Lyra Therapeutics (LYRA) Operating Margin (2021 - 2025)
Lyra Therapeutics' Operating Margin came in at -101685.71% for Q4 2025, down 96227.34 percentage points from -5458.37% a year earlier and down 76737.71 percentage points from the prior quarter.
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Analysis
Lyra Therapeutics (LYRA) Operating Margin (2021 - 2025) Analysis & Trends
For FY2025, Lyra Therapeutics' Operating Margin was -7794.47%, down 1513.64 percentage points from FY2024.
- Operating Margin has declined in each of the last three years, though with a four-year change of +7509.04 percentage points (FY2021 to FY2025).
- Going back by year, Operating Margin was -6280.83% in FY2024 (-1972.75 pp), -4308.09% in FY2023 (-177.05 pp), -4131.03% in FY2022 (+11172.47 pp) and -15303.51% in FY2021.
- The Q4 2025 figure represents the lowest quarterly Operating Margin since Q4 2022.
- Year-over-year, Operating Margin increased in two of the last eight quarters, with an average year-over-year change of -14260.38 percentage points.
- The fastest year-over-year change in Operating Margin over five years came in Q4 2023 (a gain of 126487.11 percentage points), and the weakest in Q4 2022 (a drop of 132740.25 percentage points).
- Business Quant data shows LYRA's Operating Margin at -24948.00% (Q3 2025), -4822.95% (Q2 2025) and -4831.15% (Q1 2025) in the three quarters before Q4 2025.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 645.01 Bn | 563.54 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 465.23 Bn | 438.39 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 368.40 Bn | 322.83 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 278.02 Bn | 233.89 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 254.57 Bn | 228.13 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 229.02 Bn | 184.42 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 187.74 Bn | 161.85 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.45 Bn | 105.45 Bn | 2.84 Bn | 37.40% |
| 10 | Lyra Therapeutics | 354,976.41 | 354,976.41 | - | -101,685.71% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | -101,685.71% |
| Sep 30, 2025 | -24,948.00% |
| Jun 30, 2025 | -4,822.95% |
| Mar 31, 2025 | -4,831.15% |
| Dec 31, 2024 | -5,458.37% |
| Sep 30, 2024 | -6,380.51% |
| Jun 30, 2024 | -8,189.63% |
| Mar 31, 2024 | -4,421.80% |
| Dec 31, 2023 | -11,285.62% |
| Sep 30, 2023 | -3,093.20% |
| Jun 30, 2023 | -3,603.28% |
| Mar 31, 2023 | -4,222.68% |
| Dec 31, 2022 | -137,772.73% |
| Sep 30, 2022 | -4,129.81% |
| Jun 30, 2022 | -2,742.86% |
| Mar 31, 2022 | -2,548.08% |
| Dec 31, 2021 | -5,032.47% |
| Sep 30, 2021 | -79,150.00% |
API Access
Lyra Therapeutics Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=LYRA&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "LYRA", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=LYRA&period=max&api_key=YOUR_API_KEY");
const data = await res.json();