sep 30, 2025 | 17.42 Mn |
| Jun 30, 2025 | -17.69 Mn |
| Jun 30, 2025 | -17.69 Mn |
| Mar 31, 2025 | -4.00 Mn |
| Mar 31, 2025 | -4.00 Mn |
| Dec 31, 2024 | -23.40 Mn |
| Dec 31, 2024 | -23.40 Mn |
| Sep 30, 2024 | 12.76 Mn |
| Sep 30, 2024 | 12.76 Mn |
| Jun 30, 2024 | -18.74 Mn |
| Jun 30, 2024 | -18.74 Mn |
| Mar 31, 2024 | 5.94 Mn |
| Mar 31, 2024 | 5.94 Mn |
| Dec 31, 2023 | -17.49 Mn |
| Dec 31, 2023 | -17.49 Mn |
| Sep 30, 2023 | 15.92 Mn |
| Sep 30, 2023 | 15.92 Mn |
| Jun 30, 2023 | -18.56 Mn |
| Jun 30, 2023 | -18.56 Mn |
| Mar 31, 2023 | -12.85 Mn |
| Mar 31, 2023 | -12.85 Mn |
| Dec 31, 2022 | 44.48 Mn |
| Dec 31, 2022 | 44.48 Mn |
| Sep 30, 2022 | -957,000.00 |
| Sep 30, 2022 | -957,000.00 |
| Jun 30, 2022 | -23.03 Mn |
| Jun 30, 2022 | -23.03 Mn |
| Mar 31, 2022 | -28.22 Mn |
| Mar 31, 2022 | -28.22 Mn |
| Dec 31, 2021 | -27.31 Mn |
| Dec 31, 2021 | -27.31 Mn |
| Sep 30, 2021 | -4.95 Mn |
| Sep 30, 2021 | -4.95 Mn |
| Jun 30, 2021 | -16.57 Mn |
| Jun 30, 2021 | -16.57 Mn |
| Mar 31, 2021 | -15.48 Mn |
| Mar 31, 2021 | -15.48 Mn |
| Dec 31, 2020 | -16.40 Mn |
| Dec 31, 2020 | -16.40 Mn |
| Sep 30, 2020 | -21.32 Mn |
| Sep 30, 2020 | -21.32 Mn |
| Jun 30, 2020 | -24.91 Mn |
| Jun 30, 2020 | -24.91 Mn |
| Mar 31, 2020 | -23.41 Mn |
| Mar 31, 2020 | -23.41 Mn |
| Dec 31, 2019 | -17.50 Mn |
| Dec 31, 2019 | -17.50 Mn |
| Sep 30, 2019 | -9.68 Mn |
| Sep 30, 2019 | -9.68 Mn |
| Jun 30, 2019 | -12.16 Mn |
| Jun 30, 2019 | -12.16 Mn |
| Mar 31, 2019 | -11.01 Mn |
| Mar 31, 2019 | -11.01 Mn |
| Dec 31, 2018 | -13.54 Mn |
| Dec 31, 2018 | -13.54 Mn |
| Sep 30, 2018 | -5.51 Mn |
| Sep 30, 2018 | -5.51 Mn |
| Jun 30, 2018 | -8.64 Mn |
| Jun 30, 2018 | -8.64 Mn |
| Mar 31, 2018 | -11.96 Mn |
| Mar 31, 2018 | -11.96 Mn |
| Dec 31, 2017 | -12.74 Mn |
| Dec 31, 2017 | -12.74 Mn |
| Sep 30, 2017 | -10.52 Mn |
| Sep 30, 2017 | -10.52 Mn |
| Jun 30, 2017 | -8.88 Mn |
| Jun 30, 2017 | -8.88 Mn |
| Mar 31, 2017 | -6.98 Mn |
| Mar 31, 2017 | -6.98 Mn |
| Dec 31, 2016 | -9.47 Mn |
| Dec 31, 2016 | -9.47 Mn |