Spero Therapeutics (SPRO) Operating Margin (2017 - 2026)
Spero Therapeutics (SPRO) posted Operating Margin of -2921.71% for Q1 2026, down 2670.92 percentage points from -250.78% a year earlier and down 2997.75 percentage points from the prior quarter.
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Analysis
Spero Therapeutics (SPRO) Operating Margin (2017 - 2026) Analysis & Trends
For FY2025, Spero Therapeutics' Operating Margin came in at 9.45%, up 162.36 percentage points from FY2024.
- Annual Operating Margin shows a five-year change of +857.39 percentage points (FY2020 to FY2025).
- In prior years, Spero Therapeutics' Operating Margin was -152.91% in FY2024 (-173.61 pp), 20.70% in FY2023 (+99.56 pp), -78.86% in FY2022 (+403.01 pp) and -481.87% in FY2021 (+366.07 pp).
- The Q1 2026 figure stands as the lowest quarterly Operating Margin since Q4 2019.
- On a year-over-year basis, Operating Margin increased in three of the last eight quarters, with an average year-over-year change of -305.50 percentage points.
- The strongest year-over-year quarter for Operating Margin in the past five years was Q4 2022, with a gain of 1056.90 percentage points; the weakest was Q1 2026, with a drop of 2670.92 percentage points.
- According to Business Quant data, Operating Margin for the three prior quarters was 76.05% (Q4 2025), -145.46% (Q3 2025) and -17.22% (Q2 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,136.97 Bn | 1,105.55 Bn | 19.71 Bn | 51.16% |
| 2 | Johnson & Johnson | 619.72 Bn | 538.25 Bn | 17.26 Bn | 28.21% |
| 3 | AbbVie | 503.40 Bn | 476.52 Bn | 12.70 Bn | 37.86% |
| 4 | Merck | 370.15 Bn | 324.53 Bn | 12.21 Bn | -3.52% |
| 5 | Novartis Ag | 298.64 Bn | 262.63 Bn | 11.24 Bn | 32.97% |
| 6 | Astrazeneca | 261.07 Bn | 234.76 Bn | 12.86 Bn | 20.57% |
| 7 | Amgen | 237.00 Bn | 192.40 Bn | 7.24 Bn | 34.95% |
| 8 | Gilead Sciences | 191.24 Bn | 165.43 Bn | 6.22 Bn | -133.21% |
| 9 | Pfizer | 170.31 Bn | 116.96 Bn | 10.94 Bn | 28.37% |
| 10 | Spero Therapeutics | 68.40 Mn | -127.38 Mn | - | - |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Mar 31, 2026 | -2,921.71% |
| Dec 31, 2025 | 76.05% |
| Sep 30, 2025 | -145.46% |
| Jun 30, 2025 | -17.22% |
| Mar 31, 2025 | -250.78% |
| Dec 31, 2024 | -144.41% |
| Sep 30, 2024 | -138.04% |
| Jun 30, 2024 | -186.93% |
| Mar 31, 2024 | -150.88% |
| Dec 31, 2023 | 68.73% |
| Sep 30, 2023 | -7.59% |
| Jun 30, 2023 | -474.59% |
| Mar 31, 2023 | -687.63% |
| Dec 31, 2022 | 54.64% |
| Sep 30, 2022 | -589.93% |
| Jun 30, 2022 | -1,308.58% |
| Mar 31, 2022 | -1,459.98% |
| Dec 31, 2021 | -1,002.26% |
| Sep 30, 2021 | -735.12% |
| Jun 30, 2021 | -360.18% |
API Access
Spero Therapeutics Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=SPRO&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "SPRO", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=SPRO&period=max&api_key=YOUR_API_KEY");
const data = await res.json();