Lyra Therapeutics (LYRA) Research & Development (2019 - 2025)
Quarterly Research & Development fell 31.19% to $4.4 million in Q4 2025 from the year-ago period, while the trailing twelve-month figure was $18.4 million through Dec 2025, down 57.93% year-over-year, with the annual reading at $18.4 million for FY2025, 57.93% down from the prior year.
Lyra Therapeutics' Research & Development history spans 7 years, with the latest figure at $4.4 million for Q4 2025.
- Research & Development came in at $4.4 million for Q4 2025, up from $4.0 million in the prior quarter.
- In the past five years, Research & Development ranged from a high of $18.2 million in Q1 2024 to a low of $4.0 million in Q3 2025.
- The 5-year median for Research & Development is $9.0 million (2022), against an average of $8.9 million.
- Year-over-year, Research & Development soared 256.87% in 2021 and then plummeted 73.26% in 2025.
- Lyra Therapeutics' Research & Development stood at $10.3 million in 2021, then decreased by 8.62% to $9.5 million in 2022, then rose by 29.79% to $12.3 million in 2023, then plummeted by 48.13% to $6.4 million in 2024, then crashed by 31.19% to $4.4 million in 2025.
- Per Business Quant, the three most recent readings for LYRA's Research & Development are $4.4 million (Q4 2025), $4.0 million (Q3 2025), and $5.1 million (Q2 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | R&D (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,384,976.65 Bn | 1,384,976.64 Bn | - | 626,092.00 |
| 2 | Alterity Therapeutics | 777,208.84 Bn | 777,208.81 Bn | - | 4.32 Mn |
| 3 | Legend Biotech | 2,801.00 Bn | 2,800.10 Bn | 242.10 Mn | -101.30 Mn |
| 4 | Nanobiotix | 2,226.01 Bn | 2,225.95 Bn | - | - |
| 5 | Akari Therapeutics | 605.66 Bn | 605.66 Bn | - | 1.46 Mn |
| 6 | Vertex Pharmaceuticals | 110.17 Bn | 102.92 Bn | 2.59 Bn | 961.60 Mn |
| 7 | Regeneron Pharmaceuticals | 66.86 Bn | 58.11 Bn | 3.31 Bn | 1.54 Bn |
| 8 | Evaxion A | 65.12 Bn | 65.10 Bn | - | -2.30 Mn |
| 9 | Alnylam Pharmaceuticals | 39.94 Bn | 36.94 Bn | 959.66 Mn | 364.87 Mn |
| 10 | Lyra Therapeutics | - | - | - | 4.38 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 4.38 Mn |
| Sep 30, 2025 | 4.05 Mn |
| Jun 30, 2025 | 5.11 Mn |
| Mar 31, 2025 | 4.88 Mn |
| Dec 31, 2024 | 6.36 Mn |
| Sep 30, 2024 | 5.90 Mn |
| Jun 30, 2024 | 13.26 Mn |
| Mar 31, 2024 | 18.24 Mn |
| Dec 31, 2023 | 12.27 Mn |
| Sep 30, 2023 | 12.37 Mn |
| Jun 30, 2023 | 10.80 Mn |
| Mar 31, 2023 | 12.60 Mn |
| Dec 31, 2022 | 9.45 Mn |
| Sep 30, 2022 | 10.05 Mn |
| Jun 30, 2022 | 10.79 Mn |
| Mar 31, 2022 | 8.51 Mn |
| Dec 31, 2021 | 10.34 Mn |
| Sep 30, 2021 | 7.08 Mn |
| Jun 30, 2021 | 7.51 Mn |
| Mar 31, 2021 | 4.77 Mn |
| Dec 31, 2020 | 3.74 Mn |
| Sep 30, 2020 | 3.71 Mn |
| Jun 30, 2020 | 2.10 Mn |
| Mar 31, 2020 | 2.96 Mn |
| Dec 31, 2019 | 3.01 Mn |
| Sep 30, 2019 | 2.84 Mn |
| Jun 30, 2019 | 3.42 Mn |
| Mar 31, 2019 | 2.76 Mn |