Spero Therapeutics (SPRO) EBT Margin (2016 - 2026)
Spero Therapeutics posted quarterly EBT Margin of 2791.47% for Q1 2026, down 255540.0% year-on-year from N/an in Q1 2025, and down 545.5% on a QoQ basis from 432.45% in Q4 2025.
Spero Therapeutics (SPRO) has 11 years of EBT Margin data on file, last reported at 2791.47% in Q1 2026.
- For the quarter ending Q1 2026, EBT Margin fell 255540.0% year-over-year to 2791.47%; the trailing twelve-month figure through Mar 2026 stood at 123.53% (up 29814.0% YoY), and the FY2025 full-year result was 70.05%, up 21309.0% from the prior year.
- EBT Margin for Q1 2026 stood at 2791.47%, down from 432.45% in the prior quarter.
- Across five years, EBT Margin topped out at 163.85% in Q4 2022 and bottomed at 26786.15% in Q3 2024.
- The 5-year median for EBT Margin is 432.45% (2025), against an average of 2402.0%.
- The widest annual swing landed in 2024, when EBT Margin sank 2633478 bps; it then jumped 2665047 bps in 2025.
- A 5-year view of EBT Margin shows it stood at 163.85% in 2022, then sank by 48 bps to 84.67% in 2023, then sank by 195 bps to 80.53% in 2024, then plunged by 437 bps to 432.45% in 2025, then tumbled by 545 bps to 2791.47% in 2026.
- The last three EBT Margin figures came in at 2791.47% (Q1 2026), 432.45% (Q4 2025), and 135.69% (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBT Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | - |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | -6.40% |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 41.95% |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 23.05% |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 18.99% |
| 10 | Spero Therapeutics | 162.39 Mn | 106.26 Mn | - | -2,791.47% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -2,791.47% |
| Dec 31, 2025 | -432.45% |
| Sep 30, 2025 | -135.69% |
| Jun 30, 2025 | -12.01% |
| Mar 31, 2025 | -236.07% |
| Dec 31, 2024 | -80.53% |
| Sep 30, 2024 | -26,786.15% |
| Jun 30, 2024 | -302.61% |
| Mar 31, 2024 | -136.56% |
| Dec 31, 2023 | 84.67% |
| Sep 30, 2023 | -451.38% |
| Jun 30, 2023 | -438.44% |
| Mar 31, 2023 | -5,947.98% |
| Dec 31, 2022 | 163.85% |
| Sep 30, 2022 | -571.64% |
| Jun 30, 2022 | -1,303.01% |
| Mar 31, 2022 | -1,456.50% |
| Dec 31, 2021 | -177.61% |
| Sep 30, 2021 | -3,168.64% |
| Jun 30, 2021 | -876.54% |
| Mar 31, 2021 | -264.45% |
| Sep 30, 2020 | -49,976.32% |
| Jun 30, 2020 | -1,064.85% |
| Mar 31, 2020 | -1,327.69% |
| Dec 31, 2019 | -3,672.84% |
| Sep 30, 2019 | -378.68% |
| Jun 30, 2019 | -19,828.36% |
| Mar 31, 2019 | -70.70% |
| Dec 31, 2018 | -628.96% |
| Sep 30, 2018 | -1,590.12% |
| Jun 30, 2018 | -2,150.32% |
| Dec 31, 2017 | -1,395.97% |
| Sep 30, 2017 | -1,648.58% |
| Jun 30, 2017 | -4,061.45% |
| Mar 31, 2017 | -5,435.71% |
| Dec 31, 2016 | 13,553.85% |
| Sep 30, 2016 | -7,914.00% |