Spero Therapeutics (SPRO) Change in Cash (2016 - 2026)
Spero Therapeutics' (SPRO) quarterly Change in Cash came in at -$5.4 million in Q2 2026, up 69.73% on a YoY basis from -$3.2 million in Q2 2025, and down 133.76% quarter-over-quarter from $15.9 million in Q1 2026.
Analysis
Spero Therapeutics (SPRO) Change in Cash (2016 - 2026) Analysis & Trends
Spero Therapeutics (SPRO) has reported Change in Cash for 11 consecutive years, with -$5.4 million the latest figure, recorded in Q2 2026.
- For the quarter ending Q2 2026, Change in Cash rose 69.73% year-over-year to -$5.4 million; the trailing twelve-month figure through Jun 2026 stood at $19.6 million (up 160.56% YoY), and the FY2025 full-year result was -$12.6 million, up 46.15% from the prior year.
- Change in Cash retreated to -$5.4 million in Q2 2026 per SPRO's latest filing, from $15.9 million in the prior quarter.
- Across five years, Change in Cash topped out at $58.7 million in Q4 2022 and bottomed at -$40.5 million in Q1 2022.
- Historically, Change in Cash has averaged -$3.4 million across 5 years, with a median of -$6.9 million in 2025.
- The widest YoY moves for Change in Cash: up 21431.27% in 2022, down 395.57% in 2022.
- Over 5 years, Change in Cash stood at $58.7 million in 2022, then tumbled by 129.82% to -$17.5 million in 2023, then tumbled by 33.78% to -$23.4 million in 2024, then jumped by 64.31% to -$8.4 million in 2025, then soared by 35.88% to -$5.4 million in 2026.
- According to Business Quant data, Change in Cash over the past three periods registered -$5.4 million, $15.9 million, and -$8.4 million for Q2 2026, Q1 2026, and Q4 2025 respectively.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Change in Cash (Qtr) |
|---|---|---|---|---|---|
| 1 | Amgen | 211.73 Bn | 197.74 Bn | 7.24 Bn | 1.95 Bn |
| 2 | Gilead Sciences | 180.92 Bn | 177.74 Bn | 6.22 Bn | -4.45 Bn |
| 3 | Vertex Pharmaceuticals | 132.16 Bn | 124.30 Bn | 2.84 Bn | 649.20 Mn |
| 4 | Regeneron Pharmaceuticals | 82.89 Bn | 74.90 Bn | 3.93 Bn | -504.60 Mn |
| 5 | Argenx Se | 61.41 Bn | 56.23 Bn | 1.37 Bn | - |
| 6 | Moderna | 53.99 Bn | 48.85 Bn | 52.00 Mn | -185.00 Mn |
| 7 | Alnylam Pharmaceuticals | 34.48 Bn | 31.18 Bn | 992.69 Mn | -2.94 Mn |
| 8 | Biogen | 31.15 Bn | 29.86 Bn | 1.96 Bn | -2.09 Bn |
| 9 | Roivant Sciences | 30.05 Bn | 30.05 Bn | 1.16 Mn | -170.44 Mn |
| 10 | Spero Therapeutics | 67.82 Mn | 17.05 Mn | - | -5.36 Mn |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -5.36 Mn |
| Mar 31, 2026 | 15.86 Mn |
| Dec 31, 2025 | -8.35 Mn |
| Sep 30, 2025 | 17.42 Mn |
| Jun 30, 2025 | -17.69 Mn |
| Mar 31, 2025 | -4.00 Mn |
| Dec 31, 2024 | -23.40 Mn |
| Sep 30, 2024 | 12.76 Mn |
| Jun 30, 2024 | -18.74 Mn |
| Mar 31, 2024 | 5.94 Mn |
| Dec 31, 2023 | -17.49 Mn |
| Sep 30, 2023 | 16.14 Mn |
| Jun 30, 2023 | -18.56 Mn |
| Mar 31, 2023 | -12.85 Mn |
| Dec 31, 2022 | 58.66 Mn |
| Sep 30, 2022 | 5.05 Mn |
| Jun 30, 2022 | -26.71 Mn |
| Mar 31, 2022 | -40.47 Mn |
| Dec 31, 2021 | -275,000.00 |
| Sep 30, 2021 | 41.30 Mn |