Lyra Therapeutics (LYRA) EPS (Weighted Average and Diluted) (2021 - 2025)
Quarterly EPS (Weighted Average and Diluted) rose 54.58% to -$3.77 in Q4 2025 from the year-ago period, while the trailing twelve-month figure was -$12.79 through Dec 2025, up 76.52% year-over-year, with the annual reading at -$18.62 for FY2025, 74.05% up from the prior year.
Lyra Therapeutics' EPS (Weighted Average and Diluted) history spans 5 years, with the latest figure at -$3.77 for Q4 2025.
- EPS (Weighted Average and Diluted) came in at -$3.77 for Q4 2025, down from -$3.38 in the prior quarter.
- In the past five years, EPS (Weighted Average and Diluted) ranged from a high of -$0.13 in Q1 2025 to a low of -$36.76 in Q2 2024.
- The 5-year median for EPS (Weighted Average and Diluted) is -$0.72 (2021), against an average of -$3.7.
- Year-over-year, EPS (Weighted Average and Diluted) tumbled 10111.11% in 2024 and then soared 85.01% in 2025.
- Lyra Therapeutics' EPS (Weighted Average and Diluted) stood at -$1.05 in 2021, then skyrocketed by 65.71% to -$0.36 in 2022, then surged by 38.89% to -$0.22 in 2023, then plummeted by 3672.73% to -$8.3 in 2024, then skyrocketed by 54.58% to -$3.77 in 2025.
- Per Business Quant, the three most recent readings for LYRA's EPS (Weighted Average and Diluted) are -$3.77 (Q4 2025), -$3.38 (Q3 2025), and -$5.51 (Q2 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EPS (Weighted Avg. Diluted) (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,384,976.65 Bn | 1,384,976.64 Bn | - | -4.43 |
| 2 | Alterity Therapeutics | 777,208.84 Bn | 777,208.81 Bn | - | - |
| 3 | Legend Biotech | 2,801.00 Bn | 2,800.10 Bn | 242.10 Mn | 3,086.42 |
| 4 | Nanobiotix | 2,226.01 Bn | 2,225.95 Bn | - | - |
| 5 | Akari Therapeutics | 605.66 Bn | 605.66 Bn | - | 0.00 |
| 6 | Vertex Pharmaceuticals | 110.17 Bn | 102.92 Bn | 2.59 Bn | 4.02 |
| 7 | Regeneron Pharmaceuticals | 66.86 Bn | 58.11 Bn | 3.31 Bn | 6.75 |
| 8 | Evaxion A | 65.12 Bn | 65.10 Bn | - | - |
| 9 | Alnylam Pharmaceuticals | 39.94 Bn | 36.94 Bn | 959.66 Mn | 1.51 |
| 10 | Lyra Therapeutics | - | - | - | -3.77 |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -3.77 |
| Sep 30, 2025 | -3.38 |
| Jun 30, 2025 | -5.51 |
| Mar 31, 2025 | -0.13 |
| Dec 31, 2024 | -8.30 |
| Sep 30, 2024 | -9.07 |
| Jun 30, 2024 | -36.76 |
| Mar 31, 2024 | -0.35 |
| Dec 31, 2023 | -0.22 |
| Sep 30, 2023 | -0.27 |
| Jun 30, 2023 | -0.36 |
| Mar 31, 2023 | -0.44 |
| Dec 31, 2022 | -0.36 |
| Sep 30, 2022 | -0.40 |
| Jun 30, 2022 | -0.42 |
| Mar 31, 2022 | -0.92 |
| Dec 31, 2021 | -1.05 |
| Sep 30, 2021 | -0.85 |
| Jun 30, 2021 | -0.85 |
| Mar 31, 2021 | -0.60 |