Growth Metrics

Spero Therapeutics (SPRO) Retained Earnings (2016 - 2026)

Spero Therapeutics posted quarterly Retained Earnings of -$458.3 million for Q1 2026, up 3.22% year-on-year from -$444.0 million in Q1 2025, and down 1.6% on a QoQ basis from -$451.1 million in Q4 2025.

Spero Therapeutics (SPRO) has 11 years of Retained Earnings data on file, last reported at -$458.3 million in Q1 2026.

  • For the quarter ending Q1 2026, Retained Earnings rose 3.22% year-over-year to -$458.3 million; the trailing twelve-month figure through Mar 2026 stood at -$458.3 million (up 3.22% YoY), and the FY2025 full-year result was -$451.1 million, up 1.86% from the prior year.
  • Retained Earnings for Q1 2026 stood at -$458.3 million, down from -$451.1 million in the prior quarter.
  • Across five years, Retained Earnings topped out at -$391.1 million in Q4 2023 and bottomed at -$482.6 million in Q3 2025.
  • The 5-year median for Retained Earnings is -$439.8 million (2022), against an average of -$439.6 million.
  • The widest annual swing landed in 2022, when Retained Earnings slumped 35.89%; it then gained 5.48% in 2024.
  • A 5-year view of Retained Earnings shows it stood at -$440.6 million in 2022, then grew by 11.24% to -$391.1 million in 2023, then decreased by 17.53% to -$459.6 million in 2024, then increased by 1.86% to -$451.1 million in 2025, then declined by 1.6% to -$458.3 million in 2026.
  • The last three Retained Earnings figures came in at -$458.3 million (Q1 2026), -$451.1 million (Q4 2025), and -$482.6 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Retained Earnings (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - -211.85 Mn
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -153.89 Mn
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn 1.00 Bn
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -438.66 Mn
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - -279.00 Mn
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 14.59 Bn
7 Evaxion A 62.56 Bn 62.54 Bn - 130.89 Mn
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 36.42 Bn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn -24.89 Mn
10 Spero Therapeutics 162.39 Mn 106.26 Mn - -458.27 Mn

Historic Data

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DateValue
Mar 31, 2026 -458.27 Mn
Dec 31, 2025 -451.07 Mn
Sep 30, 2025 -482.60 Mn
Jun 30, 2025 -475.20 Mn
Mar 31, 2025 -473.50 Mn
Dec 31, 2024 -459.64 Mn
Sep 30, 2024 -438.75 Mn
Jun 30, 2024 -421.60 Mn
Mar 31, 2024 -403.70 Mn
Dec 31, 2023 -391.07 Mn
Sep 30, 2023 -442.26 Mn
Jun 30, 2023 -439.06 Mn
Mar 31, 2023 -427.10 Mn
Sep 30, 2022 -440.60 Mn
Jun 30, 2022 -429.00 Mn
Mar 31, 2022 -400.29 Mn
Dec 31, 2021 -367.46 Mn
Sep 30, 2021 -338.20 Mn
Jun 30, 2021 -315.70 Mn
Mar 31, 2021 -297.10 Mn
Dec 31, 2020 -7,000.00
Sep 30, 2020 1,000.00
Jun 30, 2020 15,000.00
Mar 31, 2020 -222.69 Mn
Dec 31, 2019 -199.43 Mn
Sep 30, 2019 18,000.00
Jun 30, 2019 -156.72 Mn
Mar 31, 2019 1,000.00
Dec 31, 2018 -28,000.00
Sep 30, 2018 -23,000.00
Jun 30, 2018 -117.44 Mn
Mar 31, 2018 -29,000.00
Dec 31, 2017 -96.84 Mn
Sep 30, 2017 -82.19 Mn
Jun 30, 2017 1.00 Mn
Dec 31, 2016 -45.44 Mn