Growth Metrics

Spero Therapeutics (SPRO) Net Income (2016 - 2026)

Spero Therapeutics posted quarterly Net Income of -$7.2 million for Q1 2026, up 48.06% year-on-year from -$4.9 million in Q1 2025, and down 122.85% on a QoQ basis from $31.5 million in Q4 2025.

Spero Therapeutics (SPRO) has 11 years of Net Income data on file, last reported at -$7.2 million in Q1 2026.

  • For the quarter ending Q1 2026, Net Income rose 48.06% year-over-year to -$7.2 million; the trailing twelve-month figure through Mar 2026 stood at $15.2 million (up 120.72% YoY), and the FY2025 full-year result was $8.6 million, up 112.48% from the prior year.
  • Net Income for Q1 2026 stood at -$7.2 million, down from $31.5 million in the prior quarter.
  • Across five years, Net Income topped out at $55.1 million in Q4 2023 and bottomed at -$30.1 million in Q1 2022.
  • The 5-year median for Net Income is -$11.9 million (2023), against an average of -$5.0 million.
  • The widest annual swing landed in 2024, when Net Income sank 454.02%; it then soared 230.92% in 2025.
  • A 5-year view of Net Income shows it stood at $27.5 million in 2022, then soared by 100.51% to $55.1 million in 2023, then tumbled by 143.68% to -$24.1 million in 2024, then jumped by 230.92% to $31.5 million in 2025, then slumped by 122.85% to -$7.2 million in 2026.
  • The last three Net Income figures came in at -$7.2 million (Q1 2026), $31.5 million (Q4 2025), and -$7.4 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Net Income (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - -2.99 Mn
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn -8.40 Mn
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - -14.46 Mn
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 1.03 Bn
7 Evaxion A 62.56 Bn 62.54 Bn - -3.40 Mn
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 727.20 Mn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 205.99 Mn
10 Spero Therapeutics 162.39 Mn 106.26 Mn - -7.20 Mn

Historic Data

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DateValue
Mar 31, 2026 -7.20 Mn
Dec 31, 2025 31.52 Mn
Sep 30, 2025 -7.38 Mn
Jun 30, 2025 -1.70 Mn
Mar 31, 2025 -13.87 Mn
Dec 31, 2024 -24.08 Mn
Sep 30, 2024 -17.70 Mn
Jun 30, 2024 -17.86 Mn
Mar 31, 2024 -12.66 Mn
Dec 31, 2023 55.11 Mn
Sep 30, 2023 -3.20 Mn
Jun 30, 2023 -11.91 Mn
Mar 31, 2023 -13.26 Mn
Dec 31, 2022 27.49 Mn
Sep 30, 2022 -11.47 Mn
Jun 30, 2022 -25.97 Mn
Mar 31, 2022 -30.14 Mn
Dec 31, 2021 -27.43 Mn
Sep 30, 2021 -22.43 Mn
Jun 30, 2021 -18.46 Mn
Mar 31, 2021 -19.31 Mn
Dec 31, 2020 -18.75 Mn
Sep 30, 2020 -18.99 Mn
Jun 30, 2020 -18.39 Mn
Mar 31, 2020 -22.58 Mn
Dec 31, 2019 -25.56 Mn
Sep 30, 2019 -17.58 Mn
Jun 30, 2019 -13.29 Mn
Mar 31, 2019 -5.46 Mn
Dec 31, 2018 -10.64 Mn
Sep 30, 2018 -10.46 Mn
Jun 30, 2018 -9.96 Mn
Mar 31, 2018 -10.64 Mn
Dec 31, 2017 -13.86 Mn
Sep 30, 2017 -9.84 Mn
Jun 30, 2017 -10.11 Mn
Mar 31, 2017 -7.61 Mn
Dec 31, 2016 -8.81 Mn
Sep 30, 2016 -7.91 Mn