Lyra Therapeutics (LYRA) Return on Capital Employed (2020 - 2025)
Quarterly Return on Capital Employed rose 5870.0% to 102.09% in Q4 2025 from the year-ago period, while the trailing twelve-month figure was 102.09% through Dec 2025, up 5870.0% year-over-year, with the annual reading at 74.38% for FY2025, 3052.0% up from the prior year.
Lyra Therapeutics' Return on Capital Employed history spans 6 years, with the latest figure at 102.09% for Q4 2025.
- Return on Capital Employed came in at 102.09% for Q4 2025, down from 91.34% in the prior quarter.
- In the past five years, Return on Capital Employed ranged from a high of 35.48% in Q1 2021 to a low of 163.79% in Q1 2025.
- The 5-year median for Return on Capital Employed is 69.26% (2021), against an average of 88.44%.
- Year-over-year, Return on Capital Employed tumbled -12824bps in 2022 and then skyrocketed 9342bps in 2023.
- Lyra Therapeutics' Return on Capital Employed stood at 101.27% in 2021, then soared by 45bps to 56.17% in 2022, then dropped by -7bps to 59.93% in 2023, then tumbled by -168bps to 160.79% in 2024, then surged by 37bps to 102.09% in 2025.
- Per Business Quant, the three most recent readings for LYRA's Return on Capital Employed are 102.09% (Q4 2025), 91.34% (Q3 2025), and 95.92% (Q2 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROCE (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,384,976.65 Bn | 1,384,976.64 Bn | - | 450.31% |
| 2 | Alterity Therapeutics | 777,208.84 Bn | 777,208.81 Bn | - | - |
| 3 | Legend Biotech | 2,801.00 Bn | 2,800.10 Bn | 242.10 Mn | 51.73% |
| 4 | Nanobiotix | 2,226.01 Bn | 2,225.95 Bn | - | - |
| 5 | Akari Therapeutics | 605.66 Bn | 605.66 Bn | - | -107.40% |
| 6 | Vertex Pharmaceuticals | 110.17 Bn | 102.92 Bn | 2.59 Bn | 21.10% |
| 7 | Regeneron Pharmaceuticals | 66.86 Bn | 58.11 Bn | 3.31 Bn | 10.19% |
| 8 | Evaxion A | 65.12 Bn | 65.10 Bn | - | - |
| 9 | Alnylam Pharmaceuticals | 39.94 Bn | 36.94 Bn | 959.66 Mn | 20.34% |
| 10 | Lyra Therapeutics | - | - | - | -102.09% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -102.09% |
| Sep 30, 2025 | -91.34% |
| Jun 30, 2025 | -95.92% |
| Mar 31, 2025 | -163.79% |
| Dec 31, 2024 | -160.79% |
| Sep 30, 2024 | -141.42% |
| Jun 30, 2024 | -107.11% |
| Mar 31, 2024 | -59.45% |
| Dec 31, 2023 | -59.93% |
| Sep 30, 2023 | -63.33% |
| Jun 30, 2023 | -66.69% |
| Mar 31, 2023 | -70.30% |
| Dec 31, 2022 | -56.17% |
| Sep 30, 2022 | -49.30% |
| Jun 30, 2022 | -65.37% |
| Mar 31, 2022 | -163.72% |
| Dec 31, 2021 | -101.27% |
| Sep 30, 2021 | -68.23% |
| Jun 30, 2021 | -47.02% |
| Mar 31, 2021 | -35.48% |
| Dec 31, 2020 | -28.04% |
| Sep 30, 2020 | -22.91% |
| Jun 30, 2020 | -27.72% |
| Mar 31, 2020 | -75.50% |