Spero Therapeutics (SPRO) Revenue (2016 - 2026)

Spero Therapeutics (SPRO) reported Revenue of $258000.0 for Q1 2026, down 95.61% on a YoY basis from $5.9 million in Q1 2025, and up 103.51% quarter-over-quarter from -$7.3 million in Q4 2025.

Spero Therapeutics (SPRO) Revenue (2016 - 2026) Analysis & Trends

Spero Therapeutics has reported Revenue for 11 years, with the latest figure at $258000.0 in Q1 2026.

  • For the quarter ending Q1 2026, Revenue fell 95.61% year-over-year to $258000.0; the trailing twelve-month figure through Mar 2026 stood at $12.5 million (down 70.21% YoY), and the FY2025 full-year result was $12.6 million, down 73.74% from the prior year.
  • Revenue for Q1 2026 stood at $258000.0, up from -$7.3 million in the prior quarter.
  • The five-year high for Revenue was $65.5 million in Q4 2023, with the low at -$7.3 million in Q4 2025.
  • Historically, Revenue has averaged $9.1 million across 5 years, with a median of $2.7 million in 2023.
  • The largest YoY upside for Revenue was 8272.31% in 2025 against a maximum downside of 124.29% in 2025.
  • Spero Therapeutics' Revenue stood at $16.8 million in 2022, then soared by 290.72% to $65.5 million in 2023, then sank by 53.84% to $30.3 million in 2024, then tumbled by 124.29% to -$7.3 million in 2025, then surged by 103.51% to $258000.0 in 2026.
  • The last three Revenue figures came in at $258000.0 (Q1 2026), -$7.3 million (Q4 2025), and $5.4 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Revenue (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - 5.21 Mn
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 306.30 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 2.99 Bn
9 Abivax 91.96 Bn 91.96 Bn - -
10 Spero Therapeutics 129.74 Mn 73.61 Mn - 258,000.00

Historic Data

Download Data
DateValue
Mar 31, 2026 258,000.00
Dec 31, 2025 -7.35 Mn
Sep 30, 2025 5.44 Mn
Jun 30, 2025 14.19 Mn
Mar 31, 2025 5.87 Mn
Dec 31, 2024 30.26 Mn
Sep 30, 2024 65,000.00
Jun 30, 2024 5.90 Mn
Mar 31, 2024 9.27 Mn
Dec 31, 2023 65.54 Mn
Sep 30, 2023 218,000.00
Jun 30, 2023 2.72 Mn
Mar 31, 2023 223,000.00
Dec 31, 2022 16.78 Mn
Sep 30, 2022 2.01 Mn
Jun 30, 2022 1.99 Mn
Mar 31, 2022 2.07 Mn
Dec 31, 2021 15.44 Mn
Sep 30, 2021 708,000.00
Jun 30, 2021 2.11 Mn