Spero Therapeutics (SPRO) Operating Expenses (2016 - 2026)
Spero Therapeutics' Operating Expenses was $9.93 million in Q2 2026, down 40.3% from $16.63 million a year earlier but up 27.3% from the prior quarter.
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Analysis
Spero Therapeutics (SPRO) Operating Expenses (2016 - 2026) Analysis & Trends
On a trailing twelve-month basis, Spero Therapeutics' Operating Expenses was $40.97 million through Jun 30, 2026, down 61.4% year-over-year; for FY2025, it came in at $60.49 million, down 50.1% from FY2024.
- Operating Expenses shows a five-year compound annual growth rate of -7.3% (FY2020 to FY2025).
- In earlier years, Operating Expenses was $121.34 million in FY2024 (+47.4%), $82.3 million in FY2023 (-14.0%), $95.71 million in FY2022 (-9.9%) and $106.23 million in FY2021 (+20.1%).
- Quarterly Operating Expenses has moved between $7.8 million (Q1 2026) and $36.77 million (Q4 2024) over five years.
- Compared with a year earlier, Operating Expenses has declined for six straight quarters, with an average decline of 26.4% over the last eight quarters.
- The best year-over-year quarter for Operating Expenses over five years was Q3 2023 (growth of 98.0%); the worst was Q4 2025 (a decline of 73.1%).
- Per Business Quant data, SPRO's Operating Expenses in the three quarters before Q2 2026 was $7.8 million (Q1 2026), $9.89 million (Q4 2025) and $13.36 million (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Opex (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,136.97 Bn | 1,105.55 Bn | 19.71 Bn | 7.95 Bn |
| 2 | Johnson & Johnson | 619.72 Bn | 538.25 Bn | 17.26 Bn | 10.12 Bn |
| 3 | AbbVie | 503.40 Bn | 476.52 Bn | 12.70 Bn | 10.56 Bn |
| 4 | Merck | 370.15 Bn | 324.53 Bn | 12.21 Bn | 12.80 Bn |
| 5 | Novartis Ag | 298.64 Bn | 262.63 Bn | 11.24 Bn | 6.09 Bn |
| 6 | Astrazeneca | 261.07 Bn | 234.76 Bn | 12.86 Bn | 9.70 Bn |
| 7 | Amgen | 237.00 Bn | 192.40 Bn | 7.24 Bn | 6.54 Bn |
| 8 | Gilead Sciences | 191.24 Bn | 165.43 Bn | 6.22 Bn | 18.20 Bn |
| 9 | Pfizer | 170.31 Bn | 116.96 Bn | 10.94 Bn | 6.68 Bn |
| 10 | Spero Therapeutics | 68.40 Mn | -127.38 Mn | - | 9.93 Mn |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 9.93 Mn |
| Mar 31, 2026 | 7.80 Mn |
| Dec 31, 2025 | 9.89 Mn |
| Sep 30, 2025 | 13.36 Mn |
| Jun 30, 2025 | 16.63 Mn |
| Mar 31, 2025 | 20.61 Mn |
| Dec 31, 2024 | 36.77 Mn |
| Sep 30, 2024 | 32.06 Mn |
| Jun 30, 2024 | 29.26 Mn |
| Mar 31, 2024 | 23.25 Mn |
| Dec 31, 2023 | 22.99 Mn |
| Sep 30, 2023 | 27.41 Mn |
| Jun 30, 2023 | 15.61 Mn |
| Mar 31, 2023 | 16.30 Mn |
| Dec 31, 2022 | 21.52 Mn |
| Sep 30, 2022 | 13.84 Mn |
| Jun 30, 2022 | 28.07 Mn |
| Mar 31, 2022 | 32.28 Mn |
| Dec 31, 2021 | 30.25 Mn |
| Sep 30, 2021 | 25.59 Mn |
API Access
Spero Therapeutics Operating Expenses API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-expenses&ticker=SPRO&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-expenses", "ticker": "SPRO", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-expenses&ticker=SPRO&period=max&api_key=YOUR_API_KEY");
const data = await res.json();