Spero Therapeutics (SPRO) FCF Margin (2017 - 2026)
Spero Therapeutics (SPRO) reported FCF Margin of 6148.84% for Q1 2026, up 6216.97 percentage points from -68.13% a year earlier and up 6169.06 percentage points from the prior quarter.
Powered by 
Analysis
Spero Therapeutics (SPRO) FCF Margin (2017 - 2026) Analysis & Trends
For FY2025, Spero Therapeutics posted FCF Margin of -18.90%, up 29.97 percentage points from FY2024.
- FCF Margin has a five-year change of +903.17 percentage points (FY2020 to FY2025).
- By year, FCF Margin came in at -48.87% in FY2024 (-17.07 pp), -31.79% in FY2023 (-17.34 pp), -14.45% in FY2022 (+338.02 pp) and -352.47% in FY2021 (+569.60 pp).
- The Q1 2026 figure ranks as the highest quarterly FCF Margin in data going back to Q1 2017.
- Year over year, FCF Margin has now increased in each of the last four quarters, with an average year-over-year change of +863.10 percentage points over the last eight quarters.
- The high point for year-over-year FCF Margin in five years was Q1 2026 (a gain of 6216.97 percentage points); the low point was Q1 2022 (a drop of 1152.05 percentage points).
- Per Business Quant data, the three quarters before Q1 2026 came in at -20.22% (Q4 2025), 320.14% (Q3 2025) and -124.70% (Q2 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | FCF Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,136.97 Bn | 1,105.55 Bn | 19.71 Bn | 33.76% |
| 2 | Johnson & Johnson | 619.72 Bn | 538.25 Bn | 17.26 Bn | 28.82% |
| 3 | AbbVie | 503.40 Bn | 476.52 Bn | 12.70 Bn | 18.33% |
| 4 | Merck | 370.15 Bn | 324.53 Bn | 12.21 Bn | 26.96% |
| 5 | Novartis Ag | 298.64 Bn | 262.63 Bn | 11.24 Bn | 38.60% |
| 6 | Astrazeneca | 261.07 Bn | 234.76 Bn | 12.86 Bn | 6.55% |
| 7 | Amgen | 237.00 Bn | 192.40 Bn | 7.24 Bn | 34.70% |
| 8 | Gilead Sciences | 191.24 Bn | 165.43 Bn | 6.22 Bn | 44.00% |
| 9 | Pfizer | 170.31 Bn | 116.96 Bn | 10.94 Bn | 2.01% |
| 10 | Spero Therapeutics | 68.40 Mn | -127.38 Mn | - | - |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Mar 31, 2026 | 6,148.84% |
| Dec 31, 2025 | -20.22% |
| Sep 30, 2025 | 320.14% |
| Jun 30, 2025 | -124.70% |
| Mar 31, 2025 | -68.13% |
| Dec 31, 2024 | -155.55% |
| Sep 30, 2024 | 94.76% |
| Jun 30, 2024 | -183.82% |
| Mar 31, 2024 | 64.08% |
| Dec 31, 2023 | -23.79% |
| Sep 30, 2023 | 62.48% |
| Jun 30, 2023 | -683.51% |
| Mar 31, 2023 | -621.22% |
| Dec 31, 2022 | 93.76% |
| Sep 30, 2022 | -47.71% |
| Jun 30, 2022 | -1,155.69% |
| Mar 31, 2022 | -1,364.09% |
| Dec 31, 2021 | -995.26% |
| Sep 30, 2021 | -161.62% |
| Jun 30, 2021 | -321.81% |
API Access
Spero Therapeutics FCF Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=fcf-margin&ticker=SPRO&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "fcf-margin", "ticker": "SPRO", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=fcf-margin&ticker=SPRO&period=max&api_key=YOUR_API_KEY");
const data = await res.json();