Lyra Therapeutics (LYRA) Return on Invested Capital (2023 - 2025)
Quarterly Return on Invested Capital rose 10.0% to 0.04% in Q4 2025 from the year-ago period, while the trailing twelve-month figure was 0.04% through Dec 2025, up 10.0% year-over-year, with the annual reading at 0.71% for FY2025, 69.0% down from the prior year.
Lyra Therapeutics' Return on Invested Capital history spans 3 years, with the latest figure at 0.04% for Q4 2025.
- Return on Invested Capital came in at 0.04% for Q4 2025, down from 0.26% in the prior quarter.
- In the past five years, Return on Invested Capital ranged from a high of 0.26% in Q3 2025 to a low of 0.15% in Q2 2025.
- The 3-year median for Return on Invested Capital is 0.02% (2024), against an average of 0.01%.
- The largest YoY upside for Return on Invested Capital was 30bps in 2025 against a maximum downside of -13bps in 2025.
- Lyra Therapeutics' Return on Invested Capital stood at 0.01% in 2023, then plummeted by -673bps to 0.06% in 2024, then surged by 169bps to 0.04% in 2025.
- Per Business Quant, the three most recent readings for LYRA's Return on Invested Capital are 0.04% (Q4 2025), 0.26% (Q3 2025), and 0.15% (Q2 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROIC (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,384,976.65 Bn | 1,384,976.64 Bn | - | - |
| 2 | Alterity Therapeutics | 777,208.84 Bn | 777,208.81 Bn | - | - |
| 3 | Legend Biotech | 2,801.00 Bn | 2,800.10 Bn | 242.10 Mn | - |
| 4 | Nanobiotix | 2,226.01 Bn | 2,225.95 Bn | - | - |
| 5 | Akari Therapeutics | 605.66 Bn | 605.66 Bn | - | -0.01% |
| 6 | Vertex Pharmaceuticals | 110.17 Bn | 102.92 Bn | 2.59 Bn | 0.00% |
| 7 | Regeneron Pharmaceuticals | 66.86 Bn | 58.11 Bn | 3.31 Bn | 0.00% |
| 8 | Evaxion A | 65.12 Bn | 65.10 Bn | - | -0.01% |
| 9 | Alnylam Pharmaceuticals | 39.94 Bn | 36.94 Bn | 959.66 Mn | 0.01% |
| 10 | Lyra Therapeutics | - | - | - | 0.04% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 0.04% |
| Sep 30, 2025 | 0.26% |
| Jun 30, 2025 | -0.15% |
| Mar 31, 2025 | -0.11% |
| Dec 31, 2024 | -0.06% |
| Sep 30, 2024 | -0.04% |
| Jun 30, 2024 | -0.02% |
| Mar 31, 2024 | -0.01% |
| Dec 31, 2023 | -0.01% |