Spero Therapeutics SPRO
NASDAQ SPRO
$1.17 -0.02 (-1.68%)
At close: Sep 9, 2026 · 4:00 PM EDT

Spero Therapeutics (SPRO) Change in Cash (2016 - 2026)

Spero Therapeutics' (SPRO) quarterly Change in Cash came in at -$5.4 million in Q2 2026, up 69.73% on a YoY basis from -$3.2 million in Q2 2025, and down 133.76% quarter-over-quarter from $15.9 million in Q1 2026.

Analysis

Spero Therapeutics (SPRO) Change in Cash (2016 - 2026) Analysis & Trends

Spero Therapeutics (SPRO) has reported Change in Cash for 11 consecutive years, with -$5.4 million the latest figure, recorded in Q2 2026.

  • For the quarter ending Q2 2026, Change in Cash rose 69.73% year-over-year to -$5.4 million; the trailing twelve-month figure through Jun 2026 stood at $19.6 million (up 160.56% YoY), and the FY2025 full-year result was -$12.6 million, up 46.15% from the prior year.
  • Change in Cash retreated to -$5.4 million in Q2 2026 per SPRO's latest filing, from $15.9 million in the prior quarter.
  • Across five years, Change in Cash topped out at $58.7 million in Q4 2022 and bottomed at -$40.5 million in Q1 2022.
  • Historically, Change in Cash has averaged -$3.4 million across 5 years, with a median of -$6.9 million in 2025.
  • The widest YoY moves for Change in Cash: up 21431.27% in 2022, down 395.57% in 2022.
  • Over 5 years, Change in Cash stood at $58.7 million in 2022, then tumbled by 129.82% to -$17.5 million in 2023, then tumbled by 33.78% to -$23.4 million in 2024, then jumped by 64.31% to -$8.4 million in 2025, then soared by 35.88% to -$5.4 million in 2026.
  • According to Business Quant data, Change in Cash over the past three periods registered -$5.4 million, $15.9 million, and -$8.4 million for Q2 2026, Q1 2026, and Q4 2025 respectively.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Change in Cash (Qtr)
1 Amgen 211.73 Bn 197.74 Bn 7.24 Bn 1.95 Bn
2 Gilead Sciences 180.92 Bn 177.74 Bn 6.22 Bn -4.45 Bn
3 Vertex Pharmaceuticals 132.16 Bn 124.30 Bn 2.84 Bn 649.20 Mn
4 Regeneron Pharmaceuticals 82.89 Bn 74.90 Bn 3.93 Bn -504.60 Mn
5 Argenx Se 61.41 Bn 56.23 Bn 1.37 Bn -
6 Moderna 53.99 Bn 48.85 Bn 52.00 Mn -185.00 Mn
7 Alnylam Pharmaceuticals 34.48 Bn 31.18 Bn 992.69 Mn -2.94 Mn
8 Biogen 31.15 Bn 29.86 Bn 1.96 Bn -2.09 Bn
9 Roivant Sciences 30.05 Bn 30.05 Bn 1.16 Mn -170.44 Mn
10 Spero Therapeutics 67.82 Mn 17.05 Mn - -5.36 Mn
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 -5.36 Mn
Mar 31, 2026 15.86 Mn
Dec 31, 2025 -8.35 Mn
Sep 30, 2025 17.42 Mn
Jun 30, 2025 -17.69 Mn
Mar 31, 2025 -4.00 Mn
Dec 31, 2024 -23.40 Mn
Sep 30, 2024 12.76 Mn
Jun 30, 2024 -18.74 Mn
Mar 31, 2024 5.94 Mn
Dec 31, 2023 -17.49 Mn
Sep 30, 2023 16.14 Mn
Jun 30, 2023 -18.56 Mn
Mar 31, 2023 -12.85 Mn
Dec 31, 2022 58.66 Mn
Sep 30, 2022 5.05 Mn
Jun 30, 2022 -26.71 Mn
Mar 31, 2022 -40.47 Mn
Dec 31, 2021 -275,000.00
Sep 30, 2021 41.30 Mn